Research Themes

The two principle research themes in the lab are the mechanisms of arterial and lymphatics formation and angiogenic growth factor signaling. These process are investigated at all levels, including in vitro signaling studies, in vivo mouse transgenic and knock-out models and translational studies in larger animal models and in early phase clinical trials.

Arteriogenesis studies are currently concentrating on interactions of FGF, VEGF, Notch/Delta and WNT signaling pathways. Growth factor signaling studies are exploring cross-talks between different signaling pathways and the role of receptor trafficking in regulation of tyrosine kinase receptors signaling.