2009
The Subendothelial Extracellular Matrix Modulates JNK Activation by Flow
Hahn C, Orr AW, Sanders JM, Jhaveri KA, Schwartz MA. The Subendothelial Extracellular Matrix Modulates JNK Activation by Flow. Circulation Research 2009, 104: 995-1003. PMID: 19286608, PMCID: PMC2702158, DOI: 10.1161/circresaha.108.186486.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApolipoproteins EAtherosclerosisBasement MembraneCattleCell Culture TechniquesCells, CulturedCollagenDisease Models, AnimalEndothelial CellsEnzyme ActivationExtracellular MatrixFibronectinsHemorheologyInflammationIntegrinsJNK Mitogen-Activated Protein KinasesMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase KinasesOscillometryP21-Activated KinasesPhosphorylationRegional Blood FlowStress, Mechanical
2003
Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl
Truong T, Sun G, Doorly M, Wang JY, Schwartz MA. Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 10281-10286. PMID: 12928501, PMCID: PMC193552, DOI: 10.1073/pnas.1635435100.Peer-Reviewed Original ResearchConceptsC-Abl/p73 pathwayDNA damageIntegrin ligationC-AblDNA damage-induced apoptosisC-Abl tyrosine kinaseCell adhesionExtracellular matrixDamage-induced apoptosisP73 pathwayCertain cell typesP53-negative tumor cellsProapoptotic transcription factorTranscription factorsTyrosine kinaseApoptotic responseDifferential utilizationCell typesDifferent tumor cell linesTumor cell linesTumor cellsP53 levelsCell linesSecond pathwayCell killing
1997
Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo.
Brooks P, Klemke R, Schon S, Lewis J, Schwartz M, Cheresh D. Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo. Journal Of Clinical Investigation 1997, 99: 1390-1398. PMID: 9077549, PMCID: PMC507955, DOI: 10.1172/jci119298.Peer-Reviewed Original ResearchConceptsAlpha v beta 5Integrin alpha v beta 5Beta 5Growth factor-mediated signalsInsulin-like growth factor receptorSpontaneous pulmonary metastasesTumor cell metastasisMultiple tumor cell typesGrowth factor receptorIntegrin ligationCell motilityAdhesion proteinsTumor cell interactionsFunctional cooperationTumor cell growthCytokine receptorsTumor cell typesPulmonary metastasesCell typesCell metastasisCell growthMultiple tumor typesMetastatic cascadeTumor cellsFactor receptor