Publications

• Parametric FDG PET K(i) images using dual-time-point imaging data for cardiac sarcoidosis: a proof of concept study.Wu J, Young BD, Liu H, Sadeghi MM, Miller EJ, Liu C. J Nucl Cardiol. 2024 Dec 7; 2024 Dec 7. PMID: 39653168.
• Psychological stress and vessel wall inflammation: Opportunity of reducing cardiovascular risk in people with HIV.Chan P, Sadeghi MM. Brain Behav Immun. 2024 Jan; 2023 Oct 10. PMID: 37820976.
• Advancing the mission of cardiovascular molecular imaging.Dorbala S, Zhou W, Sadeghi M. J Nucl Cardiol. 2023 Dec; 2021 Mar 2. PMID: 33655449.
• ACR Appropriateness Criteria® Pulsatile Abdominal Mass, Suspected Abdominal Aortic Aneurysm: 2023 Update.Wang DS, Shen J, Majdalany BS, Khaja MS, Bhatti S, Ferencik M, Ganguli S, Gunn AJ, Heitner JF, Johri AM, Obara P, Ohle R, Sadeghi MM, Schermerhorn M, Siracuse JJ, Steenburg SD, Sutphin PD, Vijay K, Waite K, Steigner ML. J Am Coll Radiol. 2023 Nov. PMID: 38040468.
• Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve.Ahmad AA, Ghim M, Toczek J, Neishabouri A, Ojha D, Zhang Z, Gona K, Raza MZ, Jung JJ, Kukreja G, Zhang J, Guerrera N, Liu C, Sadeghi MM. J Nucl Med. 2023 Sep; 2023 Jun 15. PMID: 37321825.
• Characteristics and 1-year outcomes of patients with rupture of small abdominal aortic aneurysms.Bellamkonda KS, Zogg C, Nassiri N, Sadeghi MM, Zhang Y, Guzman RJ, Ochoa Chaar CI. J Vasc Surg. 2023 Jun; 2023 Feb 14. PMID: 36796595.
• Homeostatic, Non-Canonical Role of Macrophage Elastase in Vascular Integrity.Salarian M, Ghim M, Toczek J, Han J, Weiss D, Spronck B, Ramachandra AB, Jung JJ, Kukreja G, Zhang J, Lakheram D, Kim SK, Humphrey JD, Sadeghi MM. Circ Res. 2023 Feb 17; 2023 Jan 24. PMID: 36691905.
• Positron Emission Tomography Imaging of Vessel Wall Matrix Metalloproteinase Activity in Abdominal Aortic Aneurysm.Toczek J, Gona K, Liu Y, Ahmad A, Ghim M, Ojha D, Kukreja G, Salarian M, Luehmann H, Heo GS, Guzman RJ, Ochoa Chaar CI, Tellides G, Hassab AHM, Ye Y, Shoghi KI, Zayed MA, Gropler RJ, Sadeghi MM. Circ Cardiovasc Imaging. 2023 Jan; 2023 Jan 17. PMID: 36649454.
• Beyond perfusion imaging.Sadeghi MM. J Nucl Cardiol. 2022 Aug; 2022 Jul 5. PMID: 35790690.
• Deletion of matrix metalloproteinase-12 compromises mechanical homeostasis and leads to an aged aortic phenotype in young mice.Spronck B, Ramachandra AB, Moriyama L, Toczek J, Han J, Sadeghi MM, Humphrey JD. J Biomech. 2022 Aug; 2022 Jun 10. PMID: 35759974.
• Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 2: Inflammation, Fibrosis, Thrombosis, Calcification, and Amyloidosis Imaging.Stendahl JC, Kwan JM, Pucar D, Sadeghi MM. J Nucl Med. 2022 Jul. PMID: 35772956.
• Targeted Suppression of miRNA-33 Using pHLIP Improves Atherosclerosis Regression.Zhang X, Rotllan N, Canfrán-Duque A, Sun J, Toczek J, Moshnikova A, Malik S, Price NL, Araldi E, Zhong W, Sadeghi MM, Andreev OA, Bahal R, Reshetnyak YK, Suárez Y, Fernández-Hernando C. Circ Res. 2022 Jun 24; 2022 May 9. PMID: 35534923.
• Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 1: Technical Considerations and Perfusion and Neuronal Imaging.Stendahl JC, Kwan JM, Pucar D, Sadeghi MM. J Nucl Med. 2022 May. PMID: 35487563.
• Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification.Jung JJ, Ahmad AA, Rajendran S, Wei L, Zhang J, Toczek J, Nie L, Kukreja G, Salarian M, Gona K, Ghim M, Chakraborty R, Martin KA, Tellides G, Heistad D, Sadeghi MM. JACC Basic Transl Sci. 2022 Apr; 2022 Mar 23. PMID: 35540096.
• Characteristics and outcomes of small abdominal aortic aneurysm rupture in the American College of Surgeons National Surgical Quality Improvement Program database.Bellamkonda KS, Nassiri N, Sadeghi MM, Zhang Y, Guzman RJ, Ochoa Chaar CI. J Vasc Surg. 2021 Sep; 2021 Feb 19. PMID: 33617982.
• ESDN inhibits melanoma progression by blocking E-selectin expression in endothelial cells via STAT3.Coppo R, Orso F, Virga F, Dalmasso A, Baruffaldi D, Nie L, Clapero F, Dettori D, Quirico L, Grassi E, Defilippi P, Provero P, Valdembri D, Serini G, Sadeghi MM, Mazzone M, Taverna D. Cancer Lett. 2021 Jul 10; 2021 Apr 13. PMID: 33862151.
• (18)F-Fluorodeoxyglucose PET imaging in aortic graft infection: many more questions than answers.Pucar D, Sadeghi MM. J Nucl Cardiol. 2021 Jun; 2020 Jun 30. PMID: 32607838.
• Computed tomography imaging of macrophage phagocytic activity in abdominal aortic aneurysm.Toczek J, Boodagh P, Sanzida N, Ghim M, Salarian M, Gona K, Kukreja G, Rajendran S, Wei L, Han J, Zhang J, Jung JJ, Graham M, Liu X, Sadeghi MM. Theranostics. 2021; 2021 Apr 3. PMID: 33897887.
• FDG PET imaging of vascular inflammation in post-traumatic stress disorder: A pilot case-control study.Toczek J, Hillmer AT, Han J, Liu C, Peters D, Emami H, Wu J, Esterlis I, Cosgrove KP, Sadeghi MM. J Nucl Cardiol. 2021 Apr; 2019 May 9. PMID: 31073848.
• Hydroxamate-Based Selective Macrophage Elastase (MMP-12) Inhibitors and Radiotracers for Molecular Imaging.Gona K, Toczek J, Ye Y, Sanzida N, Golbazi A, Boodagh P, Salarian M, Jung JJ, Rajendran S, Kukreja G, Wu TL, Devel L, Sadeghi MM. J Med Chem. 2020 Dec 10; 2020 Nov 18. PMID: 33206510.
• 2020 SNMMI Highlights Lecture: Cardiovascular Nuclear and Molecular Imaging.Sadeghi MM. J Nucl Med. 2020 Nov. PMID: 33139397.
• Accuracy of arterial [(18)F]-Fluorodeoxyglucose uptake quantification: A kinetic modeling study.Toczek J, Wu J, Hillmer AT, Han J, Esterlis I, Cosgrove KP, Liu C, Sadeghi MM. J Nucl Cardiol. 2020 Oct; 2020 Feb 10. PMID: 32043239.
• Reply to letter to the editor regarding "prevalence and variability in reporting of clinically actionable incidental findings on attenuation-correction CT scans in a veteran population".Malm BJ, He BJ, Carino M, Sadeghi MM. J Nucl Cardiol. 2020 Jun; 2019 Mar 1. PMID: 30825113.
• 2019 SNMMI Highlights Lecture: Cardiovascular Nuclear and Molecular Imaging.Sadeghi MM. J Nucl Med. 2019 Dec. PMID: 31792135.
• Genetic deficiency or pharmacological inhibition of miR-33 protects from kidney fibrosis.Price NL, Miguel V, Ding W, Singh AK, Malik S, Rotllan N, Moshnikova A, Toczek J, Zeiss C, Sadeghi MM, Arias N, Baldán Á, Andreev OA, Rodríguez-Puyol D, Bahal R, Reshetnyak YK, Suárez Y, Fernández-Hernando C, Lamas S. JCI Insight. 2019 Nov 14; 2019 Nov 14. PMID: 31613798.
• Novel Matrix Metalloproteinase 12 Selective Radiotracers for Vascular Molecular Imaging.Toczek J, Bordenave T, Gona K, Kim HY, Beau F, Georgiadis D, Correia I, Ye Y, Razavian M, Jung JJ, Lequin O, Dive V, Sadeghi MM, Devel L. J Med Chem. 2019 Nov 14; 2019 Oct 25. PMID: 31603669.
• Prevalence and variability in reporting of clinically actionable incidental findings on attenuation-correction CT scans in a veteran population.He BJ, Malm BJ, Carino M, Sadeghi MM. J Nucl Cardiol. 2019 Oct; 2018 Feb 28. PMID: 29492838.
• Hype or Hope((18)F-NaF Positron Emission Tomography for Vulnerable Coronary Plaque Imaging).Salarian M, Sadeghi MM. Circ Cardiovasc Imaging. 2019 Aug; 2019 Aug 6. PMID: 31382767.
• PET-Based Imaging of Ischemic Heart Disease.Chen K, Miller EJ, Sadeghi MM. PET Clin. 2019 Apr; 2019 Feb 1. PMID: 30826019.
• (18)F-Sodium Fluoride Positron Emission Tomography and Plaque Calcification.Tavakoli S, Sadeghi MM. Circ Cardiovasc Imaging. 2019 Jan. PMID: 30642218.
• 2018 SNMMI Highlights Lecture: Cardiovascular Nuclear and Molecular Imaging.Sadeghi MM. J Nucl Med. 2018 Sep. PMID: 30181235.
• Novel Arginine-containing Macrocyclic MMP Inhibitors: Synthesis, (99m)Tc-labeling, and Evaluation.Ye Y, Toczek J, Gona K, Kim HY, Han J, Razavian M, Golestani R, Zhang J, Wu TL, Ghosh M, Jung JJ, Sadeghi MM. Sci Rep. 2018 Aug 3; 2018 Aug 3. PMID: 30076321.
• Molecular imaging of calcific aortic valve disease.Jung JJ, Jadbabaie F, Sadeghi MM. J Nucl Cardiol. 2018 Aug; 2018 Jan 22. PMID: 29359271.
• Myocardial perfusion imaging: Lessons learned and work to be done-update.Iskandrian AE, Dilsizian V, Garcia EV, Beanlands RS, Cerqueira M, Soman P, Berman DS, Cuocolo A, Einstein AJ, Morgan CJ, Hage FG, Schelbert HR, Bax JJ, Wu JC, Shaw LJ, Sadeghi MM, Tamaki N, Kaufmann PA, Gropler R, Dorbala S, Van Decker W. J Nucl Cardiol. 2018 Feb; 2017 Nov 6. PMID: 29110288.
• Characterization of Macrophage Polarization States Using Combined Measurement of 2-Deoxyglucose and Glutamine Accumulation: Implications for Imaging of Atherosclerosis.Tavakoli S, Downs K, Short JD, Nguyen HN, Lai Y, Jerabek PA, Goins B, Toczek J, Sadeghi MM, Asmis R. Arterioscler Thromb Vasc Biol. 2017 Oct; 2017 Aug 10. PMID: 28798141.
• Multi-modality molecular imaging of aortic aneurysms.Malm BJ, Sadeghi MM. J Nucl Cardiol. 2017 Aug; 2017 Apr 26. PMID: 28447279.
• Preclinical Evaluation of RYM1, a Matrix Metalloproteinase-Targeted Tracer for Imaging Aneurysm.Toczek J, Ye Y, Gona K, Kim HY, Han J, Razavian M, Golestani R, Zhang J, Wu TL, Jung JJ, Sadeghi MM. J Nucl Med. 2017 Aug; 2017 Mar 30. PMID: 28360209.
• Differential Regulation of Macrophage Glucose Metabolism by Macrophage Colony-stimulating Factor and Granulocyte-Macrophage Colony-stimulating Factor: Implications for (18)F FDG PET Imaging of Vessel Wall Inflammation.Tavakoli S, Short JD, Downs K, Nguyen HN, Lai Y, Zhang W, Jerabek P, Goins B, Sadeghi MM, Asmis R. Radiology. 2017 Apr; 2016 Nov 16. PMID: 27849433.
• Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1β Production.Ceneri N, Zhao L, Young BD, Healy A, Coskun S, Vasavada H, Yarovinsky TO, Ike K, Pardi R, Qin L, Qin L, Tellides G, Hirschi K, Meadows J, Soufer R, Chun HJ, Sadeghi MM, Bender JR, Morrison AR. Arterioscler Thromb Vasc Biol. 2017 Feb; 2016 Nov 10. PMID: 27834690.
• Matrix Metalloproteinase-Targeted Imaging of Lung Inflammation and Remodeling.Golestani R, Razavian M, Ye Y, Zhang J, Jung JJ, Toczek J, Gona K, Kim HY, Elias JA, Lee CG, Homer RJ, Sadeghi MM. J Nucl Med. 2017 Jan; 2016 Jul 28. PMID: 27469361.
• Optical imaging of MMP-12 active form in inflammation and aneurysm.Razavian M, Bordenave T, Georgiadis D, Beau F, Zhang J, Golestani R, Toczek J, Jung JJ, Ye Y, Kim HY, Han J, Dive V, Devel L, Sadeghi MM. Sci Rep. 2016 Dec 5; 2016 Dec 5. PMID: 27917892.
• Synthesis and in Vitro and in Vivo Evaluation of MMP-12 Selective Optical Probes.Bordenave T, Helle M, Beau F, Georgiadis D, Tepshi L, Bernes M, Ye Y, Levenez L, Poquet E, Nozach H, Razavian M, Toczek J, Stura EA, Dive V, Sadeghi MM, Devel L. Bioconjug Chem. 2016 Oct 19; 2016 Sep 14. PMID: 27564088.
• Matrix metalloproteinase inhibitor, doxycycline and progression of calcific aortic valve disease in hyperlipidemic mice.Jung JJ, Razavian M, Kim HY, Ye Y, Golestani R, Toczek J, Zhang J, Sadeghi MM. Sci Rep. 2016 Sep 13; 2016 Sep 13. PMID: 27619752.
• Molecular Imaging of Angiogenesis and Vascular Remodeling in Cardiovascular Pathology.Golestani R, Jung JJ, Sadeghi MM. J Clin Med. 2016 Jun 6; 2016 Jun 6. PMID: 27275836.
• A New Tracer for Imaging Atherosclerosis.Toczek J, Sadeghi MM. Circ Cardiovasc Imaging. 2016 May. PMID: 27162132.
• The neuropilin-like protein ESDN regulates insulin signaling and sensitivity.Li X, Jung JJ, Nie L, Razavian M, Zhang J, Samuel V, Sadeghi MM. Am J Physiol Heart Circ Physiol. 2016 May 1; 2016 Feb 26. PMID: 26921437.
• Molecular imaging concepts.Toczek J, Sadeghi MM. J Nucl Cardiol. 2016 Apr; 2016 Jan 25. PMID: 26809440.
• Molecular cardiovascular imaging is ready for prime time: almost there.Sadeghi MM. J Nucl Cardiol. 2016 Feb; 2015 Nov 5. PMID: 26542993.
• Novel Molecular Imaging Approaches to Abdominal Aortic Aneurysm Risk Stratification.Toczek J, Meadows JL, Sadeghi MM. Circ Cardiovasc Imaging. 2016 Jan. PMID: 26763279.
• Interferon-γ-mediated allograft rejection exacerbates cardiovascular disease of hyperlipidemic murine transplant recipients.Zhou J, Qin L, Yi T, Ali R, Li Q, Jiao Y, Li G, Tobiasova Z, Huang Y, Zhang J, Yun JJ, Sadeghi MM, Giordano FJ, Pober JS, Tellides G. Circ Res. 2015 Nov 6; 2015 Sep 23. PMID: 26399469.
• Multimodality and molecular imaging of matrix metalloproteinase activation in calcific aortic valve disease.Jung JJ, Razavian M, Challa AA, Nie L, Golestani R, Zhang J, Ye Y, Russell KS, Robinson SP, Heistad DD, Sadeghi MM. J Nucl Med. 2015 Jun; 2015 Apr 23. PMID: 25908827.
• Cardiovascular molecular imaging: Expanding the paradigms and parameters.Sadeghi MM, Wu JC. J Nucl Cardiol. 2015 Jun; 2015 Mar 26. PMID: 25809082.
• (18)F-FDG PET and vascular inflammation: time to refine the paradigm?Sadeghi MM. J Nucl Cardiol. 2015 Apr. PMID: 24925623.
• Imaging vessel wall biology to predict outcome in abdominal aortic aneurysm.Golestani R, Razavian M, Nie L, Zhang J, Jung JJ, Ye Y, de Roo M, Hilgerink K, Liu C, Robinson SP, Sadeghi MM. Circ Cardiovasc Imaging. 2015 Jan; 2014 Dec 30. PMID: 25550400.
• Calcific aortic valve disease: a consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease.Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM, Hofmann-Bowman MA, Mortlock DP, Rogers MB, Sadeghi MM, Aikawa E. Arterioscler Thromb Vasc Biol. 2014 Nov; 2014 Sep 4. PMID: 25189570.
• Emergence of molecular imaging of aortic aneurysm: implications for risk stratification and management.Golestani R, Sadeghi MM. J Nucl Cardiol. 2014 Apr; 2014 Jan 1. PMID: 24381115.
• Lipid lowering and imaging protease activation in atherosclerosis.Razavian M, Nie L, Challa A, Zhang J, Golestani R, Jung JJ, Robinson S, Sadeghi MM. J Nucl Cardiol. 2014 Apr; 2013 Dec 25. PMID: 24368425.
• Molecular imaging of vascular endothelial growth factor receptors in graft arteriosclerosis.Zhang J, Razavian M, Tavakoli S, Nie L, Tellides G, Backer JM, Backer MV, Bender JR, Sadeghi MM. Arterioscler Thromb Vasc Biol. 2012 Aug; 2012 Jun 21. PMID: 22723442.
• Integrin-targeted imaging of inflammation in vascular remodeling.Razavian M, Marfatia R, Mongue-Din H, Tavakoli S, Sinusas AJ, Zhang J, Nie L, Sadeghi MM. Arterioscler Thromb Vasc Biol. 2011 Dec; 2011 Sep 22. PMID: 21940943.
• Atherosclerosis plaque heterogeneity and response to therapy detected by in vivo molecular imaging of matrix metalloproteinase activation.Razavian M, Tavakoli S, Zhang J, Nie L, Dobrucki LW, Sinusas AJ, Azure M, Robinson S, Sadeghi MM. J Nucl Med. 2011 Nov; 2011 Oct 3. PMID: 21969358.
• VEGF blockade inhibits lymphocyte recruitment and ameliorates immune-mediated vascular remodeling.Zhang J, Silva T, Yarovinsky T, Manes TD, Tavakoli S, Nie L, Tellides G, Pober JS, Bender JR, Sadeghi MM. Circ Res. 2010 Aug 6; 2010 Jun 10. PMID: 20538685.
• Molecular imaging of matrix metalloproteinase activation to predict murine aneurysm expansion in vivo.Razavian M, Zhang J, Nie L, Tavakoli S, Razavian N, Dobrucki LW, Sinusas AJ, Edwards DS, Azure M, Sadeghi MM. J Nucl Med. 2010 Jul; 2010 Jun 16. PMID: 20554725.
• Imaging atherosclerosis and vulnerable plaque.Sadeghi MM, Glover DK, Lanza GM, Fayad ZA, Johnson LL. J Nucl Med. 2010 May 1; 2010 Apr 15. PMID: 20395341.
• Endothelial and smooth muscle-derived neuropilin-like protein regulates platelet-derived growth factor signaling in human vascular smooth muscle cells by modulating receptor ubiquitination.Guo X, Nie L, Esmailzadeh L, Zhang J, Bender JR, Sadeghi MM. J Biol Chem. 2009 Oct 23; 2009 Aug 19. PMID: 19696027.
• Molecular imaging of activated matrix metalloproteinases in vascular remodeling.Zhang J, Nie L, Razavian M, Ahmed M, Dobrucki LW, Asadi A, Edwards DS, Azure M, Sinusas AJ, Sadeghi MM. Circulation. 2008 Nov 4; 2008 Oct 20. PMID: 18936327.
• Targeted imaging of hypoxia-induced integrin activation in myocardium early after infarction.Kalinowski L, Dobrucki LW, Meoli DF, Dione DP, Sadeghi MM, Madri JA, Sinusas AJ. J Appl Physiol (1985). 2008 May; 2008 Mar 20. PMID: 18356482.
• Activated alphavbeta3 integrin targeting in injury-induced vascular remodeling.Sadeghi MM, Bender JR. Trends Cardiovasc Med. 2007 Jan. PMID: 17210471.
• The pathobiology of the vessel wall: implications for imaging.Sadeghi MM. J Nucl Cardiol. 2006 May-Jun. PMID: 16750785.
• Alphavbeta3-targeted detection of arteriopathy in transplanted human coronary arteries: an autoradiographic study.Zhang J, Krassilnikova S, Gharaei AA, Fassaei HR, Esmailzadeh L, Asadi A, Edwards DS, Harris TD, Azure M, Tellides G, Sinusas AJ, Zaret BL, Bender JR, Sadeghi MM. FASEB J. 2005 Nov; 2005 Sep 8. PMID: 16150802.
• Noninvasive imaging of angiogenesis with a 99mTc-labeled peptide targeted at alphavbeta3 integrin after murine hindlimb ischemia.Hua J, Dobrucki LW, Sadeghi MM, Zhang J, Bourke BN, Cavaliere P, Song J, Chow C, Jahanshad N, van Royen N, Buschmann I, Madri JA, Mendizabal M, Sinusas AJ. Circulation. 2005 Jun 21; 2005 Jun 13. PMID: 15956134.
• Detection of injury-induced vascular remodeling by targeting activated alphavbeta3 integrin in vivo.Sadeghi MM, Krassilnikova S, Zhang J, Gharaei AA, Fassaei HR, Esmailzadeh L, Kooshkabadi A, Edwards S, Yalamanchili P, Harris TD, Sinusas AJ, Zaret BL, Bender JR. Circulation. 2004 Jul 6; 2004 Jun 21. PMID: 15210600.
• Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction.Meoli DF, Sadeghi MM, Krassilnikova S, Bourke BN, Giordano FJ, Dione DP, Su H, Edwards DS, Liu S, Harris TD, Madri JA, Zaret BL, Sinusas AJ. J Clin Invest. 2004 Jun. PMID: 15199403.