Publications

• Identification of the potassium-binding site in serotonin transporter.Hellsberg E, Boytsov D, Chen Q, Niello M, Freissmuth M, Rudnick G, Zhang YW, Sandtner W, Forrest LR. Proc Natl Acad Sci U S A. 2024 Apr 30; 2024 Apr 23. PMID: 38652746.
• Ionized gas extends over 40 kpc in an odd radio circle host galaxy.Coil AL, Perrotta S, Rupke DSN, Lochhaas C, Tremonti CA, Diamond-Stanic A, Fielding D, Geach JE, Hickox RC, Moustakas J, Rudnick GH, Sell P, Whalen KE. Nature. 2024 Jan; 2024 Jan 8. PMID: 38191936.
• Mephedrone induces partial release at human dopamine transporters but full release at human serotonin transporters.Mayer FP, Niello M, Bulling S, Zhang YW, Li Y, Kudlacek O, Holy M, Kooti F, Sandtner W, Rudnick G, Schmid D, Sitte HH. Neuropharmacology. 2023 Dec 1; 2023 Sep 11. PMID: 37703919.
• Structure-based discovery of conformationally selective inhibitors of the serotonin transporter.Singh I, Seth A, Billesbølle CB, Braz J, Rodriguiz RM, Roy K, Bekele B, Craik V, Huang XP, Boytsov D, Pogorelov VM, Lak P, O'Donnell H, Sandtner W, Irwin JJ, Roth BL, Basbaum AI, Wetsel WC, Manglik A, Shoichet BK, Rudnick G. Cell. 2023 May 11; 2023 May 2. PMID: 37137306.
• Forty Four Years With Baruch Kanner and The Chloride Ion.Rudnick G. Neurochem Res. 2022 Jan; 2021 Apr 30. PMID: 33929682.
• Chloride-dependent conformational changes in the GlyT1 glycine transporter.Zhang YW, Uchendu S, Leone V, Bradshaw RT, Sangwa N, Forrest LR, Rudnick G. Proc Natl Acad Sci U S A. 2021 Mar 9. PMID: 33658361.
• Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning.Unger EK, Keller JP, Altermatt M, Liang R, Matsui A, Dong C, Hon OJ, Yao Z, Sun J, Banala S, Flanigan ME, Jaffe DA, Hartanto S, Carlen J, Mizuno GO, Borden PM, Shivange AV, Cameron LP, Sinning S, Underhill SM, Olson DE, Amara SG, Temple Lang D, Rudnick G, Marvin JS, Lavis LD, Lester HA, Alvarez VA, Fisher AJ, Prescher JA, Kash TL, Yarov-Yarovoy V, Gradinaru V, Looger LL, Tian L. Cell. 2020 Dec 23; 2020 Dec 16. PMID: 33333022.
• Unconventional transport of metal ions and protons by Nramps.Rudnick G. J Gen Physiol. 2019 Dec 2; 2019 Nov 5. PMID: 31690583.
• Serotonin transport in the 21st century.Rudnick G, Sandtner W. J Gen Physiol. 2019 Nov 4; 2019 Sep 30. PMID: 31570504.
• A 100-kiloparsec wind feeding the circumgalactic medium of a massive compact galaxy.Rupke DSN, Coil A, Geach JE, Tremonti C, Diamond-Stanic AM, George ER, Hickox RC, Kepley AA, Leung G, Moustakas J, Rudnick G, Sell PH. Nature. 2019 Oct; 2019 Oct 30. PMID: 31666723.
• Structural elements required for coupling ion and substrate transport in the neurotransmitter transporter homolog LeuT.Zhang YW, Tavoulari S, Sinning S, Aleksandrova AA, Forrest LR, Rudnick G. Proc Natl Acad Sci U S A. 2018 Sep 18; 2018 Sep 4. PMID: 30181291.
• Control of serotonin transporter phosphorylation by conformational state.Zhang YW, Turk BE, Rudnick G. Proc Natl Acad Sci U S A. 2016 May 17; 2016 May 2. PMID: 27140629.
• Two Na+ Sites Control Conformational Change in a Neurotransmitter Transporter Homolog.Tavoulari S, Margheritis E, Nagarajan A, DeWitt DC, Zhang YW, Rosado E, Ravera S, Rhoades E, Forrest LR, Rudnick G. J Biol Chem. 2016 Jan 15; 2015 Nov 18. PMID: 26582198.
• Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine Transporters.Sandtner W, Stockner T, Hasenhuetl PS, Partilla JS, Seddik A, Zhang YW, Cao J, Holy M, Steinkellner T, Rudnick G, Baumann MH, Ecker GF, Newman AH, Sitte HH. Mol Pharmacol. 2016 Jan; 2015 Oct 30. PMID: 26519222.
• Stellar feedback as the origin of an extended molecular outflow in a starburst galaxy.Geach JE, Hickox RC, Diamond-Stanic AM, Krips M, Rudnick GH, Tremonti CA, Sell PH, Coil AL, Moustakas J. Nature. 2014 Dec 4. PMID: 25471881.
• Structure and regulatory interactions of the cytoplasmic terminal domains of serotonin transporter.Fenollar-Ferrer C, Stockner T, Schwarz TC, Pal A, Gotovina J, Hofmaier T, Jayaraman K, Adhikary S, Kudlacek O, Mehdipour AR, Tavoulari S, Rudnick G, Singh SK, Konrat R, Sitte HH, Forrest LR. Biochemistry. 2014 Aug 26; 2014 Aug 15. PMID: 25093911.
• The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction.Rudnick G, Krämer R, Blakely RD, Murphy DL, Verrey F. Pflugers Arch. 2014 Jan; 2013 Dec 13. PMID: 24337881.
• The Concise Guide to PHARMACOLOGY 2013/14: overview.Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M. Br J Pharmacol. 2013 Dec. PMID: 24528237.
• How do transporters couple solute movements?Rudnick G. Mol Membr Biol. 2013 Nov. PMID: 24147977.
• Isoforms of the neuronal glutamate transporter gene, SLC1A1/EAAC1, negatively modulate glutamate uptake: relevance to obsessive-compulsive disorder.Porton B, Greenberg BD, Askland K, Serra LM, Gesmonde J, Rudnick G, Rasmussen SA, Kao HT. Transl Psychiatry. 2013 May 21; 2013 May 21. PMID: 23695234.
• Cyclic GMP-dependent stimulation of serotonin transport does not involve direct transporter phosphorylation by cGMP-dependent protein kinase.Wong A, Zhang YW, Jeschke GR, Turk BE, Rudnick G. J Biol Chem. 2012 Oct 19; 2012 Aug 31. PMID: 22942288.
• The mechanistic basis for noncompetitive ibogaine inhibition of serotonin and dopamine transporters.Bulling S, Schicker K, Zhang YW, Steinkellner T, Stockner T, Gruber CW, Boehm S, Freissmuth M, Rudnick G, Sitte HH, Sandtner W. J Biol Chem. 2012 May 25; 2012 Mar 26. PMID: 22451652.
• Unifying concept of serotonin transporter-associated currents.Schicker K, Uzelac Z, Gesmonde J, Bulling S, Stockner T, Freissmuth M, Boehm S, Rudnick G, Sitte HH, Sandtner W. J Biol Chem. 2012 Jan 2; 2011 Nov 9. PMID: 22072712.
• Cytoplasmic permeation pathway of neurotransmitter transporters.Rudnick G. Biochemistry. 2011 Sep 6; 2011 Aug 10. PMID: 21774491.
• A conserved asparagine residue in transmembrane segment 1 (TM1) of serotonin transporter dictates chloride-coupled neurotransmitter transport.Henry LK, Iwamoto H, Field JR, Kaufmann K, Dawson ES, Jacobs MT, Adams C, Felts B, Zdravkovic I, Armstrong V, Combs S, Solis E Jr, Rudnick G, Noskov SY, DeFelice LJ, Meiler J, Blakely RD. J Biol Chem. 2011 Sep 2; 2011 Jul 5. PMID: 21730057.
• Reconstructing a chloride-binding site in a bacterial neurotransmitter transporter homologue.Tavoulari S, Rizwan AN, Forrest LR, Rudnick G. J Biol Chem. 2011 Jan 28; 2010 Nov 29. PMID: 21115480.
• Myristoylation of cGMP-dependent protein kinase dictates isoform specificity for serotonin transporter regulation.Zhang YW, Rudnick G. J Biol Chem. 2011 Jan 28; 2010 Nov 19. PMID: 21097501.
• Ligand effects on cross-linking support a conformational mechanism for serotonin transport.Tao Z, Zhang YW, Agyiri A, Rudnick G. J Biol Chem. 2009 Dec 4; 2009 Oct 16. PMID: 19837674.
• The rocking bundle: a mechanism for ion-coupled solute flux by symmetrical transporters.Forrest LR, Rudnick G. Physiology (Bethesda). 2009 Dec. PMID: 19996368.
• Fluoxetine (Prozac) binding to serotonin transporter is modulated by chloride and conformational changes.Tavoulari S, Forrest LR, Rudnick G. J Neurosci. 2009 Jul 29. PMID: 19641126.
• Mechanism for alternating access in neurotransmitter transporters.Forrest LR, Zhang YW, Jacobs MT, Gesmonde J, Xie L, Honig BH, Rudnick G. Proc Natl Acad Sci U S A. 2008 Jul 29; 2008 Jul 22. PMID: 18647834.
• Vesicular ATP transport is a hard (V)NUT to crack.Rudnick G. Proc Natl Acad Sci U S A. 2008 Apr 22; 2008 Apr 15. PMID: 18417450.
• Involvement of serotonin transporter extracellular loop 1 in serotonin binding and transport.Mao Y, Mathewson L, Gesmonde J, Sato Y, Holy M, Sitte HH, Rudnick G. Mol Membr Biol. 2008 Feb. PMID: 18307099.
• SERT Ileu425Val in autism, Asperger syndrome and obsessive-compulsive disorder.Wendland JR, DeGuzman TB, McMahon F, Rudnick G, Detera-Wadleigh SD, Murphy DL. Psychiatr Genet. 2008 Feb. PMID: 18197083.
• Ibogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter.Jacobs MT, Zhang YW, Campbell SD, Rudnick G. J Biol Chem. 2007 Oct 5; 2007 Aug 13. PMID: 17698848.
• Serotonin transporter phosphorylation by cGMP-dependent protein kinase is altered by a mutation associated with obsessive compulsive disorder.Zhang YW, Gesmonde J, Ramamoorthy S, Rudnick G. J Neurosci. 2007 Oct 3. PMID: 17913921.
• Interaction between lysine 102 and aspartate 338 in the insect amino acid cotransporter KAAT1.Castagna M, Soragna A, Mari SA, Santacroce M, Betté S, Mandela PG, Rudnick G, Peres A, Sacchi VF. Am J Physiol Cell Physiol. 2007 Oct; 2007 Jul 11. PMID: 17626242.
• What is an antidepressant binding site doing in a bacterial transporter?Rudnick G. ACS Chem Biol. 2007 Sep 21. PMID: 17894444.
• Identification of a chloride ion binding site in Na+/Cl -dependent transporters.Forrest LR, Tavoulari S, Zhang YW, Rudnick G, Honig B. Proc Natl Acad Sci U S A. 2007 Jul 31; 2007 Jul 24. PMID: 17652169.
• Phosphorylation of threonine residue 276 is required for acute regulation of serotonin transporter by cyclic GMP.Ramamoorthy S, Samuvel DJ, Buck ER, Rudnick G, Jayanthi LD. J Biol Chem. 2007 Apr 20; 2007 Feb 19. PMID: 17310063.
• The cytoplasmic substrate permeation pathway of serotonin transporter.Zhang YW, Rudnick G. J Biol Chem. 2006 Nov 24; 2006 Sep 28. PMID: 17008313.
• Serotonin transporters--structure and function.Rudnick G. J Membr Biol. 2006; 2007 Apr 6. PMID: 17417703.
• Structure/function relationships in serotonin transporter: new insights from the structure of a bacterial transporter.Rudnick G. Handb Exp Pharmacol. 2006. PMID: 16722230.
• Serotonin transporter mutations associated with obsessive-compulsive disorder and phosphorylation alter binding affinity for inhibitors.Zhang YW, Rudnick G. Neuropharmacology. 2005 Nov; 2005 Aug 19. PMID: 16112691.
• Cysteine-scanning mutagenesis of serotonin transporter intracellular loop 2 suggests an alpha-helical conformation.Zhang YW, Rudnick G. J Biol Chem. 2005 Sep 2; 2005 Jul 1. PMID: 15994310.
• Cysteine-scanning mutagenesis of the fifth external loop of serotonin transporter.Keller PC 2nd, Stephan M, Glomska H, Rudnick G. Biochemistry. 2004 Jul 6. PMID: 15222762.
• Analysis of transmembrane domain 2 of rat serotonin transporter by cysteine scanning mutagenesis.Sato Y, Zhang YW, Androutsellis-Theotokis A, Rudnick G. J Biol Chem. 2004 May 28; 2004 Mar 25. PMID: 15044496.
• Serotonin transporter: gene, genetic disorders, and pharmacogenetics.Murphy DL, Lerner A, Rudnick G, Lesch KP. Mol Interv. 2004 Apr. PMID: 15087484.
• Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype.Ozaki N, Goldman D, Kaye WH, Plotnicov K, Greenberg BD, Lappalainen J, Rudnick G, Murphy DL. Mol Psychiatry. 2003 Nov. PMID: 14593431.
• A human serotonin transporter mutation causes constitutive activation of transport activity.Kilic F, Murphy DL, Rudnick G. Mol Pharmacol. 2003 Aug. PMID: 12869649.
• A second site rescue mutation partially restores functional expression to the serotonin transporter mutant V382P.Visiers I, Weinstein H, Rudnick G, Stephan MM. Biochemistry. 2003 Jun 10. PMID: 12779333.
• Functional consequences of homo- but not hetero-oligomerization between transporters for the biogenic amine neurotransmitters.Kocabas AM, Rudnick G, Kilic F. J Neurochem. 2003 Jun. PMID: 12787070.
• Characterization of a functional bacterial homologue of sodium-dependent neurotransmitter transporters.Androutsellis-Theotokis A, Goldberg NR, Ueda K, Beppu T, Beckman ML, Das S, Javitch JA, Rudnick G. J Biol Chem. 2003 Apr 11; 2003 Feb 4. PMID: 12569103.
• Accessibility and conformational coupling in serotonin transporter predicted internal domains.Androutsellis-Theotokis A, Rudnick G. J Neurosci. 2002 Oct 1. PMID: 12351711.
• A conformationally sensitive residue on the cytoplasmic surface of serotonin transporter.Androutsellis-Theotokis A, Ghassemi F, Rudnick G. J Biol Chem. 2001 Dec 7. PMID: 11592963.
• The NH(2)-terminus of norepinephrine transporter contains a basolateral localization signal for epithelial cells.Gu HH, Wu X, Giros B, Caron MG, Caplan MJ, Rudnick G. Mol Biol Cell. 2001 Dec. PMID: 11739781.
• A lithium-induced conformational change in serotonin transporter alters cocaine binding, ion conductance, and reactivity of Cys-109.Ni YG, Chen JG, Androutsellis-Theotokis A, Huang CJ, Moczydlowski E, Rudnick G. J Biol Chem. 2001 Aug 17; 2001 Jun 14. PMID: 11408487.
• Functional role of critical stripe residues in transmembrane span 7 of the serotonin transporter. Effects of Na+, Li+, and methanethiosulfonate reagents.Kamdar G, Penado KM, Rudnick G, Stephan MM. J Biol Chem. 2001 Feb 9; 2000 Oct 31. PMID: 11058600.
• Evidence for a Black Hole and Accretion Disk in the LINER NGC 4203.Shields JC, Rix HW, McIntosh DH, Ho LC, Rudnick G, Filippenko AV, Sargent WL, Sarzi M. Astrophys J. 2000 May 1. PMID: 10790063.
• Oligomerization of serotonin transporter and its functional consequences.Kilic F, Rudnick G. Proc Natl Acad Sci U S A. 2000 Mar 28. PMID: 10716733.
• Permeation and gating residues in serotonin transporter.Chen JG, Rudnick G. Proc Natl Acad Sci U S A. 2000 Feb 1. PMID: 10655481.