Latest News
While current microscopy techniques image only a few intracellular molecules at a time, a new technique developed by Yale scientists can help researchers visualize the entire subcellular ecosystem.
- March 28, 2024Source: Cell
Super-resolution microscopy reveals the local distribution of proteins inside cells at the nanoscale but is in practice limited to visualizing only 2 to 3 different proteins in the same cell. FLASH-PAINT breaks this limit and empowers cell biologists to interrogate the complex spatial relationships between an essentially unlimited number of different molecules.
- June 16, 2023
Dr. Schuman talks about why she is inspired by neuroscience and the obstacles that she encountered along her impressive career.
- December 01, 2022Source: Advanced Science News
Scientists at Yale University have developed a "plasma membrane-on-a-chip" technology to study cell membranes more accurately. The cell membrane is crucial for cell function and is targeted by many drugs. Traditional methods have limitations, but this new silicon-based chip supports studying harvested cell membranes while maintaining lipid and protein asymmetry. Researchers can study protein and lipid behavior in these membranes, gaining insights into cell function and drug interactions. This technology has potential for advancing medicine development.
- May 31, 2021Source: Nature Methods
Light microscopy is traditionally limited by diffraction to about 250 nm resolution in the focal plane and more than 500 nm in depth. Super-resolution STED microscopy has overcome this diffraction limit but achieving sub-100 nm super-resolution in 3D in the middle of a tissue section has been impossible due to the optical aberrations the tissue introduces into the optical beam path. Introducing adaptive optics into an isoSTED microscope, an instrument that utilizes two opposing objectives for optimal 3D resolution, allowed the authors to correct for these aberrations. Using this instrument, they were able to obtain for the first time multi-color sub-50 nm 3D resolution images in samples as complex as Drosophila egg chambers and mouse brain tissue sections.
- September 21, 2020Source: Clear+Vivid with Alan Alda
Podcast Episode · Clear+Vivid with Alan Alda · 09/22/2020 · 38m
- April 11, 2017
James E. Rothman, newly appointed as a Sterling Professor of Cell Biology, is one of the world's most distinguished biochemists and cell biologists. For his work on how molecular messages are transmitted inside and outside of human cells, he was awarded a Nobel Prize in 2013.
- October 14, 2013
James E. Rothman, ’71 B.S., the Fergus F. Wallace Professor of Biomedical Sciences, and professor and chair of the Department of Cell Biology at Yale University, was awarded the 2013 Nobel Prize in Physiology or Medicine for his work on how molecular messages are transmitted inside and outside of our cells, the Royal Swedish National Academy announced today (Oct.7).
- November 30, 2010Source: Medicine@Yale
James E. Rothman, Ph.D., the Fergus F. Wallace Professor of Biomedical Sciences and chair of the Department of Cell Biology, has been awarded both the E.B. Wilson Medal and the Massry Prize for his seminal contributions to the field of cell biology.
- June 03, 2010
Yale cell biologist James E. Rothman today has been named one of three recipients awarded the 2010 Kavli Prize in Neuroscience, the second consecutive time a Yale scientist has been a co-recipient of the prestigious, biennial $1 million prize.