Rizzolo Lab Publications

• Tibial plateau fractures are associated with ligamentous and meniscal injuries. Preoperative evaluation of magnetic resonance imaging influences surgical treatment.Risitano S, Giustra F, Bosco F, Rea A, Cacciola G, Rizzolo R, Sabatini L, Capella M, Massè A. Eur J Trauma Emerg Surg. 2024 Oct; 2024 Jun 26. PMID: 38926170.
• Retinal Cell Transplantation, Biomaterials, and In Vitro Models for Developing Next-generation Therapies of Age-related Macular Degeneration.Rizzolo LJ, Nasonkin IO, Adelman RA. Stem Cells Transl Med. 2022 Mar 31. PMID: 35356975.
• Analysis of Population Representation Among Willed Whole-Body Donors to Facilitate the Construction of a Body Donation Program in China: From the Perspective of Medical Students and Anatomists.Zhang H, Chen K, Wang N, Zhang D, Zhang Q, Tang K, Wan M, Gong C, Hong X, Qiu W, Rizzolo LJ, Ma C. Omega (Westport). 2022 Mar; 2020 Jun 9. PMID: 32515268.
• Altered transcriptome and disease-related phenotype emerge only after fibroblasts harvested from patients with age-related macular degeneration are differentiated into retinal pigment epithelium.Cai H, Gong J, Noggle S, Paull D, Rizzolo LJ, Del Priore LV, Fields MA. Exp Eye Res. 2021 Jun; 2021 Apr 22. PMID: 33895162.
• Knockdown of Claudin-19 in the Retinal Pigment Epithelium Is Accompanied by Slowed Phagocytosis and Increased Expression of SQSTM1.Liu F, Peng S, Adelman RA, Rizzolo LJ. Invest Ophthalmol Vis Sci. 2021 Feb 1. PMID: 33591357.
• Partially Differentiated Neuroretinal Cells Promote Maturation of the Retinal Pigment Epithelium.Singh D, Chen X, Xia T, Ghiassi-Nejad M, Tainsh L, Adelman RA, Rizzolo LJ. Invest Ophthalmol Vis Sci. 2020 Nov 2. PMID: 33151282.
• Unstimulated, Serum-free Cultures of Retinal Pigment Epithelium Excrete Large Mounds of Drusen-like Deposits.Chen X, Singh D, Adelman RA, Rizzolo LJ. Curr Eye Res. 2020 Nov; 2020 Mar 30. PMID: 32202447.
• Claudins regulate gene and protein expression of the retinal pigment epithelium independent of their association with tight junctions.Liu F, Xu T, Peng S, Adelman RA, Rizzolo LJ. Exp Eye Res. 2020 Sep; 2020 Jul 23. PMID: 32712183.
• Interactions of the choroid, Bruch's membrane, retinal pigment epithelium, and neurosensory retina collaborate to form the outer blood-retinal-barrier.Fields MA, Del Priore LV, Adelman RA, Rizzolo LJ. Prog Retin Eye Res. 2020 May; 2019 Nov 5. PMID: 31704339.
• Stem cell-derived retinal pigment epithelium from patients with age-related macular degeneration exhibit reduced metabolism and matrix interactions.Gong J, Cai H, Noggle S, Paull D, Rizzolo LJ, Del Priore LV, Fields MA. Stem Cells Transl Med. 2020 Mar; 2019 Dec 16. PMID: 31840941.
• Disease-associated mutations of claudin-19 disrupt retinal neurogenesis and visual function.Wang SB, Xu T, Peng S, Singh D, Ghiassi-Nejad M, Adelman RA, Rizzolo LJ. Commun Biol. 2019; 2019 Mar 25. PMID: 30937396.
• A biodegradable scaffold enhances differentiation of embryonic stem cells into a thick sheet of retinal cells.Singh D, Wang SB, Xia T, Tainsh L, Ghiassi-Nejad M, Xu T, Peng S, Adelman RA, Rizzolo LJ. Biomaterials. 2018 Feb; 2017 Oct 31. PMID: 29128844.
• Neferine, is not inducer but blocker for macroautophagic flux targeting on lysosome malfunction.Xu T, Singh D, Liu J, Li H, Peng S, Rizzolo LJ, Wang SB. Biochem Biophys Res Commun. 2018 Jan 1; 2017 Nov 29. PMID: 29197576.
• Effects of diabetic retinopathy on the barrier functions of the retinal pigment epithelium.Xia T, Rizzolo LJ. Vision Res. 2017 Oct; 2017 Mar 30. PMID: 28347688.
• Claudin-3 and claudin-19 partially restore native phenotype to ARPE-19 cells via effects on tight junctions and gene expression.Peng S, Wang SB, Singh D, Zhao PY, Davis K, Chen B, Adelman RA, Rizzolo LJ. Exp Eye Res. 2016 Oct; 2016 Sep 1. PMID: 27593915.
• Human Adult Retinal Pigment Epithelial Stem Cell-Derived RPE Monolayers Exhibit Key Physiological Characteristics of Native Tissue.Blenkinsop TA, Saini JS, Maminishkis A, Bharti K, Wan Q, Banzon T, Lotfi M, Davis J, Singh D, Rizzolo LJ, Miller S, Temple S, Stern JH. Invest Ophthalmol Vis Sci. 2015 Nov. PMID: 26540654.
• The student's dilemma, liver edition: incorporating the sonographer's language into clinical anatomy education.Hall MK, Mirjalili SA, Moore CL, Rizzolo LJ. Anat Sci Educ. 2015 May-Jun; 2015 Jan 8. PMID: 25573229.
• TRP Channels Localize to Subdomains of the Apical Plasma Membrane in Human Fetal Retinal Pigment Epithelium.Zhao PY, Gan G, Peng S, Wang SB, Chen B, Adelman RA, Rizzolo LJ. Invest Ophthalmol Vis Sci. 2015 Mar 3; 2015 Mar 3. PMID: 25736794.
• Barrier properties of cultured retinal pigment epithelium.Rizzolo LJ. Exp Eye Res. 2014 Sep; 2014 Apr 14. PMID: 24731966.
• Engineering a blood-retinal barrier with human embryonic stem cell-derived retinal pigment epithelium: transcriptome and functional analysis.Peng S, Gan G, Qiu C, Zhong M, An H, Adelman RA, Rizzolo LJ. Stem Cells Transl Med. 2013 Jul; 2013 Jun 3. PMID: 23734062.
• Effects of proinflammatory cytokines on the claudin-19 rich tight junctions of human retinal pigment epithelium.Peng S, Gan G, Rao VS, Adelman RA, Rizzolo LJ. Invest Ophthalmol Vis Sci. 2012 Jul 27; 2012 Jul 27. PMID: 22761260.
• Differential expression of claudins in retinas during normal development and the angiogenesis of oxygen-induced retinopathy.Luo Y, Xiao W, Zhu X, Mao Y, Liu X, Chen X, Huang J, Tang S, Rizzolo LJ. Invest Ophthalmol Vis Sci. 2011 Sep 29; 2011 Sep 29. PMID: 21862644.
• Integration of tight junctions and claudins with the barrier functions of the retinal pigment epithelium.Rizzolo LJ, Peng S, Luo Y, Xiao W. Prog Retin Eye Res. 2011 Sep; 2011 Jun 17. PMID: 21704180.
• Claudin-19 and the barrier properties of the human retinal pigment epithelium.Peng S, Rao VS, Adelman RA, Rizzolo LJ. Invest Ophthalmol Vis Sci. 2011 Mar; 2011 Mar 14. PMID: 21071746.
• Effectiveness of a shortened, clinically engaged anatomy course for physician assistant students.Rizzolo LJ, Rando WC, O'Brien MK, Garino A, Stewart WB. Anat Sci Educ. 2011 Mar-Apr; 2011 Feb 18. PMID: 21337718.
• Minimal effects of VEGF and anti-VEGF drugs on the permeability or selectivity of RPE tight junctions.Peng S, Adelman RA, Rizzolo LJ. Invest Ophthalmol Vis Sci. 2010 Jun; 2009 Dec 30. PMID: 20042644.
• Design, implementation, and evaluation of an innovative anatomy course.Rizzolo LJ, Rando WC, O'Brien MK, Haims AH, Abrahams JJ, Stewart WB. Anat Sci Educ. 2010 May-Jun. PMID: 20496432.
• The 2008 anatomy ceremony: essays.Elansary M, Goldberg B, Qian T, Rizzolo LJ. Yale J Biol Med. 2009 Mar. PMID: 19325944.
• A novel rabbit model for studying RPE transplantation.Cong L, Sun D, Zhang Z, Jiao W, Rizzolo LJ, Peng S. Invest Ophthalmol Vis Sci. 2008 Sep; 2008 May 23. PMID: 18502985.
• Anatomists debate the value of a teaching credential.Rizzolo LJ, Drake RL. Anat Sci Educ. 2008 Mar-Apr. PMID: 19177383.
• Diffusible retinal secretions regulate the expression of tight junctions and other diverse functions of the retinal pigment epithelium.Sun R, Peng S, Chen X, Zhang H, Rizzolo LJ. Mol Vis. 2008; 2008 Dec 8. PMID: 19057659.
• Analysis of the RPE transcriptome reveals dynamic changes during the development of the outer blood-retinal barrier.Rizzolo LJ, Chen X, Weitzman M, Sun R, Zhang H. Mol Vis. 2007 Jul 23; 2007 Jul 23. PMID: 17679949.
• Development and role of tight junctions in the retinal pigment epithelium.Rizzolo LJ. Int Rev Cytol. 2007. PMID: 17338922.
• Should we continue teaching anatomy by dissection when ...?Rizzolo LJ, Stewart WB. Anat Rec B New Anat. 2006 Nov. PMID: 17109419.
• Expression of JAM-A, AF-6, PAR-3 and PAR-6 during the assembly and remodeling of RPE tight junctions.Luo Y, Fukuhara M, Weitzman M, Rizzolo LJ. Brain Res. 2006 Sep 19; 2006 Jul 21. PMID: 16859655.
• Effects of culture conditions on heterogeneity and the apical junctional complex of the ARPE-19 cell line.Luo Y, Zhuo Y, Fukuhara M, Rizzolo LJ. Invest Ophthalmol Vis Sci. 2006 Aug. PMID: 16877439.
• Anatomical instruction and training for professionalism from the 19th to the 21st centuries.Warner JH, Rizzolo LJ. Clin Anat. 2006 Jul. PMID: 16617459.
• Design principles for developing an efficient clinical anatomy course.Rizzolo LJ, Stewart WB, O'Brien M, Haims A, Rando W, Abrahams J, Dunne S, Wang S, Aden M. Med Teach. 2006 Mar. PMID: 16707295.
• The apical and basal environments of the retinal pigment epithelium regulate the maturation of tight junctions during development.Rahner C, Fukuhara M, Peng S, Kojima S, Rizzolo LJ. J Cell Sci. 2004 Jul 1. PMID: 15226402.
• Apical and basal regulation of the permeability of the retinal pigment epithelium.Peng S, Rahner C, Rizzolo LJ. Invest Ophthalmol Vis Sci. 2003 Feb. PMID: 12556417.
• Human dissection: an approach to interweaving the traditional and humanistic goals of medical education.Rizzolo LJ. Anat Rec. 2002 Dec 15. PMID: 12467081.
• Correlation of Web usage and exam performance in a human anatomy and development course.Rizzolo LJ, Aden M, Stewart WB. Clin Anat. 2002 Aug. PMID: 12203379.
• Claudin 5 is transiently expressed during the development of the retinal pigment epithelium.Kojima S, Rahner C, Peng S, Rizzolo LJ. J Membr Biol. 2002 Mar 15. PMID: 11944085.
• Defects in the MITF(mi/mi) apical surface are associated with a failure of outer segment elongation.Bumsted KM, Rizzolo LJ, Barnstable CJ. Exp Eye Res. 2001 Sep. PMID: 11520113.
• Differential regulation of tight junction permeability during development of the retinal pigment epithelium.Ban Y, Rizzolo LJ. Am J Physiol Cell Physiol. 2000 Sep. PMID: 10942725.
• Regulation of glucose transporters during development of the retinal pigment epithelium.Ban Y, Rizzolo LJ. Brain Res Dev Brain Res. 2000 May 11. PMID: 10837896.
• Two secreted retinal factors regulate different stages of development of the outer blood-retinal barrier.Ban Y, Wilt SD, Rizzolo LJ. Brain Res Dev Brain Res. 2000 Feb 7. PMID: 10675776.
• Polarization of the Na+, K(+)-ATPase in epithelia derived from the neuroepithelium.Rizzolo LJ. Int Rev Cytol. 1999. PMID: 9750268.
• Protein-binding domains of the tight junction protein, ZO-2, are highly conserved between avian and mammalian species.Collins JR, Rizzolo LJ. Biochem Biophys Res Commun. 1998 Nov 27. PMID: 9837755.
• A culture model of development reveals multiple properties of RPE tight junctions.Ban Y, Rizzolo LJ. Mol Vis. 1997 Dec 31; 1997 Dec 31. PMID: 9479009.
• Remodeling of junctional complexes during the development of the outer blood-retinal barrier.Williams CD, Rizzolo LJ. Anat Rec. 1997 Nov. PMID: 9372172.
• Polarity and the development of the outer blood-retinal barrier.Rizzolo LJ. Histol Histopathol. 1997 Oct. PMID: 9302567.
• Differentiation and transdifferentiation of the retinal pigment epithelium.Zhao S, Rizzolo LJ, Barnstable CJ. Int Rev Cytol. 1997. PMID: 9066129.
• The distribution of Na+,K(+)-ATPase and 5A11 antigen in apical microvilli of the retinal pigment epithelium is unrelated to alpha-spectrin.Rizzolo LJ, Zhou S. J Cell Sci. 1995 Nov. PMID: 8586673.
• The neural retina maintains integrins in the apical membrane of the RPE early in development.Rizzolo LJ, Zhou S, Li ZQ. Invest Ophthalmol Vis Sci. 1994 Apr. PMID: 8163344.
• Diffusible, retinal factors stimulate the barrier properties of junctional complexes in the retinal pigment epithelium.Rizzolo LJ, Li ZQ. J Cell Sci. 1993 Nov. PMID: 8308068.
• Apical orientation of the microtubule organizing center and associated gamma-tubulin during the polarization of the retinal pigment epithelium in vivo.Rizzolo LJ, Joshi HC. Dev Biol. 1993 May. PMID: 8482407.
• Basement membrane stimulates the polarized distribution of integrins but not the Na,K-ATPase in the retinal pigment epithelium.Rizzolo LJ. Cell Regul. 1991 Nov. PMID: 1667092.
• The polarity of the retinal pigment epithelium is developmentally regulated.Rizzolo LJ, Heiges M. Exp Eye Res. 1991 Oct. PMID: 1657628.
• The distribution of Na+,K(+)-ATPase in the retinal pigmented epithelium from chicken embryo is polarized in vivo but not in primary cell culture.Rizzolo LJ. Exp Eye Res. 1990 Oct. PMID: 2170160.
• A growth hormone-vesicular stomatitis virus G hybrid protein is rapidly degraded in lysosomes following transport to the cell surface.Rizzolo LJ. Eur J Cell Biol. 1989 Jun. PMID: 2547615.
• Post-translational protein modification in the endoplasmic reticulum. Demonstration of fatty acylase and deoxymannojirimycin-sensitive alpha-mannosidase activities.Rizzolo LJ, Kornfeld R. J Biol Chem. 1988 Jul 5. PMID: 2967826.
• The influenza hemagglutinin insertion signal is not cleaved and does not halt translocation when presented to the endoplasmic reticulum membrane as part of a translocating polypeptide.Finidori J, Rizzolo L, Gonzalez A, Kreibich G, Adesnik M, Sabatini DD. J Cell Biol. 1987 Jun. PMID: 3294860.
• Nonpolarized secretion of truncated forms of the influenza hemagglutinin and the vesicular stomatitus virus G protein from MDCK cells.Gonzalez A, Rizzolo L, Rindler M, Adesnik M, Sabatini DD, Gottlieb T. Proc Natl Acad Sci U S A. 1987 Jun. PMID: 3035552.
• Secretion of endogenous and exogenous proteins from polarized MDCK cell monolayers.Gottlieb TA, Beaudry G, Rizzolo L, Colman A, Rindler M, Adesnik M, Sabatini DD. Proc Natl Acad Sci U S A. 1986 Apr. PMID: 3083413.
• Sorting and endocytosis of viral glycoproteins in transfected polarized epithelial cells.Gottlieb TA, Gonzalez A, Rizzolo L, Rindler MJ, Adesnik M, Sabatini DD. J Cell Biol. 1986 Apr. PMID: 3007530.
• Biosynthesis and intracellular sorting of growth hormone-viral envelope glycoprotein hybrids.Rizzolo LJ, Finidori J, Gonzalez A, Arpin M, Ivanov IE, Adesnik M, Sabatini DD. J Cell Biol. 1985 Oct. PMID: 2995406.
• Kinetics and protein subunit interactions of Escherichia coli phosphatidylserine decarboxylase in detergent solution.Rizzolo LJ. Biochemistry. 1981 Feb 17. PMID: 7011377.
• Behavior of fragmented calcium (II) adenosine triphosphatase from sarcoplasmic reticulum in detergent solution.Rizzolo LJ, Tanford C. Biochemistry. 1978 Sep 19. PMID: 152120.
• Denaturation of the tryptic fragments of the calcium (II) adenosine triphosphatase from sarcoplasmic reticulum by guanidinium hydrochloride.Rizzolo LJ, Tanford C. Biochemistry. 1978 Sep 19. PMID: 152119.
• Molecular weights and hydrophobicity of the polypeptide chain of sarcoplasmic reticulum calcium(II) adenosine triphosphatase and of its primary tryptic fragments.Rizzolo LJ, Maire M, Reynolds JA, Tanford C. Biochemistry. 1976 Aug 10. PMID: 133715.