Publications

¹Hong Z, ¹Adlakha J, Wan N, Guinn E, Giska F, Gupta K, Melia TJ, Reinisch KM. Mitoguardin-2-mediated lipid transfer preserves mitochondrial morphology and lipid droplet formation. J Cell Biol. 2022; 221(12):e202207022. doi: 10.1083/jcb.202207022. PMID36282247.
¹Hanna MG, ¹Suen PH, Wu Y, *Reinisch KM, *De Camilli P. SHIP164 is a chorein motif lipid transfer protein that controls endosome-Golgi membrane traffic. J Cell Biol. 2022 Jun 6;221(6):e202111018. doi: 10.1083/jcb.202111018. PMID35499567.
¹Adlakha J, ¹Hong Z, Li P, Reinisch KM. Structural and biochemical insights into lipid transport by VPS13 proteins. J Cell Biol. 2022; 221(5):e202202030. doi: 10.1083/jcb.202202030. PMID35357422.
*Melia TJ, *Reinisch KM. A possible role for VPS13-family proteins in bulk lipid transfer, membrane expansion and organelle biogenesis. J Cell Sci. 2022;135(5):jcs259357. doi: 10.1242/jcs.259357. PMID35267021.
*Reinisch KM, *Melia TJ . "VTT"-domain proteins VMP1 and TMEM41B function in lipid homeostasis globally and locally as ER scramblases. Contact 2021; 4:10.1177/25152564211024494. doi: 10.1177/25152564211024494. PMID34447902.
¹Ghanbarpour A, ¹Valverde DP, *Melia TJ, *Reinisch KM. A model for a partnership of lipid transfer proteins and scramblases in membrane expansion and organelle biogenesis. Proc Natl Acad Sci U S A. 2021; 118(16):e2101562118. doi: 10.1073/pnas.2101562118. PMID33850023.
*Leonzino M, *Reinisch KM, *De Camilli P. Insights into VPS13 properties and function reveal a new mechanism of eukaryotic lipid transport. Biochim Biophys Acta Mol Cell Biol Lipids. 2021;1866(10):159003. doi: 10.1016/j.bbalip.2021.159003. PMID34216812.
*Reinisch KM, *Prinz WA. Mechanisms of nonvesicular lipid transport. J Cell Biol. 2021;220(3):e202012058. doi: 10.1083/jcb.202012058. PMID33605998.
¹Lees JA, 1Li P, Kumar N, Weisman LS, Reinisch KM. Insights into Lysosomal PI(3,5)P2 Homeostasis from a Structural-Biochemical Analysis of the PIKfyve Lipid Kinase Complex. Mol Cell. 2020; 80(4):736-743.e4. doi: 10.1016/j.molcel.2020.10.003. PMID33098764.
*Lees JA, *Reinisch KM. Inter-organelle lipid transfer: a channel model for Vps13 and chorein-N motif proteins. Curr Opin Cell Biol. 2020; 65:66-71. doi: 10.1016/j.ceb.2020.02.008. PMID32213462; PMC7885529.
Li P., Lees JA., Lusk CP., Reinisch KM., Cryo-EM reconstruction of a VPS13 fragment reveals a long groove to channel lipids between membranes. J Cell Biol. 2020 May 4; jcb. 202001161.
Scorrano L, De Matteis MA, Emr S, Giordano F, Hajnóczky G, Kornmann B, Lackner LL, Levine TP, Pellegrini L, Reinisch K, Rizzuto R, Simmen T, Stenmark H, Ungermann C, Schuldiner M. Coming together to define membrane contact sites. Nat Commun. 2019;10(1):1287. doi: 10.1038/s41467-019-09253-3. PMID30894536.
Valverde DP.¹, Yu S.¹, Boggavarapu V., Kumar N., Lees JA., Walz* T., Reinisch* KM., Melia* TJ. ATG2 transports lipids to promote autophagosome biogenesis. J Cell Biol. 2019 Apr 5;jcb. 201811139. ¹co-first authors, *co-corresponding authors.
Kumar N.¹, Leonzino M.¹, Hancock-Cerutti W., Horenkamp FA, Li P, Wheeler H, Reinisch* KM. VPS13A and VPS13C are lipid transfer proteins differentially localized at ER contact sites. J Cell Biol. 2018 Aug 9;jcb. 201807019. ¹co-first authors, *co-corresponding authors.
Horenkamp FA.¹, Valverde DP.¹, Nunnari J, Reinisch* KM. Molecular basis for sterol transport by StART-like lipid transfer domains. EMBO J. 2018 Mar 15;37(6). ¹co-first authors, *co-corresponding authors.
Lees JA.¹, Zhang Y.¹, Oh MS., Schauder CM., Yu X., Baskin JM., Dobbs K., Notarangelo LD., De Camilli* P., Walz* T., Reinisch* KM.Architecture of the human PI4KIIIα lipid kinase complex. PNAS 2017 Dec 26;114(52):13720-25. ¹co-first authors, *co-corresponding authors.
Lees JA.¹, Messa M.¹, Sun EW., Wheeler H., Torta F., Wenk MR., De Camilli* P., Reinisch* KM. Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion. Science. 2017 Feb 17;355(6326). ¹co-first authors, *co-corresponding authors.
Baskin JM.¹, Wu X.¹, Christiano R., Oh MS., Schauder CM., Gazzerro E., Messa M., Baldassari S., Assereto S., Biancheri R., Zara F., Minetti C., Raimondi A., Simons M., Walther TC., Reinisch* KM., De Camilli* P. The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane. Nature Cell Biology 2016, Jan;18(1):132-8. ¹co-first authors, *co-corresponding authors.
Horenkamp FA., Kauffman KJ., Kohler LJ., Sherwood RK., Krueger KP., Shteyn V., Roy CR., Melia* TJ., Reinisch* K.M. The Legionella Anti-autophagy Effector RavZ Targets the Autophagosome via PI3P- and Curvature-Sensing Motifs. Dev Cell 2015, 14;34(5):569-76. *co-corresponding authors.
Krishnakumar* SS., Li F., Coleman J., Schauder CM., Kümmel D., Pincet F., Rothman JE., Reinisch* K.M. Re-visiting the trans insertion model for complexin clamping. Elife 2015 Apr 2;4. *co-corresponding authors.
Cai Y., Deng Y., Horenkamp F., Reinisch* K.M., Burd* C.G. Sac1-Vps74 structure reveals a mechanism to terminate phosphoinositide signaling in the Golgi apparatus. JCB 2014, 206:485-91. *co-corresponding authors.
Schauder C.M., Wu X., Saheki Y., Narayanaswamy P., Torta F., Wenk M.R., De Camilli* P., Reinisch* K.M. Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer. Nature 2014, 510:552-55. *co-corresponding authors.
Langemeyer L., Nunes Bastos R., Cai Y., Itzen A., Reinisch K.M., Barr F.A. Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation. eLife 2014, 3:e01623
Horenkamp F.A., Mukherjee S., Alix E., Schauder C.M., Hubber A.M., Roy C.R., Reinisch K.M. Legionella pneumophila subversion of host vesicular transport by SidC effector proteins. Traffic 2014, 15:488-99.
Wu X., Chi R.J., Baskin J.M., Lucast L., Burd C.G., De Camilli P., Reinisch K.M. Structural insights into assembly and regulation of the plasma membrane phosphatidylinositol 4-kinase complex. Dev. Cell 2014, 28:19-29.
Tan D.¹, Cai Y¹, Wang J., Zhang J., Menon S., Chou H.T., Ferro-Novick S.*, Reinisch K.M.*, Walz T*. The EM structure of the TRAPPIII complex leads to the identification of a requirement for COPII vesicles on the macroautophagy pathway. PNAS 2013, 110:19432-7. ¹co-first authors, *co-corresponding authors.
Wu, X., Bradley, M.J., Kümmel, D., Cai, Y., De La Cruz, E.M., Barr, F.A., Reinisch, K.M. Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate. PNAS 2011, 108:18672-18677.
Kümmel, D., Krishnakumar, S.S., Radoff, D.T., Li, F., Giraudo, C.G., Pincet, F., Rothman*, J.E., Reinisch*, K.M. Complexin cross-links pre-fusion SNAREs into a zig-zag assembly. NSMB 2011, 18:927-933. *co-corresponding authors.
Hughson, F.M. & Reinisch, K.M. Structure and mechanism in membrane trafficking. Curr. Opin. Cell Biol. 2010, 22:454-460.
Hamill, S., *Wolin, S.L., and *Reinisch, K.M. Structure and function of the polymerase core of TRAMP, a RNA surveillance complex. PNAS 2010, 107: 15045-15050. *co-corresponding authors.
Vasan, N., Hutagalung, A., Novick, P., and Reinisch, K.M. Structure of a C-terminal fragment of its Vps53 subunit suggests similarity of Golgi-associated retrograde protein (GARP) complex to a family of tethering complexes. PNAS 2010, 107: 14176-14181.
Sclafani, A., Chen, S., Rivera-Molina, F., Reinisch, K., Novick, P., Ferro-Novick, S. Establishing a role for the GTPase Ypt1 at the late Golgi. Traffic 2010, 11: 520-532.
Barrowman, J., Bhandari, D., Reinisch, K. & Ferro-Novick, S. TRAPP complexes in membrane traffic: convergence through a common Rab. Nat. Rev. Cell Biol. 2010, 11: 759-763.
Chin, H.F., Cai, Y., Menon, S., Ferro-Novick, S., Reinisch, K.M., De La Cruz, E.M. Kinetic analysis of TRAPP, a multimeric Ypt1p exchange factor. JMB 2009, 389: 275-288.
Dong, G., Wearsch, P.A., Peaper, D.R., Cresswell*, P., and Reinisch*, K.M. Insights into MHC class I peptide loading from the structure of the tapasin/ERp57 heterodimer. Immunity 2009, 30: 21-32. *co-corresponding authors.
Cai, Y., Chin, H.F., Lazarova, D., Menon, S., Fu, C., Sclafani, A., Cai, H., Rodgers, D.W., De La Cruz, E.M., Ferro-Novick*, S. & Reinisch*, K.M. The structural basis for the activation of the Rab Ypt1p by the TRAPP membrane tethering complexes. Cell 2008, 133:1202-1213. *co-corresponding authors.
Cai, H., Reinisch, K. & Ferro-Novick, S. Coats, tethers, Rabs, SNAREs work together to mediate the intracellular destination of a transport vesicle. Dev. Cell 2007, 12: 671-682.
Cai, H., Yu, S., Menon, S., Cai, Y., Lazarova, D., Fu, C., Reinisch, K., Hay, J.C. & Ferro-Novick, S. TRAPPI tethers COPII vesicles by binding the coat subunit Sec23. Nature 2007, 445: 941-944.
Dong, G., Medkova, M., Novick*, P. & Reinisch*, K.M. A catalytic coiled-coil: activation of the Rab GTPase Sec4p by Sec2p. Mol. Cell 2007, 25:455-462. *co-corresponding authors.
Wolin, S.L. & Reinisch, K.M.Emerging themes in non-coding RNA quality control. Curr. Opin. Struct. Biol. 2007, 17: 209-214.
Fuchs, G., Stein, A.J., Fu, C., Reinisch*, K.M. & Wolin*, S.L. Structural and biochemical basis for misfolded RNA recognition by the Ro autoantigen. Nat. Struct. Mol. Biol. 2006, 13:1002-1009. *co-corresponding authors.
Wolin, S.L. & Reinisch, K.M. The Ro 60kDa autoantigen comes into focus: interpreting epitope mapping experiments on the basis of structure. Autoimmun. Rev. 2006, 5: 367-372.
Dong, G., Hutagalung, A.H., Fu, C., Novick*, P. & Reinisch*, K.M. The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif. Nat. Struct. Mol. Biol. 2005, 12: 1094-1100. *co-corresponding authors
Stein, A.J., Fuchs, G., Fu, C., Wolin, S.L. & Reinisch, K.M. Structural insights into RNA quality control: the Ro autoantigen binds misfolded RNAs via its central cavity. Cell 2005, 121:529-539.
Dong, G., Chakshusmathi, G, Wolin, S.L. & Reinisch, K.M. Structure of the La motif: a winged helix domain mediates RNA binding via a conserved aromatic patch. EMBO J. 2004, 23:1000-1007.

Before 2002:

Reinisch, K.M. The dsRNA viridae and their catalytic capsids. Nat. Struct. Biol. 2002, 9: 714-716.
Reinisch, K.M., Nibert, M.L. & Harrison, S.C. Structure of the reovirus core at 3.6 Å resolution. Nature 2000, 404: 960-967.
Luongo, C.L., Reinisch, K.M., Harrison, S.C. & Nibert, M.L. Identification of the guanylyltransferase region and active site in reovirus mRNA capping protein lambda2. J. Biol. Chem. 2000, 275: 2804-2810.
Reinisch, K.M., Chen, L., Verdine, G.L. & Lipscomb, W.N. The crystal structure of HaeIII methyltransferase covalently complexed to DNA: an extrahelical cytosine and rearranged base pairing. Cell 1995, 82: 143-153.
Reinisch, K.M., Chen, L., Verdine, G.L. & Lipscomb, W.N. Crystallization and preliminary crystallographic analysis of a DNA (cytosine-5)-methyltransferase from Haemophilus aegyptius bound covalently to DNA. J. Mol. Biol. 1994, 238: 626-629.