- Research Focus
In the laboratory we study lung cancer to answer the following questions: What are the alterations in cellular pathways that cause tumors to form? How can we interfere with these pathways to get tumors to regress? How do tumors become resistant to drugs? How can we detect tumors early when they are still curable?
Not all lung cancers are the same. There are two major histopathological categories of lung cancer: non-small cell lung cancer and small cell lung cancer. Non-small cell lung cancer is the most common accounting for 80% of all lung cancers. NSCLC itself can be divided into three histological subtypes: adenocarcinoma, squamous cell carcinoma and large cell carcinoma. Lung adenocarcinomas are the most frequent and the genetics of these tumors has been studied extensively in recent years. In the lab we focus on one of the genes that is mutated in lung adenocarcinomas-the Epidermal Growth Factor Receptor (EGFR) gene