Publications
2022
- The thalamus and its subnuclei-a gateway to obsessive-compulsive disorder.Weeland CJ, Kasprzak S, de Joode NT, Abe Y, Alonso P, Ameis SH, Anticevic A, Arnold PD, Balachander S, Banaj N, Bargallo N, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Brecke V, Brem S, Cappi C, Cheng Y, Cho KIK, Costa DLC, Dallaspezia S, Denys D, Eng GK, Ferreira S, Feusner JD, Fontaine M, Fouche JP, Grazioplene RG, Gruner P, He M, Hirano Y, Hoexter MQ, Huyser C, Hu H, Jaspers-Fayer F, Kathmann N, Kaufmann C, Kim M, Koch K, Bin Kwak Y, Kwon JS, Lazaro L, Li CR, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minnuzi L, Moreira PS, Morgado P, Nakagawa A, Nakamae T, Narayanaswamy JC, Nurmi EL, Ortiz AE, Pariente JC, Piacentini J, Picó-Pérez M, Piras F, Piras F, Pittenger C, Reddy YCJ, Rodriguez-Manrique D, Sakai Y, Shimizu E, Shivakumar V, Simpson HB, Soreni N, Soriano-Mas C, Sousa N, Spalletta G, Stern ER, Stevens MC, Stewart SE, Szeszko PR, Takahashi J, Tanamatis T, Tang J, Thorsen AL, Tolin D, van der Werf YD, van Marle H, van Wingen GA, Vecchio D, Venkatasubramanian G, Walitza S, Wang J, Wang Z, Watanabe A, Wolters LH, Xu X, Yun JY, Zhao Q, White T, Thompson PM, Stein DJ, van den Heuvel OA, Vriend C. Transl Psychiatry. 2022 Feb 21; 2022 Feb 21. PMID: 35190533.
- Psychedelics.Kelmendi B, Kaye AP, Pittenger C, Kwan AC. Curr Biol. 2022 Jan 24. PMID: 35077687.
- Transcranial direct current stimulation targeting the medial prefrontal cortex modulates functional connectivity and enhances safety learning in obsessive-compulsive disorder: Results from two pilot studies.Adams TG, Cisler JM, Kelmendi B, George JR, Kichuk SA, Averill CL, Anticevic A, Abdallah CG, Pittenger C. Depress Anxiety. 2022 Jan; 2021 Aug 31. PMID: 34464485.
- An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration.van den Heuvel OA, Boedhoe PSW, Bertolin S, Bruin WB, Francks C, Ivanov I, Jahanshad N, Kong XZ, Kwon JS, O'Neill J, Paus T, Patel Y, Piras F, Schmaal L, Soriano-Mas C, Spalletta G, van Wingen GA, Yun JY, Vriend C, Simpson HB, van Rooij D, Hoexter MQ, Hoogman M, Buitelaar JK, Arnold P, Beucke JC, Benedetti F, Bollettini I, Bose A, Brennan BP, De Nadai AS, Fitzgerald K, Gruner P, Grünblatt E, Hirano Y, Huyser C, James A, Koch K, Kvale G, Lazaro L, Lochner C, Marsh R, Mataix-Cols D, Morgado P, Nakamae T, Nakao T, Narayanaswamy JC, Nurmi E, Pittenger C, Reddy YCJ, Sato JR, Soreni N, Stewart SE, Taylor SF, Tolin D, Thomopoulos SI, Veltman DJ, Venkatasubramanian G, Walitza S, Wang Z, Thompson PM, Stein DJ. Hum Brain Mapp. 2022 Jan; 2020 Mar 10. PMID: 32154629.
2021
- Treatment of obsessive-compulsive disorder with frontopolar multifocal transcranial direct current stimulation and exposure and response prevention: A case Series.Adams TG Jr, Rippey CS, Kelly AR, Gold BT, Pittenger C. Brain Stimul. 2021 Nov-Dec; 2021 Sep 23. PMID: 34563745.
- Electroencephalographic Correlates and Predictors of Treatment Outcome in OCD: A Brief Narrative Review.Zaboski BA, Stern EF, Skosnik PD, Pittenger C. Front Psychiatry. 2021; 2021 Aug 2. PMID: 34408681.
- OCD Influences Evidence Accumulation During Decision Making in Males but Not Females During Perceptual and Value-Driven Choice.Ma X, Megli A, Pittenger C, Pushkarskaya H. Front Psychiatry. 2021; 2021 Jul 29. PMID: 34393851.
- Mapping brain-behavior space relationships along the psychosis spectrum.Ji JL, Helmer M, Fonteneau C, Burt JB, Tamayo Z, Demšar J, Adkinson BD, Savić A, Preller KH, Moujaes F, Vollenweider FX, Martin WJ, Repovš G, Cho YT, Pittenger C, Murray JD, Anticevic A. Elife. 2021 Jul 20; 2021 Jul 20. PMID: 34313219.
- Inhibitory regulation of calcium transients in prefrontal dendritic spines is compromised by a nonsense Shank3 mutation.Ali F, Shao LX, Gerhard DM, Sweasy K, Pothula S, Pittenger C, Duman RS, Kwan AC. Mol Psychiatry. 2021 Jun; 2020 Mar 11. PMID: 32161363.
- Specialty knowledge and competency standards for pharmacotherapy for adult obsessive-compulsive disorder.Pittenger C, Brennan BP, Koran L, Mathews CA, Nestadt G, Pato M, Phillips KA, Rodriguez CI, Simpson HB, Skapinakis P, Stein DJ, Storch EA. Psychiatry Res. 2021 Jun; 2021 Mar 4. PMID: 33975093.
- Author Correction: Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines.Ali F, Gerhard DM, Sweasy K, Pothula S, Pittenger C, Duman RS, Kwan AC. Nat Commun. 2021 Jan 8; 2021 Jan 8. PMID: 33420087.
- Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity.Xu J, Liu RJ, Fahey S, Frick L, Leckman J, Vaccarino F, Duman RS, Williams K, Swedo S, Pittenger C. Am J Psychiatry. 2021 Jan 1; 2020 Jun 16. PMID: 32539528.
- Pharmacotherapeutic Strategies and New Targets in OCD.Pittenger C. Curr Top Behav Neurosci. 2021. PMID: 33751503.
2020
- Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium.Kong XZ, Boedhoe PSW, Abe Y, Alonso P, Ameis SH, Arnold PD, Assogna F, Baker JT, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Bose A, Brem S, Brennan BP, Buitelaar J, Calvo R, Cheng Y, Cho KIK, Dallaspezia S, Denys D, Ely BA, Feusner J, Fitzgerald KD, Fouche JP, Fridgeirsson EA, Glahn DC, Gruner P, Gürsel DA, Hauser TU, Hirano Y, Hoexter MQ, Hu H, Huyser C, James A, Jaspers-Fayer F, Kathmann N, Kaufmann C, Koch K, Kuno M, Kvale G, Kwon JS, Lazaro L, Liu Y, Lochner C, Marques P, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Medland SE, Menchón JM, Minuzzi L, Moreira PS, Morer A, Morgado P, Nakagawa A, Nakamae T, Nakao T, Narayanaswamy JC, Nurmi EL, O'Neill J, Pariente JC, Perriello C, Piacentini J, Piras F, Piras F, Pittenger C, Reddy YCJ, Rus-Oswald OG, Sakai Y, Sato JR, Schmaal L, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stern ER, Stevens MC, Stewart SE, Szeszko PR, Tolin DF, Tsuchiyagaito A, van Rooij D, van Wingen GA, Venkatasubramanian G, Wang Z, Yun JY, Thompson PM, Stein DJ, van den Heuvel OA, Francks C. Biol Psychiatry. 2020 Jun 15; 2019 Apr 30. PMID: 31178097.
- The histidine decarboxylase model of tic pathophysiology: a new focus on the histamine H3 receptor.Pittenger C. Br J Pharmacol. 2020 Feb; 2019 Mar 27. PMID: 30714121.
- Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines.Ali F, Gerhard DM, Sweasy K, Pothula S, Pittenger C, Duman RS, Kwan AC. Nat Commun. 2020 Jan 7; 2020 Jan 7. PMID: 31911591.
2019
- Animal models of OCD-relevant processes: an RDoC perspective.Pittenger C, Pushkarskaya H, Gruner P. J Obsessive Compuls Relat Disord. 2019 Oct; 2019 Apr 3. PMID: 32322462.
- Pharmacological antagonism of histamine H2R ameliorated L-DOPA-induced dyskinesia via normalization of GRK3 and by suppressing FosB and ERK in PD.Ahmed MR, Jayakumar M, Ahmed MS, Zamaleeva AI, Tao J, Li EH, Job JK, Pittenger C, Ohtsu H, Rajadas J. Neurobiol Aging. 2019 Sep; 2019 Jun 19. PMID: 31306812.
- Orbitofrontal Circuits Control Multiple Reinforcement-Learning Processes.Groman SM, Keistler C, Keip AJ, Hammarlund E, DiLeone RJ, Pittenger C, Lee D, Taylor JR. Neuron. 2019 Aug 21; 2019 Jun 25. PMID: 31253468.
- Imagery rescripting as an adjunct clinical intervention for obsessive compulsive disorder.Maloney G, Koh G, Roberts S, Pittenger C. J Anxiety Disord. 2019 Aug; 2019 Jul 18. PMID: 31357037.
- Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits.Katrancha SM, Shaw JE, Zhao AY, Myers SA, Cocco AR, Jeng AT, Zhu M, Pittenger C, Greer CA, Carr SA, Xiao X, Koleske AJ. Cell Rep. 2019 Mar 5. PMID: 30840899.
- Contrasting contributions of anhedonia to obsessive-compulsive, hoarding, and post-traumatic stress disorders.Pushkarskaya H, Sobowale K, Henick D, Tolin DF, Anticevic A, Pearlson GD, Levy I, Harpaz-Rotem I, Pittenger C. J Psychiatr Res. 2019 Feb; 2018 Dec 1. PMID: 30572276.
2018
- Striatal Signaling Regulated by the H3R Histamine Receptor in a Mouse Model of tic Pathophysiology.Rapanelli M, Frick L, Jindachomthong K, Xu J, Ohtsu H, Nairn AC, Pittenger C. Neuroscience. 2018 Nov 10; 2018 Sep 29. PMID: 30278251.
- Time course of clinical change following neurofeedback.Rance M, Walsh C, Sukhodolsky DG, Pittman B, Qiu M, Kichuk SA, Wasylink S, Koller WN, Bloch M, Gruner P, Scheinost D, Pittenger C, Hampson M. Neuroimage. 2018 Nov 1; 2018 May 2. PMID: 29729393.
- Disgust sensitivity mediates the effects of race on contamination aversion.George JR, Pittenger C, Kelmendi B, Lohr JM, Adams TG. J Obsessive Compuls Relat Disord. 2018 Oct; 2018 Aug 7. PMID: 31341759.
- Distinct but Synergistic Roles for Histone Deacetylase in the Dorsal Striatum During Habit Formation.Pittenger C, Taylor JR. Biol Psychiatry. 2018 Sep 1. PMID: 30115242.
- Developing image sets for inducing obsessive-compulsive checking symptoms.Brooks H, Kichuk SA, Adams TG, Koller WN, Eken HN, Rance M, Monahan S, Wasylink S, Kelmendi B, Pittenger C, Gruner P, Hampson M. Psychiatry Res. 2018 Jul; 2018 Apr 22. PMID: 29763844.
- Analysis of shared heritability in common disorders of the brain.Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, Lee PH, Turley P, Grenier-Boley B, Chouraki V, Kamatani Y, Berr C, Letenneur L, Hannequin D, Amouyel P, Boland A, Deleuze JF, Duron E, Vardarajan BN, Reitz C, Goate AM, Huentelman MJ, Kamboh MI, Larson EB, Rogaeva E, St George-Hyslop P, Hakonarson H, Kukull WA, Farrer LA, Barnes LL, Beach TG, Demirci FY, Head E, Hulette CM, Jicha GA, Kauwe JSK, Kaye JA, Leverenz JB, Levey AI, Lieberman AP, Pankratz VS, Poon WW, Quinn JF, Saykin AJ, Schneider LS, Smith AG, Sonnen JA, Stern RA, Van Deerlin VM, Van Eldik LJ, Harold D, Russo G, Rubinsztein DC, Bayer A, Tsolaki M, Proitsi P, Fox NC, Hampel H, Owen MJ, Mead S, Passmore P, Morgan K, Nöthen MM, Rossor M, Lupton MK, Hoffmann P, Kornhuber J, Lawlor B, McQuillin A, Al-Chalabi A, Bis JC, Ruiz A, Boada M, Seshadri S, Beiser A, Rice K, van der Lee SJ, De Jager PL, Geschwind DH, Riemenschneider M, Riedel-Heller S, Rotter JI, Ransmayr G, Hyman BT, Cruchaga C, Alegret M, Winsvold B, Palta P, Farh KH, Cuenca-Leon E, Furlotte N, Kurth T, Ligthart L, Terwindt GM, Freilinger T, Ran C, Gordon SD, Borck G, Adams HHH, Lehtimäki T, Wedenoja J, Buring JE, Schürks M, Hrafnsdottir M, Hottenga JJ, Penninx B, Artto V, Kaunisto M, Vepsäläinen S, Martin NG, Montgomery GW, Kurki MI, Hämäläinen E, Huang H, Huang J, Sandor C, Webber C, Muller-Myhsok B, Schreiber S, Salomaa V, Loehrer E, Göbel H, Macaya A, Pozo-Rosich P, Hansen T, Werge T, Kaprio J, Metspalu A, Kubisch C, Ferrari MD, Belin AC, van den Maagdenberg AMJM, Zwart JA, Boomsma D, Eriksson N, Olesen J, Chasman DI, Nyholt DR, Avbersek A, Baum L, Berkovic S, Bradfield J, Buono RJ, Catarino CB, Cossette P, De Jonghe P, Depondt C, Dlugos D, Ferraro TN, French J, Hjalgrim H, Jamnadas-Khoda J, Kälviäinen R, Kunz WS, Lerche H, Leu C, Lindhout D, Lo W, Lowenstein D, McCormack M, Møller RS, Molloy A, Ng PW, Oliver K, Privitera M, Radtke R, Ruppert AK, Sander T, Schachter S, Schankin C, Scheffer I, Schoch S, Sisodiya SM, Smith P, Sperling M, Striano P, Surges R, Thomas GN, Visscher F, Whelan CD, Zara F, Heinzen EL, Marson A, Becker F, Stroink H, Zimprich F, Gasser T, Gibbs R, Heutink P, Martinez M, Morris HR, Sharma M, Ryten M, Mok KY, Pulit S, Bevan S, Holliday E, Attia J, Battey T, Boncoraglio G, Thijs V, Chen WM, Mitchell B, Rothwell P, Sharma P, Sudlow C, Vicente A, Markus H, Kourkoulis C, Pera J, Raffeld M, Silliman S, Boraska Perica V, Thornton LM, Huckins LM, William Rayner N, Lewis CM, Gratacos M, Rybakowski F, Keski-Rahkonen A, Raevuori A, Hudson JI, Reichborn-Kjennerud T, Monteleone P, Karwautz A, Mannik K, Baker JH, O'Toole JK, Trace SE, Davis OSP, Helder SG, Ehrlich S, Herpertz-Dahlmann B, Danner UN, van Elburg AA, Clementi M, Forzan M, Docampo E, Lissowska J, Hauser J, Tortorella A, Maj M, Gonidakis F, Tziouvas K, Papezova H, Yilmaz Z, Wagner G, Cohen-Woods S, Herms S, Julià A, Rabionet R, Dick DM, Ripatti S, Andreassen OA, Espeseth T, Lundervold AJ, Steen VM, Pinto D, Scherer SW, Aschauer H, Schosser A, Alfredsson L, Padyukov L, Halmi KA, Mitchell J, Strober M, Bergen AW, Kaye W, Szatkiewicz JP, Cormand B, Ramos-Quiroga JA, Sánchez-Mora C, Ribasés M, Casas M, Hervas A, Arranz MJ, Haavik J, Zayats T, Johansson S, Williams N, Dempfle A, Rothenberger A, Kuntsi J, Oades RD, Banaschewski T, Franke B, Buitelaar JK, Arias Vasquez A, Doyle AE, Reif A, Lesch KP, Freitag C, Rivero O, Palmason H, Romanos M, Langley K, Rietschel M, Witt SH, Dalsgaard S, Børglum AD, Waldman I, Wilmot B, Molly N, Bau CHD, Crosbie J, Schachar R, Loo SK, McGough JJ, Grevet EH, Medland SE, Robinson E, Weiss LA, Bacchelli E, Bailey A, Bal V, Battaglia A, Betancur C, Bolton P, Cantor R, Celestino-Soper P, Dawson G, De Rubeis S, Duque F, Green A, Klauck SM, Leboyer M, Levitt P, Maestrini E, Mane S, De-Luca DM, Parr J, Regan R, Reichenberg A, Sandin S, Vorstman J, Wassink T, Wijsman E, Cook E, Santangelo S, Delorme R, Rogé B, Magalhaes T, Arking D, Schulze TG, Thompson RC, Strohmaier J, Matthews K, Melle I, Morris D, Blackwood D, McIntosh A, Bergen SE, Schalling M, Jamain S, Maaser A, Fischer SB, Reinbold CS, Fullerton JM, Guzman-Parra J, Mayoral F, Schofield PR, Cichon S, Mühleisen TW, Degenhardt F, Schumacher J, Bauer M, Mitchell PB, Gershon ES, Rice J, Potash JB, Zandi PP, Craddock N, Ferrier IN, Alda M, Rouleau GA, Turecki G, Ophoff R, Pato C, Anjorin A, Stahl E, Leber M, Czerski PM, Cruceanu C, Jones IR, Posthuma D, Andlauer TFM, Forstner AJ, Streit F, Baune BT, Air T, Sinnamon G, Wray NR, MacIntyre DJ, Porteous D, Homuth G, Rivera M, Grove J, Middeldorp CM, Hickie I, Pergadia M, Mehta D, Smit JH, Jansen R, de Geus E, Dunn E, Li QS, Nauck M, Schoevers RA, Beekman AT, Knowles JA, Viktorin A, Arnold P, Barr CL, Bedoya-Berrio G, Bienvenu OJ, Brentani H, Burton C, Camarena B, Cappi C, Cath D, Cavallini M, Cusi D, Darrow S, Denys D, Derks EM, Dietrich A, Fernandez T, Figee M, Freimer N, Gerber G, Grados M, Greenberg E, Hanna GL, Hartmann A, Hirschtritt ME, Hoekstra PJ, Huang A, Huyser C, Illmann C, Jenike M, Kuperman S, Leventhal B, Lochner C, Lyon GJ, Macciardi F, Madruga-Garrido M, Malaty IA, Maras A, McGrath L, Miguel EC, Mir P, Nestadt G, Nicolini H, Okun MS, Pakstis A, Paschou P, Piacentini J, Pittenger C, Plessen K, Ramensky V, Ramos EM, Reus V, Richter MA, Riddle MA, Robertson MM, Roessner V, Rosário M, Samuels JF, Sandor P, Stein DJ, Tsetsos F, Van Nieuwerburgh F, Weatherall S, Wendland JR, Wolanczyk T, Worbe Y, Zai G, Goes FS, McLaughlin N, Nestadt PS, Grabe HJ, Depienne C, Konkashbaev A, Lanzagorta N, Valencia-Duarte A, Bramon E, Buccola N, Cahn W, Cairns M, Chong SA, Cohen D, Crespo-Facorro B, Crowley J, Davidson M, DeLisi L, Dinan T, Donohoe G, Drapeau E, Duan J, Haan L, Hougaard D, Karachanak-Yankova S, Khrunin A, Klovins J, Kučinskas V, Lee Chee Keong J, Limborska S, Loughland C, Lönnqvist J, Maher B, Mattheisen M, McDonald C, Murphy KC, Nenadic I, van Os J, Pantelis C, Pato M, Petryshen T, Quested D, Roussos P, Sanders AR, Schall U, Schwab SG, Sim K, So HC, Stögmann E, Subramaniam M, Toncheva D, Waddington J, Walters J, Weiser M, Cheng W, Cloninger R, Curtis D, Gejman PV, Henskens F, Mattingsdal M, Oh SY, Scott R, Webb B, Breen G, Churchhouse C, Bulik CM, Daly M, Dichgans M, Faraone SV, Guerreiro R, Holmans P, Kendler KS, Koeleman B, Mathews CA, Price A, Scharf J, Sklar P, Williams J, Wood NW, Cotsapas C, Palotie A, Smoller JW, Sullivan P, Rosand J, Corvin A, Neale BM, Schott JM, Anney R, Elia J, Grigoroiu-Serbanescu M, Edenberg HJ, Murray R. Science. 2018 Jun 22. PMID: 29930110.
- Neural Correlates of Success and Failure Signals During Neurofeedback Learning.Radua J, Stoica T, Scheinost D, Pittenger C, Hampson M. Neuroscience. 2018 May 15; 2016 Apr 5. PMID: 27063101.
- Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [11C]ABP688 and PET imaging study in depression.Esterlis I, DellaGioia N, Pietrzak RH, Matuskey D, Nabulsi N, Abdallah CG, Yang J, Pittenger C, Sanacora G, Krystal JH, Parsey RV, Carson RE, DeLorenzo C. Mol Psychiatry. 2018 Apr; 2017 Apr 11. PMID: 28397841.
- Differential binding of antibodies in PANDAS patients to cholinergic interneurons in the striatum.Frick LR, Rapanelli M, Jindachomthong K, Grant P, Leckman JF, Swedo S, Williams K, Pittenger C. Brain Behav Immun. 2018 Mar; 2017 Dec 9. PMID: 29233751.
- Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models.Xu J, Hartley BJ, Kurup P, Phillips A, Topol A, Xu M, Ononenyi C, Foscue E, Ho SM, Baguley TD, Carty N, Barros CS, Müller U, Gupta S, Gochman P, Rapoport J, Ellman JA, Pittenger C, Aronow B, Nairn AC, Nestor MW, Lombroso PJ, Brennand KJ. Mol Psychiatry. 2018 Feb; 2016 Oct 18. PMID: 27752082.
- The role of stress in the pathogenesis and maintenance of obsessive-compulsive disorder.Adams TG, Kelmendi B, Brake CA, Gruner P, Badour CL, Pittenger C. Chronic Stress (Thousand Oaks). 2018 Jan-Dec; 2018 Mar 4. PMID: 29527593.
- Genetic susceptibility in obsessive-compulsive disorder.Fernandez TV, Leckman JF, Pittenger C. Handb Clin Neurol. 2018. PMID: 29478613.
- Tourette disorder and other tic disorders.Fernandez TV, State MW, Pittenger C. Handb Clin Neurol. 2018. PMID: 29325623.
- Unbending mind: Individuals with hoarding disorder do not modify decision strategy in response to feedback under risk.Pushkarskaya H, Tolin DF, Henick D, Levy I, Pittenger C. Psychiatry Res. 2018 Jan; 2017 Nov 2. PMID: 29154203.
2017
- Modeling tics in rodents: Conceptual challenges and paths forward.Bortolato M, Pittenger C. J Neurosci Methods. 2017 Dec 1; 2017 Feb 22. PMID: 28237575.
- Value-based decision making under uncertainty in hoarding and obsessive- compulsive disorders.Pushkarskaya H, Tolin D, Ruderman L, Henick D, Kelly JM, Pittenger C, Levy I. Psychiatry Res. 2017 Dec; 2017 Aug 24. PMID: 28864119.
- Risky Business: The Circuits that Impact Stress-Induced Decision-Making.Arnsten AFT, Lee D, Pittenger C. Cell. 2017 Nov 16. PMID: 29149614.
- Targeted Interneuron Depletion in the Dorsal Striatum Produces Autism-like Behavioral Abnormalities in Male but Not Female Mice.Rapanelli M, Frick LR, Xu M, Groman SM, Jindachomthong K, Tamamaki N, Tanahira C, Taylor JR, Pittenger C. Biol Psychiatry. 2017 Aug 1; 2017 Feb 10. PMID: 28347488.
- Randomized, Double-Blind, Placebo-Controlled Trial of N-Acetylcysteine Augmentation for Treatment-Resistant Obsessive-Compulsive Disorder.Costa DLC, Diniz JB, Requena G, Joaquim MA, Pittenger C, Bloch MH, Miguel EC, Shavitt RG. J Clin Psychiatry. 2017 Jul. PMID: 28617566.
- The Role of Interneurons in Autism and Tourette Syndrome.Rapanelli M, Frick LR, Pittenger C. Trends Neurosci. 2017 Jul; 2017 May 31. PMID: 28578790.
- Histamine modulation of the basal ganglia circuitry in the development of pathological grooming.Rapanelli M, Frick L, Bito H, Pittenger C. Proc Natl Acad Sci U S A. 2017 Jun 20; 2017 Jun 5. PMID: 28584117.
- Regulation of Alcohol Extinction and Cue-Induced Reinstatement by Specific Projections among Medial Prefrontal Cortex, Nucleus Accumbens, and Basolateral Amygdala.Keistler CR, Hammarlund E, Barker JM, Bond CW, DiLeone RJ, Pittenger C, Taylor JR. J Neurosci. 2017 Apr 26; 2017 Mar 23. PMID: 28336571.
- Intranasal Ketamine and Cognitive-Behavioral Therapy for Treatment-Refractory Obsessive-Compulsive Disorder.Adams TG, Bloch MH, Pittenger C. J Clin Psychopharmacol. 2017 Apr. PMID: 28121735.
- Cognitive inflexibility in Obsessive-Compulsive Disorder.Gruner P, Pittenger C. Neuroscience. 2017 Mar 14; 2016 Aug 1. PMID: 27491478.
- Histamine H3R receptor activation in the dorsal striatum triggers stereotypies in a mouse model of tic disorders.Rapanelli M, Frick L, Pogorelov V, Ohtsu H, Bito H, Pittenger C. Transl Psychiatry. 2017 Jan 24; 2017 Jan 24. PMID: 28117842.
- Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis.Boedhoe PS, Schmaal L, Abe Y, Ameis SH, Arnold PD, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Bose A, Brem S, Calvo A, Cheng Y, Cho KI, Dallaspezia S, Denys D, Fitzgerald KD, Fouche JP, Giménez M, Gruner P, Hanna GL, Hibar DP, Hoexter MQ, Hu H, Huyser C, Ikari K, Jahanshad N, Kathmann N, Kaufmann C, Koch K, Kwon JS, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minuzzi L, Nakamae T, Nakao T, Narayanaswamy JC, Piras F, Piras F, Pittenger C, Reddy YC, Sato JR, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stevens MC, Szeszko PR, Tolin DF, Venkatasubramanian G, Walitza S, Wang Z, van Wingen GA, Xu J, Xu X, Yun JY, Zhao Q, Thompson PM, Stein DJ, van den Heuvel OA. Am J Psychiatry. 2017 Jan 1; 2016 Sep 9. PMID: 27609241.
- Histidine Decarboxylase Knockout Mice as a Model of the Pathophysiology of Tourette Syndrome and Related Conditions.Pittenger C. Handb Exp Pharmacol. 2017. PMID: 28233179.
2016
- Histamine regulation of microglia: Gene-environment interaction in the regulation of central nervous system inflammation.Frick L, Rapanelli M, Abbasi E, Ohtsu H, Pittenger C. Brain Behav Immun. 2016 Oct; 2016 Jul 2. PMID: 27381299.
- The Histamine H3 Receptor Differentially Modulates Mitogen-activated Protein Kinase (MAPK) and Akt Signaling in Striatonigral and Striatopallidal Neurons.Rapanelli M, Frick LR, Horn KD, Schwarcz RC, Pogorelov V, Nairn AC, Pittenger C. J Biol Chem. 2016 Sep 30; 2016 Aug 10. PMID: 27510032.
- Histamine and histamine receptors in Tourette syndrome and other neuropsychiatric conditions.Rapanelli M, Pittenger C. Neuropharmacology. 2016 Jul; 2015 Aug 14. PMID: 26282120.
- Ablation of fast-spiking interneurons in the dorsal striatum, recapitulating abnormalities seen post-mortem in Tourette syndrome, produces anxiety and elevated grooming.Xu M, Li L, Pittenger C. Neuroscience. 2016 Jun 2; 2016 Mar 8. PMID: 26968763.
- OCD is associated with an altered association between sensorimotor gating and cortical and subcortical 5-HT1b receptor binding.Pittenger C, Adams TG Jr, Gallezot JD, Crowley MJ, Nabulsi N, James Ropchan, Gao H, Kichuk SA, Simpson R, Billingslea E, Hannestad J, Bloch M, Mayes L, Bhagwagar Z, Carson RE. J Affect Disord. 2016 May 15; 2016 Feb 9. PMID: 26919057.
- Early onset of response with selective serotonin reuptake inhibitors in obsessive-compulsive disorder: a meta-analysis.Issari Y, Jakubovski E, Bartley CA, Pittenger C, Bloch MH. J Clin Psychiatry. 2016 May. PMID: 27249090.
- Probing Implicit Learning in Obsessive-Compulsive Disorder: Moderating Role of Medication on the Weather Prediction Task.Kelmendi B, Adams T Jr, Jakubovski E, Hawkins KA, Coric V, Pittenger C. J Obsessive Compuls Relat Disord. 2016 Apr. PMID: 27134820.
- Arbitration between Action Strategies in Obsessive-Compulsive Disorder.Gruner P, Anticevic A, Lee D, Pittenger C. Neuroscientist. 2016 Apr; 2015 Jan 20. PMID: 25605642.
- Toward understanding the heterogeneity in obsessive-compulsive disorder: Evidence from narratives in adult patients.Van Schalkwyk GI, Bhalla IP, Griepp M, Kelmendi B, Davidson L, Pittenger C. Aust N Z J Psychiatry. 2016 Jan; 2015 Apr 8. PMID: 25855685.
- Microglial Dysregulation in OCD, Tourette Syndrome, and PANDAS.Frick L, Pittenger C. J Immunol Res. 2016; 2016 Dec 7. PMID: 28053994.
2015
- Decision-making under uncertainty in obsessive-compulsive disorder.Pushkarskaya H, Tolin D, Ruderman L, Kirshenbaum A, Kelly JM, Pittenger C, Levy I. J Psychiatr Res. 2015 Oct; 2015 Aug 12. PMID: 26343609.
- Glutamatergic agents for OCD and related disorders.Pittenger C. Curr Treat Options Psychiatry. 2015 Sep. PMID: 26301176.
- Riluzole augmentation in treatment-refractory obsessive-compulsive disorder: a pilot randomized placebo-controlled trial.Pittenger C, Bloch MH, Wasylink S, Billingslea E, Simpson R, Jakubovski E, Kelmendi B, Sanacora G, Coric V. J Clin Psychiatry. 2015 Aug. PMID: 26214725.
- Glutamate modulators in the treatment of obsessive-compulsive disorder.Pittenger C. Psychiatr Ann. 2015 Jun. PMID: 26236057.
- Histidine decarboxylase knockout mice, a genetic model of Tourette syndrome, show repetitive grooming after induced fear.Xu M, Li L, Ohtsu H, Pittenger C. Neurosci Lett. 2015 May 19; 2015 Apr 1. PMID: 25841792.
- Corticostriatal interactions in the generation of tic-like behaviors after local striatal disinhibition.Pogorelov V, Xu M, Smith HR, Buchanan GF, Pittenger C. Exp Neurol. 2015 Mar; 2015 Jan 15. PMID: 25597650.
- Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome.Xu M, Kobets A, Du JC, Lennington J, Li L, Banasr M, Duman RS, Vaccarino FM, DiLeone RJ, Pittenger C. Proc Natl Acad Sci U S A. 2015 Jan 20; 2015 Jan 5. PMID: 25561540.
- Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD.Yu D, Mathews CA, Scharf JM, Neale BM, Davis LK, Gamazon ER, Derks EM, Evans P, Edlund CK, Crane J, Fagerness JA, Osiecki L, Gallagher P, Gerber G, Haddad S, Illmann C, McGrath LM, Mayerfeld C, Arepalli S, Barlassina C, Barr CL, Bellodi L, Benarroch F, Berrió GB, Bienvenu OJ, Black DW, Bloch MH, Brentani H, Bruun RD, Budman CL, Camarena B, Campbell DD, Cappi C, Silgado JC, Cavallini MC, Chavira DA, Chouinard S, Cook EH, Cookson MR, Coric V, Cullen B, Cusi D, Delorme R, Denys D, Dion Y, Eapen V, Egberts K, Falkai P, Fernandez T, Fournier E, Garrido H, Geller D, Gilbert DL, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Hardy J, Heiman GA, Hemmings SM, Herrera LD, Hezel DM, Hoekstra PJ, Jankovic J, Kennedy JL, King RA, Konkashbaev AI, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Lupoli S, Macciardi F, Maier W, Manunta P, Marconi M, McCracken JT, Mesa Restrepo SC, Moessner R, Moorjani P, Morgan J, Muller H, Murphy DL, Naarden AL, Nurmi E, Ochoa WC, Ophoff RA, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Rauch SL, Renner T, Reus VI, Richter MA, Riddle MA, Robertson MM, Romero R, Rosário MC, Rosenberg D, Ruhrmann S, Sabatti C, Salvi E, Sampaio AS, Samuels J, Sandor P, Service SK, Sheppard B, Singer HS, Smit JH, Stein DJ, Strengman E, Tischfield JA, Turiel M, Valencia Duarte AV, Vallada H, Veenstra-VanderWeele J, Walitza S, Wang Y, Weale M, Weiss R, Wendland JR, Westenberg HG, Shugart YY, Hounie AG, Miguel EC, Nicolini H, Wagner M, Ruiz-Linares A, Cath DC, McMahon W, Posthuma D, Oostra BA, Nestadt G, Rouleau GA, Purcell S, Jenike MA, Heutink P, Hanna GL, Conti DV, Arnold PD, Freimer NB, Stewart SE, Knowles JA, Cox NJ, Pauls DL. Am J Psychiatry. 2015 Jan; 2014 Oct 31. PMID: 25158072.
- Tourette's syndrome and translational clinical science.Fernandez TV, King RA, Pittenger C. J Am Acad Child Adolesc Psychiatry. 2015 Jan. PMID: 25524784.
2014
- Dysregulated intracellular signaling in the striatum in a pathophysiologically grounded model of Tourette syndrome.Rapanelli M, Frick LR, Pogorelov V, Ota KT, Abbasi E, Ohtsu H, Pittenger C. Eur Neuropsychopharmacol. 2014 Dec; 2014 Nov 4. PMID: 25464894.
- Resting state functional connectivity predicts neurofeedback response.Scheinost D, Stoica T, Wasylink S, Gruner P, Saksa J, Pittenger C, Hampson M. Front Behav Neurosci. 2014; 2014 Sep 24. PMID: 25309375.
- Meta-analysis: hoarding symptoms associated with poor treatment outcome in obsessive-compulsive disorder.Bloch MH, Bartley CA, Zipperer L, Jakubovski E, Landeros-Weisenberger A, Pittenger C, Leckman JF. Mol Psychiatry. 2014 Sep; 2014 Jun 10. PMID: 24912494.
- Pharmacological treatment of obsessive-compulsive disorder.Pittenger C, Bloch MH. Psychiatr Clin North Am. 2014 Sep; 2014 Jul 24. PMID: 25150568.
- Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study.McGrath LM, Yu D, Marshall C, Davis LK, Thiruvahindrapuram B, Li B, Cappi C, Gerber G, Wolf A, Schroeder FA, Osiecki L, O'Dushlaine C, Kirby A, Illmann C, Haddad S, Gallagher P, Fagerness JA, Barr CL, Bellodi L, Benarroch F, Bienvenu OJ, Black DW, Bloch MH, Bruun RD, Budman CL, Camarena B, Cath DC, Cavallini MC, Chouinard S, Coric V, Cullen B, Delorme R, Denys D, Derks EM, Dion Y, Rosário MC, Eapen V, Evans P, Falkai P, Fernandez TV, Garrido H, Geller D, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Heiman GA, Hemmings SM, Herrera LD, Hounie AG, Jankovic J, Kennedy JL, King RA, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Lochner C, Lowe TL, Lyon GJ, Macciardi F, Maier W, McCracken JT, McMahon W, Murphy DL, Naarden AL, Neale BM, Nurmi E, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Reus VI, Richter MA, Riddle M, Robertson MM, Rosenberg D, Rouleau GA, Ruhrmann S, Sampaio AS, Samuels J, Sandor P, Sheppard B, Singer HS, Smit JH, Stein DJ, Tischfield JA, Vallada H, Veenstra-VanderWeele J, Walitza S, Wang Y, Wendland JR, Shugart YY, Miguel EC, Nicolini H, Oostra BA, Moessner R, Wagner M, Ruiz-Linares A, Heutink P, Nestadt G, Freimer N, Petryshen T, Posthuma D, Jenike MA, Cox NJ, Hanna GL, Brentani H, Scherer SW, Arnold PD, Stewart SE, Mathews CA, Knowles JA, Cook EH, Pauls DL, Wang K, Scharf JM. J Am Acad Child Adolesc Psychiatry. 2014 Aug; 2014 Jun 24. PMID: 25062598.
- Altered global brain signal in schizophrenia.Yang GJ, Murray JD, Repovs G, Cole MW, Savic A, Glasser MF, Pittenger C, Krystal JH, Wang XJ, Pearlson GD, Glahn DC, Anticevic A. Proc Natl Acad Sci U S A. 2014 May 20; 2014 May 5. PMID: 24799682.
- Global resting-state functional magnetic resonance imaging analysis identifies frontal cortex, striatal, and cerebellar dysconnectivity in obsessive-compulsive disorder.Anticevic A, Hu S, Zhang S, Savic A, Billingslea E, Wasylink S, Repovs G, Cole MW, Bednarski S, Krystal JH, Bloch MH, Li CS, Pittenger C. Biol Psychiatry. 2014 Apr 15; 2013 Nov 4. PMID: 24314349.
- Lesions of the dorsomedial striatum delay spatial learning and render cue-based navigation inflexible in a water maze task in mice.Lee AS, André JM, Pittenger C. Front Behav Neurosci. 2014; 2014 Feb 13. PMID: 24592223.
- Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice.Baldan LC, Williams KA, Gallezot JD, Pogorelov V, Rapanelli M, Crowley M, Anderson GM, Loring E, Gorczyca R, Billingslea E, Wasylink S, Panza KE, Ercan-Sencicek AG, Krusong K, Leventhal BL, Ohtsu H, Bloch MH, Hughes ZA, Krystal JH, Mayes L, de Araujo I, Ding YS, State MW, Pittenger C. Neuron. 2014 Jan 8. PMID: 24411733.
2013
- Disorders of memory and plasticity in psychiatric disease.Pittenger C. Dialogues Clin Neurosci. 2013 Dec. PMID: 24459412.
- Long-term outcome in adults with obsessive-compulsive disorder.Bloch MH, Green C, Kichuk SA, Dombrowski PA, Wasylink S, Billingslea E, Landeros-Weisenberger A, Kelmendi B, Goodman WK, Leckman JF, Coric V, Pittenger C. Depress Anxiety. 2013 Aug; 2013 Mar 26. PMID: 23532944.
- Two cases of delayed-onset suicidal ideation, dysphoria and anxiety after ketamine infusion in patients with obsessive-compulsive disorder and a history of major depressive disorder.Niciu MJ, Grunschel BD, Corlett PR, Pittenger C, Bloch MH. J Psychopharmacol. 2013 Jul; 2013 May 15. PMID: 23676198.
- Symptom dimensions are associated with age of onset and clinical course of obsessive-compulsive disorder.Kichuk SA, Torres AR, Fontenelle LF, Rosário MC, Shavitt RG, Miguel EC, Pittenger C, Bloch MH. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jul 1; 2013 Feb 12. PMID: 23410525.
- Orbitofrontal cortex neurofeedback produces lasting changes in contamination anxiety and resting-state connectivity.Scheinost D, Stoica T, Saksa J, Papademetris X, Constable RT, Pittenger C, Hampson M. Transl Psychiatry. 2013 Apr 30; 2013 Apr 30. PMID: 23632454.
- Age and gender correlates of pulling in pediatric trichotillomania.Panza KE, Pittenger C, Bloch MH. J Am Acad Child Adolesc Psychiatry. 2013 Mar. PMID: 23452681.
- N-Acetylcysteine in the treatment of pediatric trichotillomania: a randomized, double-blind, placebo-controlled add-on trial.Bloch MH, Panza KE, Grant JE, Pittenger C, Leckman JF. J Am Acad Child Adolesc Psychiatry. 2013 Mar. PMID: 23452680.
- Microglial dysregulation in psychiatric disease.Frick LR, Williams K, Pittenger C. Clin Dev Immunol. 2013; 2013 Apr 18. PMID: 23690824.
2012
- Effects of ketamine in treatment-refractory obsessive-compulsive disorder.Bloch MH, Wasylink S, Landeros-Weisenberger A, Panza KE, Billingslea E, Leckman JF, Krystal JH, Bhagwagar Z, Sanacora G, Pittenger C. Biol Psychiatry. 2012 Dec 1; 2012 Jul 10. PMID: 22784486.
- The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications.Carty NC, Xu J, Kurup P, Brouillette J, Goebel-Goody SM, Austin DR, Yuan P, Chen G, Correa PR, Haroutunian V, Pittenger C, Lombroso PJ. Transl Psychiatry. 2012 Jul 10; 2012 Jul 10. PMID: 22781170.
- Real-time fMRI biofeedback targeting the orbitofrontal cortex for contamination anxiety.Hampson M, Stoica T, Saksa J, Scheinost D, Qiu M, Bhawnani J, Pittenger C, Papademetris X, Constable T. J Vis Exp. 2012 Jan 20; 2012 Jan 20. PMID: 22297729.
2011
- Pathophysiological modeling of obsessive-compulsive disorder: challenges, and progress.Pittenger C. Biol Psychiatry. 2011 Dec 1. PMID: 22045035.
- Glutamate abnormalities in obsessive compulsive disorder: neurobiology, pathophysiology, and treatment.Pittenger C, Bloch MH, Williams K. Pharmacol Ther. 2011 Dec; 2011 Sep 22. PMID: 21963369.
- Association of polymorphisms in HCN4 with mood disorders and obsessive compulsive disorder.Kelmendi B, Holsbach-Beltrame M, McIntosh AM, Hilt L, George ED, Kitchen RR, Carlyle BC, Pittenger C, Coric V, Nolen-Hoeksema S, Sanacora G, Simen AA. Neurosci Lett. 2011 Jun 8; 2011 Apr 20. PMID: 21529705.
- Epigenetic modification of the BDNF locus by early-life enrichment: towards a molecular correlate of resilience?Pittenger C. Neurosci Lett. 2011 May 20; 2011 Mar 22. PMID: 21435373.
- High levels of histidine decarboxylase in the striatum of mice and rats.Krusong K, Ercan-Sencicek AG, Xu M, Ohtsu H, Anderson GM, State MW, Pittenger C. Neurosci Lett. 2011 May 16; 2011 Apr 1. PMID: 21440039.
- Lesions of the dorsomedial striatum disrupt prepulse inhibition.Baldan Ramsey LC, Xu M, Wood N, Pittenger C. Neuroscience. 2011 Apr 28; 2011 Feb 15. PMID: 21315809.
- Recent advances in Tourette syndrome.Bloch M, State M, Pittenger C. Curr Opin Neurol. 2011 Apr. PMID: 21386676.
2010
- Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model.Zhang Y, Kurup P, Xu J, Carty N, Fernandez SM, Nygaard HB, Pittenger C, Greengard P, Strittmatter SM, Nairn AC, Lombroso PJ. Proc Natl Acad Sci U S A. 2010 Nov 2; 2010 Oct 18. PMID: 20956308.
- Dissociable regulation of instrumental action within mouse prefrontal cortex.Gourley SL, Lee AS, Howell JL, Pittenger C, Taylor JR. Eur J Neurosci. 2010 Nov; 2010 Oct 12. PMID: 21044173.
- Cued and spatial learning in the water maze: equivalent learning in male and female mice.Baldan Ramsey LC, Pittenger C. Neurosci Lett. 2010 Oct 11; 2010 Aug 5. PMID: 20691760.
- Meta-analysis of the dose-response relationship of SSRI in obsessive-compulsive disorder.Bloch MH, McGuire J, Landeros-Weisenberger A, Leckman JF, Pittenger C. Mol Psychiatry. 2010 Aug; 2009 May 26. PMID: 19468281.
- The Genetics of Obsessive-Compulsive Disorder.Bloch MH, Pittenger C. Curr Psychiatry Rev. 2010 May 1. PMID: 23970845.