Glutamate uptake by oligodendrocytes
Pitt D, Nagelmeier IE, Wilson HC, Raine CS. Glutamate uptake by oligodendrocytes. Neurology 2003, 61: 1113-1120. PMID: 14581674, DOI: 10.1212/01.wnl.0000090564.88719.37.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAstrocytesAutoradiographyBiological TransportCell SurvivalCells, CulturedDose-Response Relationship, DrugExcitatory Amino Acid Transporter 1Excitatory Amino Acid Transporter 2FemaleGene ExpressionGlutamic AcidHumansIn Situ HybridizationMaleMiddle AgedMultiple SclerosisNeurotoxinsOligodendrogliaRNA, MessengerSpinal CordTritiumTumor Necrosis Factor-alphaConceptsMS white matterEAAT-2EAAT-1White matterExtracellular glutamateGlutamate uptakePredominant cellsHuman oligodendrocytesGlutamate removalProinflammatory cytokine tumor necrosisHuman white matterNormal human white matterCommon pathologic eventGlutamate transporter expressionGlutamate receptor expressionCytokine tumor necrosisExcess extracellular glutamateInhibited glutamate uptakeHigh extracellular glutamateSubsequent overstimulationExcitotoxic damageGlutamate excitotoxicityGlutamate clearanceTumor necrosisReceptor expressionExperimental Autoimmune Encephalomyelitis (EAE) in CCR2−/− Mice Susceptibility in Multiple Strains
Gaupp S, Pitt D, Kuziel WA, Cannella B, Raine CS. Experimental Autoimmune Encephalomyelitis (EAE) in CCR2−/− Mice Susceptibility in Multiple Strains. American Journal Of Pathology 2003, 162: 139-150. PMID: 12507897, PMCID: PMC1851120, DOI: 10.1016/s0002-9440(10)63805-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DivisionCrosses, GeneticDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalGenetic Predisposition to DiseaseGlycoproteinsImmunity, InnateImmunohistochemistryIn Situ HybridizationLymphocytesMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred StrainsMice, KnockoutMyelin SheathMyelin-Oligodendrocyte GlycoproteinNuclease Protection AssaysPeptide FragmentsReceptors, CCR2Receptors, ChemokineRNA, MessengerSpecies SpecificityConceptsExperimental autoimmune encephalomyelitisCentral nervous systemAutoimmune encephalomyelitisLow molecular weight cytokinesLack of CCR2Deletion of CCR2Sites of inflammationWild-type animalsDifferent mouse strainsCCR2 deletionCNS lesionsMultiple sclerosisWeight cytokinesAutoimmune diseasesMouse susceptibilityNervous systemImmune systemCompensatory mechanismsBalb CCCR2Mouse strainsChemokinesMonocytesEncephalomyelitisAppropriate receptors