Concise Review: Modeling Multiple Sclerosis With Stem Cell Biological Platforms: Toward Functional Validation of Cellular and Molecular Phenotypes in Inflammation-Induced Neurodegeneration
Orack JC, Deleidi M, Pitt D, Mahajan K, Nicholas JA, Boster AL, Racke MK, Comabella M, Watanabe F, Imitola J. Concise Review: Modeling Multiple Sclerosis With Stem Cell Biological Platforms: Toward Functional Validation of Cellular and Molecular Phenotypes in Inflammation-Induced Neurodegeneration. Stem Cells Translational Medicine 2015, 4: 252-260. PMID: 25593207, PMCID: PMC4339849, DOI: 10.5966/sctm.2014-0133.Peer-Reviewed Original ResearchConceptsSomatic cell reprogrammingStem cellsInduced pluripotent stem cell (iPSC) technologyPluripotent stem cell (iPSC) technologyOligodendrocyte progenitor cellsMultiple sclerosisGeneration of neuronsNew mechanistic insightsCell reprogrammingNovel stem cellFunctional validationStem cell technologyMolecular mechanismsBiological toolsMesenchymal stem cellsMolecular phenotypesNovel mechanismProgenitor cellsImmune cell functionPhase I clinical trialMechanistic insightsBiological platformCell functionSignificant unmet needBrain atrophy