Sunil Parikh, MD, MPH
Professor of Epidemiology (Microbial Diseases) and of Infectious DiseasesCards
Appointments
Additional Titles
Co-Chair Downs Fellowship, Epidemiology of Microbial Diseases
Contact Info
Epidemiology of Microbial Diseases
60 College Street, P.O. Box 208322
New Haven, CA 06520
United States
Appointments
Additional Titles
Co-Chair Downs Fellowship, Epidemiology of Microbial Diseases
Contact Info
Epidemiology of Microbial Diseases
60 College Street, P.O. Box 208322
New Haven, CA 06520
United States
Appointments
Additional Titles
Co-Chair Downs Fellowship, Epidemiology of Microbial Diseases
Contact Info
Epidemiology of Microbial Diseases
60 College Street, P.O. Box 208322
New Haven, CA 06520
United States
About
Titles
Professor of Epidemiology (Microbial Diseases) and of Infectious Diseases
Co-Chair Downs Fellowship, Epidemiology of Microbial Diseases
Biography
Professor Parikh’s research interests focus on translational studies of malaria in sub-Saharan Africa. Dr. Parikh focuses upon several aspects of malaria in sub-Saharan Africa, including studies on optimizing treatment regimens, novel chemoprevention strategies, drug resistance emergence and spread, and parasite dynamics. Current projects include: (1) understanding parasite, drug, and host factors affecting response to artemisinin-based antimalarial therapies using a combination of individual and population-based approaches to inform treatment guidelines (Uganda and Burkina Faso); 2) cluster-randomized trial of endectocides to reduce malaria transmission (Burkina Faso); and 3) characterizing the epidemiology of antimalarial drug resistance and non-falciparum species in sub-Saharan Africa (Cameroon and Burkina Faso), 4) testing of a novel noninvasive diagnostic device for malaria (Cameroon). Dr. Parikh has ongoing projects in several African countries, which utilize observational and cross-sectional designs, as well as prospective clinical trials. Recently, the Parikh lab, in collaboration with colleagues at Colorado State University (Prof Foy), and IRSSINSTech in Burkina Faso (Prof. Dabire and Ouedraogo) were awarded an International Center of Excellence in Malaria Research. Dr. Parikh received his M.D. degree from Johns Hopkins University School of Medicine and completed his medical residency training at the Beth Israel Deaconess Medical Center. After completing his fellowship in Infectious Diseases at the University of California, San Francisco and Masters in Public Health at UC Berkeley he joined the faculty at UCSF. He has been a member of the Department of Epidemiology of Microbial Diseases in the Yale School of Public Health and Section of Infectious Diseases in the Yale School of Medicine since 2012.
Appointments
Epidemiology of Microbial Diseases
ProfessorPrimaryInfectious Diseases
ProfessorSecondary
Other Departments & Organizations
- African Studies
- Center for Interdisciplinary Research on AIDS
- Epidemiology of Microbial Diseases
- Infectious Diseases
- Internal Medicine
- Parikh Lab
- Yale Institute for Global Health
- Yale School of Public Health
- Yale School of Public Health - NEW
- Yale Ventures
- Yale-UPR Integrated HIV Basic and Clinical Sciences Initiative
- YSPH Global Health Concentration
Education & Training
- MPH
- University of California at Berkeley (2005)
- Fellow
- University of California - San Francisco (2004)
- Resident
- Beth Israel Deaconess Medical Center - Boston (2001)
- MD
- Johns Hopkins University School of Medicine (1998)
Research
Overview
1) Antimalarial therapy/efficacy studies in children and those with HIV/malaria co-infection in Uganda
Major Goal: To assess the pharmacokinetics and pharmacodynamics of artemisinin-combination therapies, toxicity of newer antiretrovirals (dolutegravir), and determinants of artemisinin partial drug resistance in two different settings in Uganda.
2) Use of novel approaches to preventing malaria in Burkina Faso
Major Goal: We are conducting a cluster-randomized trial of a novel chemopreventive approach in Burkina Faso
3) Characterizing the epidemiology of malaria species across three different transmission zones in Burkina Faso through longitudinal human cohorts coupled with spatial mapping and mosquito studies (Burkina Faso ICEMR - "PIVOTAL")
4) Development and diagnostic performance studies of a non-invasive diagnostic device for malaria in Cameroon and Burkina Faso.
Medical Research Interests
Public Health Interests
- View Lab Website
Parikh Lab
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Martina Wade
Justin Goodwin
Fangyong Li, MS, MPH
Amy Bei, PhD
Jean Bosco Ouedraogo
Jillian Armstrong
Publications
2024
Two mosquito salivary antigens demonstrate promise as biomarkers of recent exposure to P. falciparum infected mosquito bites
Lapidus S, Goheen M, Sy M, Deme A, Ndiaye I, Diedhiou Y, Mbaye A, Hagadorn K, Sene S, Pouye M, Thiam L, Ba A, Guerra N, Mbengue A, Raduwan H, Gagnon J, Vigan-Womas I, Parikh S, Ko A, Ndiaye D, Fikrig E, Chuang Y, Bei A. Two mosquito salivary antigens demonstrate promise as biomarkers of recent exposure to P. falciparum infected mosquito bites. The Journal Of Infectious Diseases 2024, jiae525. PMID: 39475423, DOI: 10.1093/infdis/jiae525.Peer-Reviewed Original ResearchConceptsModerate transmission areasMosquito salivary proteinsModerately endemic areaAntibody responseMosquito exposureTransmission seasonP. falciparum infectionMalaria transmission seasonMalaria transmission intensityExposure to infectious mosquitoesMosquito bitesEntomological inoculation rateEndemic areasHuman immune responseInfected mosquito bitesTransmission areasDecline 3 monthsNo antibody responseExposure to infected mosquitoesP. falciparumControl cohortExposure to mosquitoesBead-based assayImmune responseSalivary proteinsNoninvasive in vivo photoacoustic detection of malaria with Cytophone in Cameroon
Yadem A, Armstrong J, Sarimollaoglu M, Kiki Massa C, Ndifo J, Menyaev Y, Mbe A, Richards K, Wade M, Zeng Y, Chen R, Zhou Q, Meten E, Ntone R, Tchuedji Y, Ullah S, Galanzha E, Eteki L, Gonsu H, Biris A, Suen J, Boum Y, Zharov V, Parikh S. Noninvasive in vivo photoacoustic detection of malaria with Cytophone in Cameroon. Nature Communications 2024, 15: 9228. PMID: 39455558, PMCID: PMC11511992, DOI: 10.1038/s41467-024-53243-z.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsClearance of parasitemiaDetection of malariaMalaria-infected red blood cellsDiagnosed symptomatic casesCross-sectional cohortUncomplicated malariaMalaria diagnosticsMalaria infectionRed blood cellsSymptomatic casesTarget antigenAsymptomatic reservoirCameroonian adultsFlow cytometer platformBlood samplesReservoir of infectionBlood cellsLack sensitivityLongitudinal cohortMolecular assaysMalariaIRBCPoint-of-careCohortQuantitative PCRPersistent and multiclonal malaria parasite dynamics despite extended artemether-lumefantrine treatment in children
Goodwin J, Kajubi R, Wang K, Li F, Wade M, Orukan F, Huang L, Whalen M, Aweeka F, Mwebaza N, Parikh S. Persistent and multiclonal malaria parasite dynamics despite extended artemether-lumefantrine treatment in children. Nature Communications 2024, 15: 3817. PMID: 38714692, PMCID: PMC11076639, DOI: 10.1038/s41467-024-48210-7.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsDay 7 lumefantrine concentrationsArtemether-lumefantrine treatmentRing-stage parasitesEarly post-treatmentEarly post-treatment periodArtemether-lumefantrineArtemisinin resistanceDay regimenMulticlonal infectionsEfficacious therapyFollow-upRandomized trialsPersistent clonesTransmission settingsEffective treatmentPost-treatment periodRegimensAntimalarial studiesStandard diagnosticsStandard 3DaysPost-treatmentChildrenTreatmentTherapy
2023
Lessons Learned from the Connecticut Response to COVID-19 in Nursing Homes during the First 2 Years of the Pandemic
Goodwin J, Harizaj A, Armstrong J, Maloney M, Ehrlich H, Leung V, Parikh S. Lessons Learned from the Connecticut Response to COVID-19 in Nursing Homes during the First 2 Years of the Pandemic. Journal Of The American Medical Directors Association 2023, 24: 1573-1578.e1. PMID: 37591486, DOI: 10.1016/j.jamda.2023.07.009.Peer-Reviewed Original ResearchAltmetricConceptsNursing homesSARS-CoV-2-related deathLong-term care facilitiesNursing home residentsPublic healthConnecticut nursing homesPublic health crisisCOVID-19 casesHome residentsCOVID-19 surveillance systemCare facilitiesDeath burdenEarly pandemicLong-term care industryPandemic threatCOVID-19Connecticut DepartmentHealth crisisSurveillance systemInterventionPandemicHealthConnecticut populationHomeVaccineTracking antimalarial drug resistance using mosquito blood meals: a cross-sectional study
Ehrlich H, Somé A, Bazié T, Ebou C, Dembélé E, Balma R, Goodwin J, Wade M, Bei A, Ouédraogo J, Foy B, Dabiré R, Parikh S. Tracking antimalarial drug resistance using mosquito blood meals: a cross-sectional study. The Lancet Microbe 2023, 4: e461-e469. PMID: 37086737, PMCID: PMC10365133, DOI: 10.1016/s2666-5247(23)00063-0.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMosquito blood mealsAntimalarial drug resistanceSurvey 3Blood-fed mosquitoesBlood samplesSurvey 1Survey 2Blood mealDrug resistanceUltrasensitive quantitative PCRHuman blood samplesCross-sectional studyMargin of equivalenceStrong surveillance systemCross-sectional surveySupplementary Materials sectionMarker of clonalityPragmatic thresholdAntimalarial resistanceDrug susceptibilityInfectious diseasesPlasmodium falciparumNational InstituteTolerabilityMaterial sectionRepeat Ivermectin Mass Drug Administrations for Malaria Control II: Protocol for a Double-blind, Cluster-Randomized, Placebo-Controlled Trial for the Integrated Control of Malaria
Foy B, Some A, Magalhaes T, Gray L, Rao S, Sougue E, Jackson C, Kittelson J, Slater H, Bousema T, Da O, Coulidiaty A, Colt M, Wade M, Richards K, Some A, Dabire R, Parikh S. Repeat Ivermectin Mass Drug Administrations for Malaria Control II: Protocol for a Double-blind, Cluster-Randomized, Placebo-Controlled Trial for the Integrated Control of Malaria. JMIR Research Protocols 2023, 12: e41197. PMID: 36939832, PMCID: PMC10132043, DOI: 10.2196/41197.Peer-Reviewed Original ResearchCitationsAltmetricConceptsIvermectin mass drug administrationMass drug administrationINTERNATIONAL REGISTERED REPORT IDENTIFIERMalaria incidenceDrug AdministrationMalaria transmissionIntense seasonal malaria transmissionMalaria controlSecondary safety outcomesParallel-group trialSeasonal malaria transmissionAdverse event monitoringActive case surveillancePrimary outcomeControl IINonpregnant individualsPostintervention changesTrial interventionCare interventionsSafety outcomesCluster RandomizedSubset of individualsCase surveillanceConsecutive daysEntomological assessmentsArtemether-lumefantrine efficacy among adults on antiretroviral therapy in Malawi
Nyangulu W, Mungwira R, Divala T, Nampota-Nkomba N, Nyirenda O, Buchwald A, Miller J, Earland D, Adams M, Plowe C, Taylor T, Mallewa J, van Oosterhout J, Parikh S, Laurens M, Laufer M. Artemether-lumefantrine efficacy among adults on antiretroviral therapy in Malawi. Malaria Journal 2023, 22: 32. PMID: 36707795, PMCID: PMC9881508, DOI: 10.1186/s12936-023-04466-w.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsAntiretroviral therapyLumefantrine levelsTreatment failureDrug-drug interactionsACPR ratesMalaria infectionTrimethoprim-sulfamethoxazolePCR correctionTreatment efficacyUndetectable HIV RNA viral loadEfavirenz-based antiretroviral therapyHIV RNA viral loadUncomplicated Plasmodium falciparum malariaHuman immunodeficiency virus (HIV) infectionArtemether-lumefantrine efficacyCohort of PWHEfavirenz-based regimensImmunodeficiency virus infectionRNA viral loadPlasmodium falciparum malariaMalaria treatment failurePopulation of adultsRandom-effects modelTherapeutic efficacy monitoringLumefantrine exposureStriving towards true equity in global health: A checklist for bilateral research partnerships
Hodson D, Etoundi Y, Parikh S, Boum Y. Striving towards true equity in global health: A checklist for bilateral research partnerships. PLOS Global Public Health 2023, 3: e0001418. PMID: 36963065, PMCID: PMC10021183, DOI: 10.1371/journal.pgph.0001418.Peer-Reviewed Original ResearchCitationsAltmetricConceptsHigh-income countriesGlobal health scholarshipTeam membersHealth scholarshipLMIC institutionsGlobal health collaborationsGlobal healthMiddle-income countriesGlobal health researchGlobal health projectsGlobal health effortsLevel of trainingHealth collaborationHealth disciplinesGlobal health organizationsHealth effortsHealth researchHealth ProjectImprove equitySchool of MedicineGlobal health issueLMICsHealth issuesResearch partnershipsEquitable collaboration
2022
Moving towards malaria elimination with safer treatment for children with G6PD deficiency
Boum Y, Moukoko C, Parikh S. Moving towards malaria elimination with safer treatment for children with G6PD deficiency. The Lancet Infectious Diseases 2022, 23: 388-390. PMID: 36462525, DOI: 10.1016/s1473-3099(22)00724-1.Peer-Reviewed Original ResearchCitationsAltmetricImpact of Drug Exposure on Resistance Selection Following Artemether‐Lumefantrine Treatment for Malaria in Children With and Without HIV in Uganda
Kay K, Goodwin J, Ehrlich H, Ou J, Freeman T, Wang K, Li F, Wade M, French J, Huang L, Aweeka F, Mwebaza N, Kajubi R, Riggs M, Ruiz‐Garcia A, Parikh S. Impact of Drug Exposure on Resistance Selection Following Artemether‐Lumefantrine Treatment for Malaria in Children With and Without HIV in Uganda. Clinical Pharmacology & Therapeutics 2022, 113: 660-669. PMID: 36260349, PMCID: PMC9981240, DOI: 10.1002/cpt.2768.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLopinavir-ritonavirLumefantrine concentrationsSensitive parasitesRecurrence riskPopulation PK/PD modelArtemether-lumefantrine treatmentTrimethoprim-sulfamethoxazole prophylaxisPK/PD modelPopulation PK modelFirst-order absorptionHigh transmission regionsAntiretroviral regimensLumefantrine exposureLumefantrine susceptibilityPfcrt K76Pfmdr1 N86Suboptimal dosingArtemether-lumefantrineTwo-compartment modelHIV statusRecurrent infectionsCombination therapyDrug exposurePrimary treatmentArtemisinin resistance
Academic Achievements & Community Involvement
activity COVID-19 in Connecticut Long-term Care Facilities
ResearchDetails04/01/2020 - PresentNew Haven, CT, United StatesAbstract/SynopsisContract with DPH to assist in surveillance and infection prevention and control of COVID-19 in long-term care facilities
activity Integration of HIV, TB, and malaria
ResearchDetails04/01/2019 - PresentPort-au-Prince, Ouest Department, Haitiactivity Malaria research in Cameroon
ResearchDetails09/01/2017 - PresentYaounde, Centre, CameroonCollaborators- Yap Boum IIMSF Epicentre
Abstract/SynopsisNovel non-invasive diagnosis of malaria
honor Hecht-Albert Pilot Innovation Award for Junior Faculty
Yale University AwardGlobal Health Leadership InstituteDetails05/02/2016United Statesactivity Alliance for Stroke Awareness and Prevention Project
VolunteerActivityDetails01/01/2011 - PresentNew Delhi, NCT, India; Kampala, Central Region, UgandaAbstract/SynopsisBoard Member, Non-profit working in Uganda and India on projects related to stroke prevention, such as hypertension screening.
Teaching & Mentoring
Teaching
Didactic EMD 567: Tackling the Big Three: Malaria, TB, and HIV in Resource-Limited Settings
LecturerLecture SettingDetails9/1/2014 - PresentForGraduate30 Average Instructional Hours Per YearMalaria, tuberculosis, and HIV account for more than five million deaths worldwide each year. This course provides a deep foundation for understanding these pathogens and explores the public health issues that surround these infectious diseases in resource-limited settings. Emphasis is placed on issues in Africa, but contrasts for each disease are provided in the broader developing world. The course is divided into three sections, each focusing in depth on the individual infectious disease as well as discussions of interactions among the three diseases. The sections consist of three to four lectures each on the biology, individual consequences, and community/public health impact of each infectious disease. Discussion of ongoing, field-based research projects involving the diseases is led by relevant faculty (research into practice). The course culminates with a critical discussion of major public health programmatic efforts to tackle these diseases, such as those of PEPFAR, the Bill & Melinda Gates Foundation, the Global Fund, and the Stop TB Partnership.
News & Links
News
- November 27, 2024Source: Advanced Science News
New malaria test “listens” to cells to make diagnosis
- November 18, 2024Source: Malaria No More
ASTMH Annual Meeting: Experts Address Malaria Challenges & Solutions
- November 12, 2024Source: Malaria Research Institute
The Skin-Contact Malaria Test That Could Revolutionize Diagnostics
- November 12, 2024Source: Physics World
From melanoma to malaria: photoacoustic device detects disease without taking a single drop of blood
Get In Touch
Contacts
Epidemiology of Microbial Diseases
60 College Street, P.O. Box 208322
New Haven, CA 06520
United States
Administrative Support
Locations
60 College Street
Lab
Ste 7th floor
New Haven, CT 06510
60 College Street
Academic Office
Ste 724
New Haven, CT 06510