HRP2 and pLDH-Based Rapid Diagnostic Tests, Expert Microscopy, and PCR for Detection of Malaria Infection during Pregnancy and at Delivery in Areas of Varied Transmission: A Prospective Cohort Study in Burkina Faso and Uganda
Kyabayinze D, Zongo I, Cunningham J, Gatton M, Angutoko P, Ategeka J, Compaoré Y, Muehlenbachs A, Mulondo J, Nakalembe M, Somé F, Ouattara A, Rouamba N, Ouédraogo J, Hopkins H, Bell D. HRP2 and pLDH-Based Rapid Diagnostic Tests, Expert Microscopy, and PCR for Detection of Malaria Infection during Pregnancy and at Delivery in Areas of Varied Transmission: A Prospective Cohort Study in Burkina Faso and Uganda. PLOS ONE 2016, 11: e0156954. PMID: 27380525, PMCID: PMC4933335, DOI: 10.1371/journal.pone.0156954.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntigens, ProtozoanBurkina FasoDiagnostic Tests, RoutineFemaleFollow-Up StudiesHost-Parasite InteractionsHumansInfant, NewbornL-Lactate DehydrogenaseMalaria, FalciparumMicroscopyPlasmodium falciparumPoint-of-Care SystemsPolymerase Chain ReactionPregnancyPregnancy Trimester, SecondPregnancy Trimester, ThirdPrenatal CareProspective StudiesProtozoan ProteinsReproducibility of ResultsSeasonsSensitivity and SpecificityUgandaYoung AdultConceptsPLDH rapid diagnostic testsRapid diagnostic testsHistidine-rich protein 2Screening testMulti-center prospective studyDiagnostic testsDifferent malaria transmission settingsTororo District HospitalIntermittent preventive treatmentProspective cohort studyLow-density infectionsPCR-positive womenMalaria transmission settingsAppropriate screening testsTest positivity rateTreatment of malariaAntenatal visitsCohort studySymptomatic womenExpert microscopyThird trimesterIntermittent screeningPregnant womenProspective studyMalaria infectionEvaluation of the Antiplasmodial Activity and Lethality of the Leaf Extract of <I>Cassia alata</I> L. (Fabaceae)
Da O, Yerbanga R, Traore/Coulibaly M, Koama B, Kabre Z, Tamboura S, Dakuyo Z, Sekhoacha M, Matsabisa M, Nikiema J, Ouedraogo J, Ouedraogo G. Evaluation of the Antiplasmodial Activity and Lethality of the Leaf Extract of Cassia alata L. (Fabaceae). Pakistan Journal Of Biological Sciences 2016, 19: 171-178. PMID: 29022993, DOI: 10.3923/pjbs.2016.171.178.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntimalarialsCassiaDisease Models, AnimalFemaleLethal Dose 50L-Lactate DehydrogenaseMalaria, FalciparumMaleMaximum Tolerated DoseMethanolMethylene ChlorideMiceParasitic Sensitivity TestsPhytotherapyPlant ExtractsPlant LeavesPlants, MedicinalPlasmodium falciparumProtozoan ProteinsSolventsConceptsVivo antiplasmodial activityBody weightAntiplasmodial activityPlasmodium falciparumMean percent suppressionDay suppressive testChloroquine-sensitive strainNon-lethal doseParasite lactate dehydrogenase assayAnimal body weightMaximum non-lethal doseMethanol leaf extractSuppressive testSignificant changesLactate dehydrogenase assayOral routePercent suppressionHematological parametersHigh dosesHaematological parametersPlasmodium bergheiMiceAntimalarial potentialLeaf extractCassia alata