2016
HRP2 and pLDH-Based Rapid Diagnostic Tests, Expert Microscopy, and PCR for Detection of Malaria Infection during Pregnancy and at Delivery in Areas of Varied Transmission: A Prospective Cohort Study in Burkina Faso and Uganda
Kyabayinze D, Zongo I, Cunningham J, Gatton M, Angutoko P, Ategeka J, Compaoré Y, Muehlenbachs A, Mulondo J, Nakalembe M, Somé F, Ouattara A, Rouamba N, Ouédraogo J, Hopkins H, Bell D. HRP2 and pLDH-Based Rapid Diagnostic Tests, Expert Microscopy, and PCR for Detection of Malaria Infection during Pregnancy and at Delivery in Areas of Varied Transmission: A Prospective Cohort Study in Burkina Faso and Uganda. PLOS ONE 2016, 11: e0156954. PMID: 27380525, PMCID: PMC4933335, DOI: 10.1371/journal.pone.0156954.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntigens, ProtozoanBurkina FasoDiagnostic Tests, RoutineFemaleFollow-Up StudiesHost-Parasite InteractionsHumansInfant, NewbornL-Lactate DehydrogenaseMalaria, FalciparumMicroscopyPlasmodium falciparumPoint-of-Care SystemsPolymerase Chain ReactionPregnancyPregnancy Trimester, SecondPregnancy Trimester, ThirdPrenatal CareProspective StudiesProtozoan ProteinsReproducibility of ResultsSeasonsSensitivity and SpecificityUgandaYoung AdultConceptsPLDH rapid diagnostic testsRapid diagnostic testsHistidine-rich protein 2Screening testMulti-center prospective studyDiagnostic testsDifferent malaria transmission settingsTororo District HospitalIntermittent preventive treatmentProspective cohort studyLow-density infectionsPCR-positive womenMalaria transmission settingsAppropriate screening testsTest positivity rateTreatment of malariaAntenatal visitsCohort studySymptomatic womenExpert microscopyThird trimesterIntermittent screeningPregnant womenProspective studyMalaria infectionLessons learnt from 20 years surveillance of malaria drug resistance prior to the policy change in Burkina Faso.
Tinto H, Valea I, Ouédraogo J, Guiguemdé T. Lessons learnt from 20 years surveillance of malaria drug resistance prior to the policy change in Burkina Faso. Annals Of Parasitology 2016, 62: 17-24. PMID: 27262953, DOI: 10.17420/ap6201.27.Peer-Reviewed Original ResearchConceptsDrug resistanceChloroquine resistanceYear surveillanceSeasonal malaria chemoprophylaxisIntermittent preventive treatmentMalaria drug resistanceSulfadoxine-pyrimethamine resistanceSystematic surveillance systemGood surveillance systemSurveillance systemLate recrudescenceMalaria chemoprophylaxisUncomplicated malariaSulfadoxine-pyrimethamineTreatment failurePregnant womenCombination therapyDevelopment of resistancePreventive treatmentReal prevalenceTreatment resistanceLow prevalenceSentinel sitesAntimalarial drugsBurkina Faso
2015
Prevalence of the dhfr and dhps Mutations among Pregnant Women in Rural Burkina Faso Five Years after the Introduction of Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine
Tahita M, Tinto H, Erhart A, Kazienga A, Fitzhenry R, VanOvermeir C, Rosanas-Urgell A, Ouedraogo J, Guiguemde R, Van geertruyden J, D’Alessandro U. Prevalence of the dhfr and dhps Mutations among Pregnant Women in Rural Burkina Faso Five Years after the Introduction of Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine. PLOS ONE 2015, 10: e0137440. PMID: 26368675, PMCID: PMC4569438, DOI: 10.1371/journal.pone.0137440.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntimalarialsBurkina FasoDihydropteroate SynthaseDrug CombinationsDrug ResistanceFemaleHumansMalaria, FalciparumMutationPlasmodium falciparumPregnancyPregnancy Trimester, SecondPregnancy Trimester, ThirdPrevalenceProtozoan ProteinsPyrimethamineSulfadoxineTetrahydrofolate DehydrogenaseYoung AdultConceptsIntermittent preventive treatmentPregnant womenPfdhps genesPreventive treatmentAntenatal careSulfadoxine-pyrimethamineThird trimesterDhps mutationsPfdhfr mutationsMalaria infectionMalaria symptomsHealth districtPfdhfr geneBlood samplesSP resistanceI164L mutationEndemic regionsReductase mutationMalaria controlDrug resistancePrevalenceAdverse effectsFive yearsWomenBurkina FasoEx vivo anti-malarial drug susceptibility of Plasmodium falciparum isolates from pregnant women in an area of highly seasonal transmission in Burkina Faso
Tahita M, Tinto H, Yarga S, Kazienga A, Traore/Coulibaly M, Valea I, Van Overmeir C, Rosanas-Urgell A, Ouedraogo J, Guiguemde R, van Geertruyden J, Erhart A, D’Alessandro U. Ex vivo anti-malarial drug susceptibility of Plasmodium falciparum isolates from pregnant women in an area of highly seasonal transmission in Burkina Faso. Malaria Journal 2015, 14: 251. PMID: 26088768, PMCID: PMC4474342, DOI: 10.1186/s12936-015-0769-1.Peer-Reviewed Original ResearchConceptsPregnant womenAnti-malarial drugsDrug sensitivity profilesParasite densityAnti-malarial drug susceptibilityDifferent drug sensitivity profilesUncomplicated Plasmodium falciparum malariaTreatment Efficacy TrialInfected pregnant womenArtemisinin-based combinationsPlasmodium falciparum malariaChloroquine-resistant isolatesHistidine-rich protein-2 assayPlasmodium falciparum isolatesGeometric mean IC50Low parasite densitiesP. falciparum parasitesTreatment of malariaFalciparum malariaRecurrent infectionsMean IC50Efficacy trialsFalciparum isolatesMethodsThe studyResistant parasites
2013
Clinical signs and symptoms cannot reliably predict Plasmodium falciparum malaria infection in pregnant women living in an area of high seasonal transmission
Tahita M, Tinto H, Menten J, Ouedraogo J, Guiguemde R, van Geertruyden J, Erhart A, D’Alessandro U. Clinical signs and symptoms cannot reliably predict Plasmodium falciparum malaria infection in pregnant women living in an area of high seasonal transmission. Malaria Journal 2013, 12: 464. PMID: 24373481, PMCID: PMC3877878, DOI: 10.1186/1475-2875-12-464.Peer-Reviewed Original ResearchConceptsPregnant womenMalaria infectionRapid diagnostic testsCommon signsPredictive valuePlasmodium falciparum malaria infectionMajor public health problemDiagnostic testsCommon malaria symptomsHigh seasonal transmissionFalciparum malaria infectionHistory of feverSymptoms of malariaPublic health problemPositive predictive valueIntensity of transmissionClinical malariaClinical presentationGestational ageMalaria symptomsDistrict hospitalOverall prevalenceMaternity clinicsClinical signsEndemic countriesRubella seroprevalence among pregnant women in Burkina Faso
Tahita M, Hübschen J, Tarnagda Z, Ernest D, Charpentier E, Kremer J, Muller C, Ouedraogo J. Rubella seroprevalence among pregnant women in Burkina Faso. BMC Infectious Diseases 2013, 13: 164. PMID: 23556510, PMCID: PMC3623657, DOI: 10.1186/1471-2334-13-164.Peer-Reviewed Original ResearchConceptsOverall seropositivity ratePregnant womenRubella seroprevalenceSeropositivity rateNon-immune pregnant womenRubella-specific IgG antibodiesOverall immunity rateOlder age groupsRubella infectionEarly pregnancyAntibody titersRoutine immunizationCommercial ELISA kitIgG antibodiesImmunity rateRubella virusAge groupsELISA kitSerum samplesBurkina FasoWomenInternational unitsSeroprevalenceHigh percentageSerious consequences
2012
An analysis of timing and frequency of malaria infection during pregnancy in relation to the risk of low birth weight, anaemia and perinatal mortality in Burkina Faso
Valea I, Tinto H, Drabo M, Huybregts L, Sorgho H, Ouedraogo J, Guiguemde R, van Geertruyden J, Kolsteren P, D'Alessandro U, the FSP/MISAME study Group. An analysis of timing and frequency of malaria infection during pregnancy in relation to the risk of low birth weight, anaemia and perinatal mortality in Burkina Faso. Malaria Journal 2012, 11: 71. PMID: 22433778, PMCID: PMC3338396, DOI: 10.1186/1475-2875-11-71.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnemiaAntimalarialsBurkina FasoDrug Administration ScheduleDrug CombinationsFemaleHumansInfant, Low Birth WeightInfant, NewbornMalaria, FalciparumPlasmodium falciparumPregnancyPregnancy Complications, ParasiticPregnancy TrimestersProspective StudiesPyrimethamineRiskSulfadoxineTime FactorsYoung AdultConceptsLow birth weightFirst malaria infectionDoses of SPMalaria infectionBirth weightPerinatal mortalityMaternal anemiaFirst trimesterPregnant womenHigh riskBackgroundA prospective studyIntermittent preventive treatmentAntenatal care visitsHistory of feverIncidence rate ratiosCare visitsThird doseMethodsStudy participantsProspective studySecond trimesterPreventive treatmentHealth centersHealth facilitiesPregnancyInsecticidal nets
2007
Sulfadoxine-pyrimethamine efficacy and selection of Plasmodium falciparum DHFR mutations in Burkina Faso before its introduction as intermittent preventive treatment for pregnant women.
Tinto H, Ouédraogo J, Zongo I, van Overmeir C, van Marck E, Guiguemdé T, D'Alessandro U. Sulfadoxine-pyrimethamine efficacy and selection of Plasmodium falciparum DHFR mutations in Burkina Faso before its introduction as intermittent preventive treatment for pregnant women. American Journal Of Tropical Medicine And Hygiene 2007, 76: 608-13. PMID: 17426157, DOI: 10.4269/ajtmh.2007.76.608.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnimalsAntimalarialsBurkina FasoChildChild, PreschoolChloroquineDrug Administration ScheduleDrug CombinationsDrug ResistanceFemaleGenotypeHumansInfantMalaria, FalciparumMaleMutationPlasmodium falciparumPregnancyPregnancy Complications, ParasiticPyrimethamineSelection, GeneticSulfadoxineTetrahydrofolate DehydrogenaseConceptsSulfadoxine-pyrimethamine efficacyTriple dhfr mutationDHFR mutationsRecurrent parasitemiaIntermittent preventive treatmentSulfadoxine-pyrimethamine resistanceYears of ageSuch high prevalenceDihydropteroate synthetase (Pfdhps) mutationsPCR-restriction fragment length polymorphismSulfadoxine-pyrimethamineTreatment failurePregnant womenPolymerase chain reactionPreventive treatmentHigh prevalenceNew infectionsChain reactionMutant parasitesPatientsParasitemiaTreatmentFragment length polymorphismPrevalenceEfficacy