2016
Comparison of Preventive and Therapeutic Zinc Supplementation in Young Children in Burkina Faso: A Cluster-Randomized, Community-Based Trial 1–3
Becquey E, Ouédraogo C, Hess S, Rouamba N, Prince L, Ouédraogo J, Vosti S, Brown K. Comparison of Preventive and Therapeutic Zinc Supplementation in Young Children in Burkina Faso: A Cluster-Randomized, Community-Based Trial 1–3. Journal Of Nutrition 2016, 146: 2058-2066. PMID: 27489011, DOI: 10.3945/jn.116.230128.Peer-Reviewed Original ResearchConceptsTherapeutic zinc supplementationPreventive zinc supplementationZinc supplementationNonintervention controlsMalaria incidenceDiarrhea incidenceZinc-deficient populationsPrevalence of diarrheaPlasma zinc concentrationTreatment of diarrheaPrimary outcomeBurkinabe childrenMSC groupLower incidenceNIC groupStudy groupTreatment groupsPrimary analysisControl groupDiarrheaIncidenceSupplementationTrial 1Young childrenFever
2015
Comparison of methods to assess adherence to small‐quantity lipid‐based nutrient supplements (SQ‐LNS) and dispersible tablets among young Burkinabé children participating in a community‐based intervention trial
Abbeddou S, Hess S, Yakes Jimenez E, Somé J, Vosti S, Guissou R, Ouédraogo J, Brown K. Comparison of methods to assess adherence to small‐quantity lipid‐based nutrient supplements (SQ‐LNS) and dispersible tablets among young Burkinabé children participating in a community‐based intervention trial. Maternal And Child Nutrition 2015, 11: 90-104. PMID: 25521188, PMCID: PMC6860357, DOI: 10.1111/mcn.12162.Peer-Reviewed Original ResearchConceptsSmall-quantity lipid-based nutrient supplementsPlasma zinc concentrationDispersible tabletsLipid-based nutrient supplementsCaregiver-reported adherenceMonths of supplementationDisappearance rateMonths of ageSubgroup of childrenWeekly adherenceIntervention trialsClinical trialsLow adherenceSupplementation trialAdherence dataHome visitsCaregiver interviewsZinc tabletsLack of changeChildren 11Zinc concentrationsStudy outcomesObservation periodAdherenceMonthsSmall-Quantity Lipid-Based Nutrient Supplements, Regardless of Their Zinc Content, Increase Growth and Reduce the Prevalence of Stunting and Wasting in Young Burkinabe Children: A Cluster-Randomized Trial
Hess S, Abbeddou S, Jimenez E, Somé J, Vosti S, Ouédraogo Z, Guissou R, Ouédraogo J, Brown K. Small-Quantity Lipid-Based Nutrient Supplements, Regardless of Their Zinc Content, Increase Growth and Reduce the Prevalence of Stunting and Wasting in Young Burkinabe Children: A Cluster-Randomized Trial. PLOS ONE 2015, 10: e0122242. PMID: 25816354, PMCID: PMC4376671, DOI: 10.1371/journal.pone.0122242.Peer-Reviewed Original ResearchConceptsSmall-quantity lipid-based nutrient supplementsNon-intervention cohortPlacebo tabletsLipid-based nutrient supplementsYoung Burkinabe childrenOral rehydration saltsPrevalence of stuntingIncidence of diarrheaCluster-randomized trialPlasma zinc concentrationMonths of ageBaseline hemoglobinMorbidity surveillanceNutrient supplementsStandard careDiarrhea treatmentRehydration saltsAnemia prevalenceBurkinabe childrenIllness surveillanceAntimalarial therapyIntervention groupIllness treatmentZinc tabletsZinc levelsMalaria Infection Affects the Interpretation of Biomarkers of Iron and Vitamin A Status, Even After Adjusting for Systemic Inflammation, but Does Not Affect Plasma Zinc Concentrations
Wessells K, Hess S, Rouamba N, Ouedraogo Z, Ouedraogo J, Brown K. Malaria Infection Affects the Interpretation of Biomarkers of Iron and Vitamin A Status, Even After Adjusting for Systemic Inflammation, but Does Not Affect Plasma Zinc Concentrations. European Journal Of Nutrition & Food Safety 2015, 5: 721-722. DOI: 10.9734/ejnfs/2015/21049.Peer-Reviewed Original Research
2014
Asymptomatic Malaria Infection Affects the Interpretation of Biomarkers of Iron and Vitamin A Status, Even after Adjusting for Systemic Inflammation, but Does Not Affect Plasma Zinc Concentrations among Young Children in Burkina Faso
Wessells K, Hess S, Ouédraogo Z, Rouamba N, Ouédraogo J, Brown K. Asymptomatic Malaria Infection Affects the Interpretation of Biomarkers of Iron and Vitamin A Status, Even after Adjusting for Systemic Inflammation, but Does Not Affect Plasma Zinc Concentrations among Young Children in Burkina Faso. Journal Of Nutrition 2014, 144: 2050-2058. PMID: 25411038, DOI: 10.3945/jn.114.200345.Peer-Reviewed Original ResearchMeSH KeywordsAcute-Phase ProteinsAcute-Phase ReactionAdolescentAnemia, Iron-DeficiencyAsymptomatic DiseasesBiomarkersBurkina FasoChildC-Reactive ProteinCross-Sectional StudiesDietary SupplementsFemaleFerritinsHemoglobinsHumansIron, DietaryLinear ModelsMalariaMaleMicronutrientsNutritional StatusOrosomucoidPrevalenceProteinsRandomized Controlled Trials as TopicRetinol-Binding ProteinsVitamin AVitamin A DeficiencyZincConceptsAcute phase proteinsElevated acute phase proteinsAsymptomatic malaria infectionsMalaria infectionMicronutrient statusBiomarkers of ironSoluble transferrin receptorVitamin A StatusAcute phase responseIndicators of ironPlasma zinc concentrationAsymptomatic malariaAsymptomatic childrenSystemic inflammationMalaria parasitemiaHigh prevalenceA StatusPhase proteinsInterpretation of biomarkersZinc statusIron deficiencyLower RBPHRP2PrevalenceMicronutrient deficiencies
2013
Associations Between Intestinal Mucosal Function and Changes in Plasma Zinc Concentration Following Zinc Supplementation
Wessells K, Hess S, Rouamba N, Ouédraogo Z, Kellogg M, Goto R, Duggan C, Ouédraogo J, Brown K. Associations Between Intestinal Mucosal Function and Changes in Plasma Zinc Concentration Following Zinc Supplementation. Journal Of Pediatric Gastroenterology And Nutrition 2013, 57: 348-355. PMID: 23689263, PMCID: PMC4627695, DOI: 10.1097/mpg.0b013e31829b4e9e.Peer-Reviewed Original ResearchConceptsPlasma Zn concentrationsIntestinal mucosal functionMucosal functionCitrulline concentrationZn supplementationIntestinal function testsPlacebo-controlled trialMalabsorption of fatPlasma citrulline concentrationHealthy children 6Plasma zinc concentrationMonths of agePlacebo groupPlacebo supplementationUrinary lactuloseFunction testsIntestinal permeabilitySupplementation groupZinc supplementationChildren 6Vitamin AZinc absorptionDietary Zn absorptionSupplementationMineral absorption
2012
Intestinal permeability at baseline is negatively associated with change in plasma zinc concentration following short‐term zinc supplementation
Wessells K, Hess S, Ouédraogo Z, Rouamba N, Goto R, Ouédraogo J, Brown K. Intestinal permeability at baseline is negatively associated with change in plasma zinc concentration following short‐term zinc supplementation. The FASEB Journal 2012, 26: 392.2-392.2. DOI: 10.1096/fasebj.26.1_supplement.392.2.Peer-Reviewed Original ResearchPlasma zinc concentrationIntestinal permeabilityShort-term zinc supplementationAltered intestinal permeabilityIntestinal mucosal functionMalabsorption of fatRandomized community trialSubclinical enteropathyPlacebo groupPlacebo supplementationMucosal functionZinc supplementationCommunity trialSupplementation periodChildren 6Study groupSD changeVitamin ASupplementation resultsZinc concentrationsZinc absorptionEnteropathyMineral absorptionGrant funding sourcesBaseline
2011
Short-Term Zinc Supplementation with Dispersible Tablets or Zinc Sulfate Solution Yields Similar Positive Effects on Plasma Zinc Concentration of Young Children in Burkina Faso: A Randomized Controlled Trial
Wessells K, Ouédraogo Z, Rouamba N, Hess S, Ouédraogo J, Brown K. Short-Term Zinc Supplementation with Dispersible Tablets or Zinc Sulfate Solution Yields Similar Positive Effects on Plasma Zinc Concentration of Young Children in Burkina Faso: A Randomized Controlled Trial. The Journal Of Pediatrics 2011, 160: 129-135.e3. PMID: 21871635, DOI: 10.1016/j.jpeds.2011.06.051.Peer-Reviewed Original ResearchConceptsPlasma Zn concentrationsPlasma zinc concentrationPlacebo groupZinc supplementationDispersible tabletsShort-term zinc supplementationPlacebo-controlled trialMain outcome measuresYoung childrenMonths of ageControlled TrialsPlacebo solutionChildren 6Outcome measuresSD changeSupplementation resultsZinc concentrationsZinc absorptionMean plusSupplementationBurkina FasoTrialsMonthsSimilar positive effectsAgeThe effect of zinc supplementation, provided as either a liquid ZnSO4 solution or a dispersible tablet, on plasma zinc concentration among young Burkinabé children
Wessells R, Ouédraogo Z, Rouamba N, Hess S, Ouédraogo J, Brown K. The effect of zinc supplementation, provided as either a liquid ZnSO4 solution or a dispersible tablet, on plasma zinc concentration among young Burkinabé children. The FASEB Journal 2011, 25: 236.1-236.1. DOI: 10.1096/fasebj.25.1_supplement.236.1.Peer-Reviewed Original ResearchPlasma zinc concentrationPlacebo groupZinc supplementationZinc supplementsPreventive zinc supplementationDispersible tabletsCause mortalityZinc concentrationsZn concPlacebo solutionChildren 6Study populationDaily supplementSD changeWeight gainZinc deficiencyZn supplementsFurther studiesYoung childrenDifferential changesSupplementationSupplementsChildrenGroupZinc sulfate