2021
Effect of seasonal malaria chemoprevention plus azithromycin on Plasmodium falciparum transmission: gametocyte infectivity and mosquito fitness
Yaméogo K, Yerbanga R, Ouattara S, Yao F, Lefèvre T, Zongo I, Nikièma F, Compaoré Y, Tinto H, Chandramohan D, Greenwood B, Belem A, Cohuet A, Ouédraogo J. Effect of seasonal malaria chemoprevention plus azithromycin on Plasmodium falciparum transmission: gametocyte infectivity and mosquito fitness. Malaria Journal 2021, 20: 326. PMID: 34315475, PMCID: PMC8314489, DOI: 10.1186/s12936-021-03855-3.Peer-Reviewed Original ResearchConceptsAddition of azithromycinMalaria chemopreventionSulfadoxine-pyrimethamineGametocyte infectivityAsexual Plasmodium falciparumDirect membrane feeding assaysSeasonal malaria chemopreventionPlacebo-controlled trialPlasmodium falciparum transmissionMembrane feeding assaysInfectivity of gametocytesControl of malariaPresence of malariaMalaria transmission periodDays post treatmentAnopheles gambiae mosquitoesGametocyte prevalenceMethodsThe studyConclusionThis studyMalaria transmissionP. falciparumControl childrenMosquito transmissionAppropriate interventionsChemopreventionThe Duration of Protection from Azithromycin Against Malaria, Acute Respiratory, Gastrointestinal, and Skin Infections When Given Alongside Seasonal Malaria Chemoprevention: Secondary Analyses of Data from a Clinical Trial in Houndé, Burkina Faso, and Bougouni, Mali
Phiri M, Cairns M, Zongo I, Nikiema F, Diarra M, Yerbanga R, Barry A, Tapily A, Coumare S, Thera I, Kuepfer I, Milligan P, Tinto H, Dicko A, Ouédraogo J, Greenwood B, Chandramohan D, Sagara I. The Duration of Protection from Azithromycin Against Malaria, Acute Respiratory, Gastrointestinal, and Skin Infections When Given Alongside Seasonal Malaria Chemoprevention: Secondary Analyses of Data from a Clinical Trial in Houndé, Burkina Faso, and Bougouni, Mali. Clinical Infectious Diseases 2021, 73: e2379-e2386. PMID: 33417683, PMCID: PMC8492219, DOI: 10.1093/cid/ciaa1905.Peer-Reviewed Original ResearchConceptsSeasonal malaria chemopreventionMass drug administrationMalaria chemopreventionPlacebo-controlled trialEvidence of protectionDuration of protectionHospital admissionAcute respiratoryIllness episodesWeeks postadministrationClinical trialsSkin infectionsSkin conditionsDrug AdministrationProfile of protectionAzithromycinPoisson regressionChild survivalSecondary analysisBurkina FasoDifferent causesExtent of protectionChemopreventionMalariaAdministration
2020
Seasonal malaria vaccination: protocol of a phase 3 trial of seasonal vaccination with the RTS,S/AS01E vaccine, seasonal malaria chemoprevention and the combination of vaccination and chemoprevention
Chandramohan D, Dicko A, Zongo I, Sagara I, Cairns M, Kuepfer I, Diarra M, Tapily A, Issiaka D, Sanogo K, Mahamar A, Sompougdou F, Yerbanga S, Thera I, Milligan P, Tinto H, Ofori-Anyinam O, Ouedraogo J, Greenwood B. Seasonal malaria vaccination: protocol of a phase 3 trial of seasonal vaccination with the RTS,S/AS01E vaccine, seasonal malaria chemoprevention and the combination of vaccination and chemoprevention. BMJ Open 2020, 10: e035433. PMID: 32933955, PMCID: PMC7493088, DOI: 10.1136/bmjopen-2019-035433.Peer-Reviewed Original ResearchConceptsSeasonal malaria chemopreventionClinical malariaTransmission seasonMalaria chemopreventionSeasonal vaccinationDoses of RTSWeekly active surveillancePlacebo-controlled trialPhase 3 trialMalaria transmission seasonPositive blood filmPrevalence of malariaSubsequent transmission seasonSubset of childrenCombination of vaccinationBooster doseModified intentionPrimary endpointControl vaccineFirst doseMalaria vaccineActive surveillanceCase detectionRabies vaccineHealth facilitiesEvaluation of seasonal malaria chemoprevention in two areas of intense seasonal malaria transmission: Secondary analysis of a household-randomised, placebo-controlled trial in Houndé District, Burkina Faso and Bougouni District, Mali
Cairns M, Sagara I, Zongo I, Kuepfer I, Thera I, Nikiema F, Diarra M, Yerbanga S, Barry A, Tapily A, Coumare S, Milligan P, Tinto H, Ouédraogo J, Chandramohan D, Greenwood B, Djimde A, Dicko A. Evaluation of seasonal malaria chemoprevention in two areas of intense seasonal malaria transmission: Secondary analysis of a household-randomised, placebo-controlled trial in Houndé District, Burkina Faso and Bougouni District, Mali. PLOS Medicine 2020, 17: e1003214. PMID: 32822362, PMCID: PMC7442230, DOI: 10.1371/journal.pmed.1003214.Peer-Reviewed Original ResearchConceptsSeasonal malaria chemopreventionMalaria chemopreventionUncomplicated malariaTransmission seasonIntense seasonal malaria transmissionDay 28 PCRParasitological response rateUncomplicated clinical malariaPlacebo-controlled trialIncidence of hospitalisationSeasonal malaria transmissionIncidence rate ratiosBurden of malariaRapid diagnostic testsBougouni DistrictAsymptomatic malariaClinical malariaPlacebo groupStudy drugMalaria parasitaemiaAge range 3Parent trialAmodiaquine resistancePrevalence ratiosProtective efficacy
2013
Associations Between Intestinal Mucosal Function and Changes in Plasma Zinc Concentration Following Zinc Supplementation
Wessells K, Hess S, Rouamba N, Ouédraogo Z, Kellogg M, Goto R, Duggan C, Ouédraogo J, Brown K. Associations Between Intestinal Mucosal Function and Changes in Plasma Zinc Concentration Following Zinc Supplementation. Journal Of Pediatric Gastroenterology And Nutrition 2013, 57: 348-355. PMID: 23689263, PMCID: PMC4627695, DOI: 10.1097/mpg.0b013e31829b4e9e.Peer-Reviewed Original ResearchConceptsPlasma Zn concentrationsIntestinal mucosal functionMucosal functionCitrulline concentrationZn supplementationIntestinal function testsPlacebo-controlled trialMalabsorption of fatPlasma citrulline concentrationHealthy children 6Plasma zinc concentrationMonths of agePlacebo groupPlacebo supplementationUrinary lactuloseFunction testsIntestinal permeabilitySupplementation groupZinc supplementationChildren 6Vitamin AZinc absorptionDietary Zn absorptionSupplementationMineral absorption
2011
Short-Term Zinc Supplementation with Dispersible Tablets or Zinc Sulfate Solution Yields Similar Positive Effects on Plasma Zinc Concentration of Young Children in Burkina Faso: A Randomized Controlled Trial
Wessells K, Ouédraogo Z, Rouamba N, Hess S, Ouédraogo J, Brown K. Short-Term Zinc Supplementation with Dispersible Tablets or Zinc Sulfate Solution Yields Similar Positive Effects on Plasma Zinc Concentration of Young Children in Burkina Faso: A Randomized Controlled Trial. The Journal Of Pediatrics 2011, 160: 129-135.e3. PMID: 21871635, DOI: 10.1016/j.jpeds.2011.06.051.Peer-Reviewed Original ResearchConceptsPlasma Zn concentrationsPlasma zinc concentrationPlacebo groupZinc supplementationDispersible tabletsShort-term zinc supplementationPlacebo-controlled trialMain outcome measuresYoung childrenMonths of ageControlled TrialsPlacebo solutionChildren 6Outcome measuresSD changeSupplementation resultsZinc concentrationsZinc absorptionMean plusSupplementationBurkina FasoTrialsMonthsSimilar positive effectsAge
2008
Major reduction of malaria morbidity with combined vitamin A and zinc supplementation in young children in Burkina Faso: a randomized double blind trial
Zeba A, Sorgho H, Rouamba N, Zongo I, Rouamba J, Guiguemdë R, Hamer D, Mokhtar N, Ouedraogo J. Major reduction of malaria morbidity with combined vitamin A and zinc supplementation in young children in Burkina Faso: a randomized double blind trial. Nutrition Journal 2008, 7: 7. PMID: 18237394, PMCID: PMC2254644, DOI: 10.1186/1475-2891-7-7.Peer-Reviewed Original ResearchConceptsSupplemented groupZinc supplementationVitamin APlacebo groupMalaria episodesSingle doseRandomized double-blind trialFirst malaria episodeRisk of feverDouble-blind trialPlacebo-controlled trialCases of feverDaily zinc supplementationNormal immune functionRisk of infectionCross-sectional surveyMalaria control strategiesClinical malariaFever episodesMalaria morbidityMalaria casesMalaria parasite detectionImmune functionBlind trialConclusionThese results