2020
Investigating selected host and parasite factors potentially impacting upon seasonal malaria chemoprevention in Bama, Burkina Faso
Somé FA, Bazié T, Ehrlich HY, Goodwin J, Lehane A, Neya C, Zachari K, Wade M, Ouattara JM, Foy BD, Dabiré RK, Parikh S, Ouédraogo JB. Investigating selected host and parasite factors potentially impacting upon seasonal malaria chemoprevention in Bama, Burkina Faso. Malaria Journal 2020, 19: 238. PMID: 32631416, PMCID: PMC7339464, DOI: 10.1186/s12936-020-03311-8.Peer-Reviewed Original ResearchConceptsSeasonal malaria chemopreventionDay 7 concentrationsSMC administrationMalaria chemopreventionMalaria infectionDay 7 plasma concentrationsHigh malaria transmission seasonBlood spotsFirst monthPfcrt 76TPrevalence of microscopicSubmicroscopic malaria infectionMalaria transmission seasonPlasmodium falciparum infectionPfcrt K76THigh transmission settingsSequential cross-sectional surveysCross-sectional surveyNon-significant trendAmodiaquine metabolismPfmdr1 N86Malaria parasitaemiaFalciparum infectionK76TPlasma concentrations
2017
Population Pharmacokinetic Properties of Piperaquine in Falciparum Malaria: An Individual Participant Data Meta-Analysis
Hoglund RM, Workman L, Edstein MD, Thanh NX, Quang NN, Zongo I, Ouedraogo JB, Borrmann S, Mwai L, Nsanzabana C, Price RN, Dahal P, Sambol NC, Parikh S, Nosten F, Ashley EA, Phyo AP, Lwin KM, McGready R, Day NP, Guerin PJ, White NJ, Barnes KI, Tarning J. Population Pharmacokinetic Properties of Piperaquine in Falciparum Malaria: An Individual Participant Data Meta-Analysis. PLOS Medicine 2017, 14: e1002212. PMID: 28072872, PMCID: PMC5224788, DOI: 10.1371/journal.pmed.1002212.Peer-Reviewed Original ResearchConceptsPiperaquine exposureDose regimenFalciparum malariaSmall childrenLarger childrenDay 7 plasma concentrationsThree-compartment disposition modelUncomplicated Plasmodium falciparum malariaNonlinear mixed-effects modellingPopulation pharmacokinetic propertiesIndividual Participant Data Meta-AnalysisPlasmodium falciparum malariaPopulation pharmacokinetic modelData Meta-AnalysisGuideline development groupUseful therapeutic lifeYoung childrenWorldWide Antimalarial Resistance NetworkConcentration-time dataWorld Health OrganizationDose occasionPiperaquine pharmacokineticsMixed-effects modellingUncomplicated malariaDose regimens