Selected Publications

• ASCL1 Drives Tolerance to Osimertinib in EGFR Mutant Lung Cancer in Permissive Cellular Contexts.Hu B, Wiesehöfer M, de Miguel FJ, Liu Z, Chan LH, Choi J, Melnick MA, Arnal Estape A, Walther Z, Zhao D, Lopez-Giraldez F, Wurtz A, Cai G, Fan R, Gettinger S, Xiao A, Yan Q, Homer R, Nguyen DX, Politi K. Cancer Res. 2024 Apr 15. PMID: 38359163.
• Patient-Derived Models of Cancer in the NCI PDMC Consortium: Selection, Pitfalls, and Practical Recommendations.Habowski AN, Budagavi DP, Scherer SD, Aurora AB, Caligiuri G, Flynn WF, Langer EM, Brody JR, Sears RC, Foggetti G, Arnal Estape A, Nguyen DX, Politi KA, Shen X, Hsu DS, Peehl DM, Kurhanewicz J, Sriram R, Suarez M, Xiao S, Du Y, Li XN, Navone NM, Labanca E, Willey CD. Cancers (Basel). 2024 Jan 29; 2024 Jan 29. PMID: 38339316.
• Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer.de Miguel FJ, Gentile C, Feng WW, Silva SJ, Sankar A, Exposito F, Cai WL, Melnick MA, Robles-Oteiza C, Hinkley MM, Tsai JA, Hartley AV, Wei J, Wurtz A, Li F, Toki MI, Rimm DL, Homer R, Wilen CB, Xiao AZ, Qi J, Yan Q, Nguyen DX, Jänne PA, Kadoch C, Politi KA. Cancer Cell. 2023 Aug 14; 2023 Aug 3. PMID: 37541244.
• Epigenetic markers and therapeutic targets for metastasis.Kravitz CJ, Yan Q, Nguyen DX. Cancer Metastasis Rev. 2023 Jun; 2023 Jun 7. PMID: 37286865.
• Brain metastatic outgrowth and osimertinib resistance are potentiated by RhoA in EGFR-mutant lung cancer.Adua SJ, Arnal-Estapé A, Zhao M, Qi B, Liu ZZ, Kravitz C, Hulme H, Strittmatter N, López-Giráldez F, Chande S, Albert AE, Melnick MA, Hu B, Politi K, Chiang V, Colclough N, Goodwin RJA, Cross D, Smith P, Nguyen DX. Nat Commun. 2022 Dec 12; 2022 Dec 12. PMID: 36509758.
• Melanoma central nervous system metastases: An update to approaches, challenges, and opportunities.Karz A, Dimitrova M, Kleffman K, Alvarez-Breckenridge C, Atkins MB, Boire A, Bosenberg M, Brastianos P, Cahill DP, Chen Q, Ferguson S, Forsyth P, Glitza Oliva IC, Goldberg SB, Holmen SL, Knisely JPS, Merlino G, Nguyen DX, Pacold ME, Perez-Guijarro E, Smalley KSM, Tawbi HA, Wen PY, Davies MA, Kluger HM, Mehnert JM, Hernando E. Pigment Cell Melanoma Res. 2022 Nov; 2022 Sep 1. PMID: 35912544.
• Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation.Cai WL, Chen JF, Chen H, Wingrove E, Kurley SJ, Chan LH, Zhang M, Arnal-Estape A, Zhao M, Balabaki A, Li W, Yu X, Krop ED, Dou Y, Liu Y, Jin J, Westbrook TF, Nguyen DX, Yan Q. Elife. 2022 Aug 31; 2022 Aug 31. PMID: 36043466.
• Preclinical Models for the Study of Lung Cancer Pathogenesis and Therapy Development.Arnal-Estapé A, Foggetti G, Starrett JH, Nguyen DX, Politi K. Cold Spring Harb Perspect Med. 2021 Dec 1; 2021 Dec 1. PMID: 34518338.
• Measuring Faculty Effort: A Quantitative Approach That Aligns Personal and Institutional Goals in Pathology at Yale.Morrow JS, Gershkovich P, Gibson J, Gilshannon M, Kowalski D, Levi AW, Nguyen DX, Rimm DL, Xu ML, Sinard J. Acad Pathol. 2021 Jan-Dec; 2021 Oct 7. PMID: 34646939.
• Condensing and constraining WNT by TGF-β.Patel KD, Nguyen DX. Nat Cell Biol. 2021 Mar. PMID: 33723426.
• Preclinical Comparison of the Blood-brain barrier Permeability of Osimertinib with Other EGFR TKIs.Colclough N, Chen K, Johnström P, Strittmatter N, Yan Y, Wrigley GL, Schou M, Goodwin R, Varnäs K, Adua SJ, Zhao M, Nguyen DX, Maglennon G, Barton P, Atkinson J, Zhang L, Janefeldt A, Wilson J, Smith A, Takano A, Arakawa R, Kondrashov M, Malmquist J, Revunov E, Vazquez-Romero A, Moein MM, Windhorst AD, Karp NA, Finlay MRV, Ward RA, Yates JWT, Smith PD, Farde L, Cheng Z, Cross DAE. Clin Cancer Res. 2021 Jan 1; 2020 Oct 7. PMID: 33028591.
• Tumor progression and chromatin landscape of lung cancer are regulated by the lineage factor GATA6.Arnal-Estapé A, Cai WL, Albert AE, Zhao M, Stevens LE, López-Giráldez F, Patel KD, Tyagi S, Schmitt EM, Westbrook TF, Nguyen DX. Oncogene. 2020 Apr; 2020 Mar 10. PMID: 32157212.
• Specific chromatin landscapes and transcription factors couple breast cancer subtype with metastatic relapse to lung or brain.Cai WL, Greer CB, Chen JF, Arnal-Estapé A, Cao J, Yan Q, Nguyen DX. BMC Med Genomics. 2020 Mar 6; 2020 Mar 6. PMID: 32143622.
• Adaptive Protein Translation by the Integrated Stress Response Maintains the Proliferative and Migratory Capacity of Lung Adenocarcinoma Cells.Albert AE, Adua SJ, Cai WL, Arnal-Estapé A, Cline GW, Liu Z, Zhao M, Cao PD, Mariappan M, Nguyen DX. Mol Cancer Res. 2019 Dec; 2019 Sep 24. PMID: 31551255.
• Hair follicle regeneration suppresses Ras-driven oncogenic growth.Pineda CM, Gonzalez DG, Matte-Martone C, Boucher J, Lathrop E, Gallini S, Fons NR, Xin T, Tai K, Marsh E, Nguyen DX, Suozzi KC, Beronja S, Greco V. J Cell Biol. 2019 Oct 7; 2019 Sep 5. PMID: 31488583.
• Perilesional edema in brain metastases: potential causes and implications for treatment with immune therapy.Tran TT, Mahajan A, Chiang VL, Goldberg SB, Nguyen DX, Jilaveanu LB, Kluger HM. J Immunother Cancer. 2019 Jul 30; 2019 Jul 30. PMID: 31362777.
• Transcriptomic Hallmarks of Tumor Plasticity and Stromal Interactions in Brain Metastasis.Wingrove E, Liu ZZ, Patel KD, Arnal-Estapé A, Cai WL, Melnick MA, Politi K, Monteiro C, Zhu L, Valiente M, Kluger HM, Chiang VL, Nguyen DX. Cell Rep. 2019 Apr 23. PMID: 31018140.
• Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment.Stevens LE, Arnal-Estapé A, Nguyen DX. J Vis Exp. 2018 Jun 28; 2018 Jun 28. PMID: 30010648.
• Extracellular Matrix Receptor Expression in Subtypes of Lung Adenocarcinoma Potentiates Outgrowth of Micrometastases.Stevens LE, Cheung WKC, Adua SJ, Arnal-Estapé A, Zhao M, Liu Z, Brewer K, Herbst RS, Nguyen DX. Cancer Res. 2017 Apr 15; 2017 Feb 14. PMID: 28196904.
• Lineage factors and differentiation states in lung cancer progression.Cheung WK, Nguyen DX. Oncogene. 2015 Nov 19; 2015 Mar 30. PMID: 25823023.
• Sweets for a bitter end: lung cancer cell-surface protein glycosylation mediates metastatic colonization.Arnal-Estapé A, Nguyen DX. Cancer Discov. 2015 Feb. PMID: 25656895.
• Neuregulin 1-activated ERBB4 interacts with YAP to induce Hippo pathway target genes and promote cell migration.Haskins JW, Nguyen DX, Stern DF. Sci Signal. 2014 Dec 9; 2014 Dec 9. PMID: 25492965.
• The oncogenic STP axis promotes triple-negative breast cancer via degradation of the REST tumor suppressor.Karlin KL, Mondal G, Hartman JK, Tyagi S, Kurley SJ, Bland CS, Hsu TY, Renwick A, Fang JE, Migliaccio I, Callaway C, Nair A, Dominguez-Vidana R, Nguyen DX, Osborne CK, Schiff R, Yu-Lee LY, Jung SY, Edwards DP, Hilsenbeck SG, Rosen JM, Zhang XH, Shaw CA, Couch FJ, Westbrook TF. Cell Rep. 2014 Nov 20; 2014 Nov 6. PMID: 25453754.
• Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk.Zito G, Saotome I, Liu Z, Ferro EG, Sun TY, Nguyen DX, Bilguvar K, Ko CJ, Greco V. Nat Commun. 2014 Mar 26; 2014 Mar 26. PMID: 24667544.
• Histone demethylase RBP2 is critical for breast cancer progression and metastasis.Cao J, Liu Z, Cheung WK, Zhao M, Chen SY, Chan SW, Booth CJ, Nguyen DX, Yan Q. Cell Rep. 2014 Mar 13; 2014 Feb 27. PMID: 24582965.
• EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis.Breindel JL, Haskins JW, Cowell EP, Zhao M, Nguyen DX, Stern DF. Cancer Res. 2013 Aug 15; 2013 Jun 21. PMID: 23794705.
• Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis.Cheung WK, Zhao M, Liu Z, Stevens LE, Cao PD, Fang JE, Westbrook TF, Nguyen DX. Cancer Cell. 2013 Jun 10; 2013 May 23. PMID: 23707782.
• Cell lineage specification in tumor progression and metastasis.Cao PD, Cheung WK, Nguyen DX. Discov Med. 2011 Oct. PMID: 22031670.
• Tracing the origins of metastasis.Nguyen DX. J Pathol. 2011 Jan; 2010 Oct 29. PMID: 21125675.
• Modeling metastasis in the mouse.Bos PD, Nguyen DX, Massagué J. Curr Opin Pharmacol. 2010 Oct; 2010 Jul 1. PMID: 20598638.
• Tumor self-seeding by circulating cancer cells.Kim MY, Oskarsson T, Acharyya S, Nguyen DX, Zhang XH, Norton L, Massagué J. Cell. 2009 Dec 24. PMID: 20064377.
• WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis.Nguyen DX, Chiang AC, Zhang XH, Kim JY, Kris MG, Ladanyi M, Gerald WL, Massagué J. Cell. 2009 Jul 10; 2009 Jul 2. PMID: 19576624.
• Genes that mediate breast cancer metastasis to the brain.Bos PD, Zhang XH, Nadal C, Shu W, Gomis RR, Nguyen DX, Minn AJ, van de Vijver MJ, Gerald WL, Foekens JA, Massagué J. Nature. 2009 Jun 18; 2009 May 6. PMID: 19421193.
• Metastasis: from dissemination to organ-specific colonization.Nguyen DX, Bos PD, Massagué J. Nat Rev Cancer. 2009 Apr. PMID: 19308067.
• Genetic determinants of cancer metastasis.Nguyen DX, Massagué J. Nat Rev Genet. 2007 May. PMID: 17440531.
• Lung metastasis genes couple breast tumor size and metastatic spread.Minn AJ, Gupta GP, Padua D, Bos P, Nguyen DX, Nuyten D, Kreike B, Zhang Y, Wang Y, Ishwaran H, Foekens JA, van de Vijver M, Massagué J. Proc Natl Acad Sci U S A. 2007 Apr 17; 2007 Apr 9. PMID: 17420468.
• Mediators of vascular remodelling co-opted for sequential steps in lung metastasis.Gupta GP, Nguyen DX, Chiang AC, Bos PD, Kim JY, Nadal C, Gomis RR, Manova-Todorova K, Massagué J. Nature. 2007 Apr 12. PMID: 17429393.