Brain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCD

The proposed randomized, double-blind research study will use functional magnetic resonance neuroimaging using state-of-the-art HCP acquisition protocols and analytic pipelines, to identify predictors and correlates of response to an accepted first-line pharmacological treatment for obsessive-compulsive disorder.

We need both 40 matched Healthy controls for a single fMRI, as well as 80 Unmedicated participants with OCD for a randomized, double blind OCD treatment trial with 4 fMRI scans over 18 weeks.