Effects of cannabidiol and Δ9-tetrahydrocannabinol on cytochrome P450 enzymes: a systematic review
Smith S, Le G, Teopiz K, Kwan A, Rhee T, Ho R, Wu J, Cao B, Ceban F, McIntyre R. Effects of cannabidiol and Δ9-tetrahydrocannabinol on cytochrome P450 enzymes: a systematic review. Drug Metabolism Reviews 2024, 56: 164-174. PMID: 38655747, DOI: 10.1080/03602532.2024.2346767.Peer-Reviewed Original ResearchConceptsCannabinoid cannabidiolDrug-drug interactionsPsychotropic medicationsPsychotropic agentsCYP450 enzymesHigh risk of drug–drug interactionsInteraction of THCEffects of cannabidiolRisk of drug-drug interactionsInduction of CYP450 enzymesActivity of CYP450 enzymesIncreased adverse effectsPsychotropic drugsPlasma levelsClinical dataTHCClinical studiesClinicians evidenceCannabidiolHigh riskInduce cytochrome P450Clinical settingCannabisCytochrome P450 enzymesSystematic review