Number needed to treat (NNT) for ketamine and esketamine in adults with treatment-resistant depression: A systematic review and meta-analysis
Calder C, Kwan A, Teopiz K, Wong S, Rosenblat J, Mansur R, Rhee T, Ho R, Cao B, McIntyre R. Number needed to treat (NNT) for ketamine and esketamine in adults with treatment-resistant depression: A systematic review and meta-analysis. Journal Of Affective Disorders 2024, 356: 753-762. PMID: 38636712, DOI: 10.1016/j.jad.2024.04.039.Peer-Reviewed Original ResearchConceptsTreatment-resistant depressionKetamine treatmentRandomized controlled trialsUnipolar treatment-resistant depressionDefinition of treatment resistanceSystematic reviewBenefits of ketamineMeta-analysisHarm (NNHFunctional unblindingEsketamine treatmentPooled NNTNNH valuesPlacebo-controlledTreatment resistanceRacemic ketamineTherapeutic benefitLow riskNNTKetamineCalculate NNTsControlled trialsEsketamineTreat disordersClinical meaningfulness