Rolando Garcia Milian, MLS, AHIP
Biomedical Sciences Research Support Librarian and Lecturer in EpidemiologyDownloadHi-Res Photo
Cards
Additional Titles
Bioinformatics Support, Fellow of Ezra Stiles College, Medical Library
Publications Overview
- 54 Publications
- 607 Citations
- 67 Yale Co-Authors
Contact Info
Cushing/Whitney Medical Library
PO Box 208014, 333 Cedar St
New Haven, CT 06520
United States
Additional Titles
Bioinformatics Support, Fellow of Ezra Stiles College, Medical Library
Publications Overview
- 54 Publications
- 607 Citations
- 67 Yale Co-Authors
Contact Info
Cushing/Whitney Medical Library
PO Box 208014, 333 Cedar St
New Haven, CT 06520
United States
Additional Titles
Bioinformatics Support, Fellow of Ezra Stiles College, Medical Library
Publications Overview
- 54 Publications
- 607 Citations
- 67 Yale Co-Authors
Contact Info
Cushing/Whitney Medical Library
PO Box 208014, 333 Cedar St
New Haven, CT 06520
United States
About
Titles
Biomedical Sciences Research Support Librarian and Lecturer in Epidemiology
Bioinformatics Support, Fellow of Ezra Stiles College, Medical Library
Biography
Rolando oversees the Yale Medical Library Bioinformatics Support Program and is Lecturer in Epidemiology for the Environmental Health Sciences (EHS) Department, Yale School of Public Health. This end-user-centered bioinformatics program provides resources, training, consultations, and collaboration to biomedical sciences researchers at Yale including finding, retrieving, analyzing and sharing molecular datasets.
Appointments
Environmental Health Sciences
LecturerSecondary
Other Departments & Organizations
- Center for Biomedical Data Science
- Cushing/Whitney Medical Library
- Environmental Health Sciences
- NIDA Neuroproteomics Center
- Yale School of Public Health
Education & Training
- Biomedical Informatics Fellow
- Marine Biological Laboratory/ National Library of Medicine (2012)
- MLS
- Southern Connecticut State University (2012)
Research
Overview
Medical Research Interests
Chemicals and Drugs; Diseases; Genomics; Information Science; Metabolomics; Proteomics
Public Health Interests
Genetics, Genomics, Epigenetics; Toxicology
ORCID
0000-0003-1557-566X- View Lab Website
Bioinformatics Support Hub
Research at a Glance
Yale Co-Authors
Frequent collaborators of Rolando Garcia Milian's published research.
Publications Timeline
A big-picture view of Rolando Garcia Milian's research output by year.
Research Interests
Research topics Rolando Garcia Milian is interested in exploring.
David Thompson
Ying Chen, MD, PhD
TuKiet Lam, PhD, BS
Caroline Helen Johnson, PhD
Georgia Charkoftaki, PharmD, PhD
Xingguang Luo, MD
54Publications
607Citations
Proteomics
Metabolomics
Publications
Featured Publications
Peer Teaching as Bioinformatics Training Strategy: Incentives, Challenges, and Benefits
Rahman NT, Meyer C, Thakral D, Cai WL, Chen AT, Obaid R, Garcia-Milian R. Peer Teaching as Bioinformatics Training Strategy: Incentives, Challenges, and Benefits. Medical Reference Services Quarterly 2022, 41: 13-25. PMID: 35225737, DOI: 10.1080/02763869.2022.2020568.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPeer teachingProfessional development opportunitiesResearch-intensive institutionsPeer teachersClassroom managementLack of timeTeachingCommunication skillsDevelopment opportunitiesTeachersComplex conceptBioinformatics trainingPersonal experienceTraining strategySkillsChallengesPeersTraineesInstitutionsWorkshopTrainingExperienceConfidenceOpportunitiesTopic
2024
Hormone Receptor Positive HER2-negative/MammaPrint High-2 Breast Cancers Closely Resemble Triple Negative Breast Cancers.
Rios-Hoyo A, Xiong K, Dai J, Yau C, Marczyk M, Garcia-Milian R, Wolf D, Huppert L, Nanda R, Hirst G, Cobain E, van 't Veer L, Esserman L, Pusztai L. Hormone Receptor Positive HER2-negative/MammaPrint High-2 Breast Cancers Closely Resemble Triple Negative Breast Cancers. Clinical Cancer Research 2024 PMID: 39561272, DOI: 10.1158/1078-0432.ccr-24-1553.Peer-Reviewed Original ResearchAltmetricConceptsPathological complete responseEvent-free survivalBreast cancerHER2 negative breast cancerHormone receptor-positive/HER2-negativePathologic complete response ratePrognostic risk categoriesTN breast cancerNegative breast cancerGene set analysisExpression of cell cycleGene expression dataLow-risk subgroupsHigh-risk groupMammaPrint assayNeoadjuvant trialsComplete responseER statusResidual cancerPrognostic groupsClinical featuresI-SPY2Prognostic assaysExpression dataTreatment strategiesProteomic Profile of Circulating Extracellular Vesicles in the Brain after Δ9-Tetrahydrocannabinol Inhalation
Lallai V, Lam T, Garcia-Milian R, Chen Y, Fowler J, Manca L, Piomelli D, Williams K, Nairn A, Fowler C. Proteomic Profile of Circulating Extracellular Vesicles in the Brain after Δ9-Tetrahydrocannabinol Inhalation. Biomolecules 2024, 14: 1143. PMID: 39334909, PMCID: PMC11430348, DOI: 10.3390/biom14091143.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsImmediate early gene c-fosChronic THC exposureEarly gene c-fosCannabinoid 1 receptorGene c-fosSex-specific mannerTHC exposurePsychoactive componentExtracellular vesiclesCentral signaling mechanismDrug effectsTHCChoroid plexus epithelial cellsFemale ratsC-fosPlexus epithelial cellsBrainCannabisRelease of EVsRegulate intercellular communicationCerebrospinal fluidEpithelial cellsIntercellular signaling mediatorsEV signalingIntercellular communicationThe human CD47 checkpoint is targeted by an immunosuppressive Aedes aegypti salivary factor to enhance arboviral skin infectivity
Marin-Lopez A, Huck J, Esterly A, Azcutia V, Rosen C, Garcia-Milian R, Sefik E, Vidal-Pedrola G, Raduwan H, Chen T, Arora G, Halene S, Shaw A, Palm N, Flavell R, Parkos C, Thangamani S, Ring A, Fikrig E. The human CD47 checkpoint is targeted by an immunosuppressive Aedes aegypti salivary factor to enhance arboviral skin infectivity. Science Immunology 2024, 9: eadk9872. PMID: 39121194, DOI: 10.1126/sciimmunol.adk9872.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsSuppress antiviral responsesArthropod proteinsPathogen replicationAntiviral responseProtein AVertebrate hostsMosquito salivary proteinsUp-regulatedBlood feedingHuman macrophagesPleomorphic effectsSkin infectionsZika virus disseminationInhibit proinflammatory responsesSalivary proteinsProteinNatural ligandWhite blood cellsHuman skin explantsProinflammatory responseMosquito salivaVirus disseminationHuman CD47Salivary factorsArbovirus infectionAsparagine synthetase and G‐protein coupled estrogen receptor are critical responders to nutrient supply in KRAS mutant colorectal cancer
Lu L, Zhang Q, Aladelokun O, Berardi D, Shen X, Marin A, Garcia‐Milian R, Roper J, Khan S, Johnson C. Asparagine synthetase and G‐protein coupled estrogen receptor are critical responders to nutrient supply in KRAS mutant colorectal cancer. International Journal Of Cancer 2024, 156: 52-68. PMID: 39039782, PMCID: PMC11537827, DOI: 10.1002/ijc.35104.Peer-Reviewed Original ResearchCitationsConceptsG protein-coupled estrogen receptor 1KRAS mutant colorectal cancerAsparagine synthetase expressionMutant colorectal cancerColorectal cancerAsparagine synthetaseG-protein coupled estrogen receptor 1 expressionG protein-coupled estrogen receptorWild-typeAssociated with poor overall survivalAdvanced stage tumorsKRAS wild-typeProtective effect of estradiolEffects of estradiolPoor overall survivalEstrogen receptor 1Expression of asparagine synthetasePresence of estradiolIncreased caspase-3 activityDepletion inhibited cell growthColon cancer cohortNutrient supplyAdvanced tumorsOverall survivalStage tumorsInterleukin-7-based identification of liver lymphatic endothelial cells reveals their unique structural features
Yang Y, Jeong J, Su T, Lai S, Zhang P, Garcia-Milian R, Graham M, Liu X, McConnell M, Utsumi T, Pereira J, Iwakiri Y. Interleukin-7-based identification of liver lymphatic endothelial cells reveals their unique structural features. JHEP Reports 2024, 6: 101069. PMID: 38966234, PMCID: PMC11222939, DOI: 10.1016/j.jhepr.2024.101069.Peer-Reviewed Original ResearchCitationsAltmetricConceptsCell surface structuresLymphatic endothelial cellsPublished single-cell RNA-sequencingRNA-seq analysisScRNA-seq analysisSingle-cell RNA sequencingLymphatic systemEndothelial cellsInterleukin-7RNA-seqScRNA-seqExpressed genesRNA sequencingTranscriptomic changesLow abundanceI/R liver injuryGenesIsolation protocolLiver cell typesCell typesIsolation methodLiver of miceHuman liver specimensHeterozygous miceMouse liver
2023
Digital spatial profiling of melanoma shows CD95 expression in immune cells is associated with resistance to immunotherapy
Martinez-Morilla S, Moutafi M, Fernandez A, Jessel S, Divakar P, Wong P, Garcia-Milian R, Schalper K, Kluger H, Rimm D. Digital spatial profiling of melanoma shows CD95 expression in immune cells is associated with resistance to immunotherapy. OncoImmunology 2023, 12: 2260618. PMID: 37781235, PMCID: PMC10540659, DOI: 10.1080/2162402x.2023.2260618.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsDigital spatial profilingImmune checkpoint inhibitor therapyShorter progression-free survivalQuantitative immunofluorescenceCheckpoint inhibitor therapyProgression-free survivalMetastatic melanoma patientsPre-treatment specimensIndependent validation cohortMetastatic melanoma casesAdjuvant settingNanoString GeoMxMultivariable adjustmentAdverse eventsImmunotherapy cohortInhibitor therapyPD-L1Immune markersMelanoma patientsUnivariable analysisValidation cohortImmune cellsMelanoma casesMultiplex immunofluorescenceCD95 expressionAutologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironment
Chiorazzi M, Martinek J, Krasnick B, Zheng Y, Robbins K, Qu R, Kaufmann G, Skidmore Z, Juric M, Henze L, Brösecke F, Adonyi A, Zhao J, Shan L, Sefik E, Mudd J, Bi Y, Goedegebuure S, Griffith M, Griffith O, Oyedeji A, Fertuzinhos S, Garcia-Milian R, Boffa D, Detterbeck F, Dhanasopon A, Blasberg J, Judson B, Gettinger S, Politi K, Kluger Y, Palucka K, Fields R, Flavell R. Autologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironment. Journal For ImmunoTherapy Of Cancer 2023, 11: e006921. PMID: 37487666, PMCID: PMC10373695, DOI: 10.1136/jitc-2023-006921.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHuman tumor microenvironmentTumor microenvironmentTumor-immune interactionsSolid tumorsAdaptive immune activationAdaptive immune populationsIndividual tumor microenvironmentsPatient's hematopoietic systemPatient-derived xenograft tissuesVascular endothelial growth factorBone marrow hematopoietic stemBone marrow aspiratePreclinical drug testingEndothelial growth factorHematopoietic systemAutologous tumorPDX modelingPDX miceImmune activationImmune populationsMarrow aspiratesAutologous systemIndividual patientsLittermate controlsPreclinical predictionsPartnering with health sciences libraries to address challenges in bioimaging data management and sharing.
Silkotch C, Garcia-Milian R, Hersey D. Partnering with health sciences libraries to address challenges in bioimaging data management and sharing. Histochem Cell Biol 2023 PMID: 37247072, DOI: 10.1007/s00418-023-02198-1.Peer-Reviewed Original ResearchPeripheral signature of altered synaptic integrity in young onset cannabis use disorder: A proteomic study of circulating extracellular vesicles
Ganesh S, Lam T, Garcia-Milian R, D'Souza D, Nairn A, Elgert K, Eitan E, Ranganathan M. Peripheral signature of altered synaptic integrity in young onset cannabis use disorder: A proteomic study of circulating extracellular vesicles. The World Journal Of Biological Psychiatry 2023, 24: 603-613. PMID: 36994633, PMCID: PMC10471733, DOI: 10.1080/15622975.2023.2197039.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNeuron-derived extracellular vesiclesLabel-free quantification mass spectrometryProteomic studiesCannabis use disorderExtracellular vesiclesMass spectrometry proteomic analysisDifferential proteomic profilesAdapter proteinProteomic analysisPost-synaptic densityPeripheral signatureMolecular basisProteomic profilesProteinMarkers of neuropathologyBrain tissue samplesSynaptic pathologyVesiclesSynaptic integrityImmunoaffinity methodUse disordersFunctional integrityImportant insightsNeuropathologyPilot study
Academic Achievements & Community Involvement
activity Academy of Health Information Professionals
Professional OrganizationsCommittee MemberDetails04/15/2018 - Presentactivity International Society for Computational Biology
Professional OrganizationsMemberDetails2020 - Presentactivity Institutional Animal Care & Use Committee
CommitteesCommittee MemberDetails06/01/2014 - 05/01/2018
News & Links
Media
- Network representation of the research articles resulting from collaborations between Medical Library Bioinformatics Support Program and groups/departments at the YSM
News
- August 12, 2024
Protein in Mosquito Saliva Inhibits Host Immune Response
- January 29, 2023
Yale Study Finds Aging of Bone Marrow Accelerates Atherosclerotic Plaque Formation
- December 09, 2021
Yale researchers identify potential therapeutic targets for pulmonary fibrosis
- July 16, 2020Source: American Journal of Physiology-Gastrointestinal and Liver Physiology
Glucocorticoids and serum- and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrhea
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Contacts
Academic Office Number
Office Fax Number
Mailing Address
Cushing/Whitney Medical Library
PO Box 208014, 333 Cedar St
New Haven, CT 06520
United States
Locations
Bioinformatics Support Hub
Lab
Sterling Hall of Medicine
333 Cedar Street, Rm L-103
New Haven, CT 06510