Nicola Santoro, MD, PhD
Associate Professor of PediatricsDownloadHi-Res Photo
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Contact Info
Pediatric Endocrinology & Diabetes
330 Cedar Street
New Haven, CT 06511
United States
About
Titles
Associate Professor of Pediatrics
Biography
1993-1999 Student of Medicine at the Second University of Naples (Napoli – Italy)
1997-1999 Intern, Pediatrics, Department of Pediatrics Second University of Napoli (Napoli, Italy)
2000-2005 Resident, Pediatrics, Department of Pediatrics Second University of Napoli (Napoli, Italy)
2003 Visiting Scientist Human Genomics Lab directed by Dr Claude Bouchard at Pennington Biomedical Research Center (Louisiana State University), Baton Rouge, LA, USA.
2005-2008 PhD student of Pharmacology and Respiratory Pathophysiology, at the Second University of Napoli (Napoli, Italy)
2009-2010 Post doctoral research associate, Department of Pediatrics Yale University (New Haven, CT)
2011-2017 Associate Research Scientist, Department of Pediatrics, Yale University (New Haven, CT)
2017-2020 Assistant Professor, Department of Pediatrics, Yale University (New Haven, CT)
2020- Associate Professor, Department of Pediatrics, Yale University (New Haven, CT)
Appointments
Pediatric Endocrinology & Diabetes
Associate Professor on TermPrimary
Other Departments & Organizations
Education & Training
- Post doctoral research associate
- Yale University (2010)
- PhD
- Seconda Universita degli Studi di Napoli (2008)
- Residency
- Seconda Universita' degli Studi di Napoli (2005)
- MD
- Seconda Universita degli Studi di Napoli (1999)
Research
Overview
Medical Subject Headings (MeSH)
Metabolic Diseases; Nutrition Disorders
ORCID
0000-0001-6437-4173
Research at a Glance
Yale Co-Authors
Frequent collaborators of Nicola Santoro's published research.
Publications Timeline
A big-picture view of Nicola Santoro's research output by year.
Alfonso Galderisi, MD, PhD
Jessica Nouws, PhD
Michelle Van Name, MD
Sonia Caprio, MD
Stephanie Samuels, MD
Gerald I Shulman, MD, PhD, MACP, MACE, FRCP
28Publications
929Citations
Publications
2024
Adipose Tissue Insulin Resistance in Children and Adolescents: Linking Glucose and Free Fatty Acid Metabolism to Hepatic Injury Markers
Bonet J, Weiss R, Galderisi A, Man C, Caprio S, Santoro N. Adipose Tissue Insulin Resistance in Children and Adolescents: Linking Glucose and Free Fatty Acid Metabolism to Hepatic Injury Markers. AJP Endocrinology And Metabolism 2024 PMID: 39503461, DOI: 10.1152/ajpendo.00270.2024.Peer-Reviewed Original ResearchConceptsImpaired glucose toleranceInsulin sensitivity indexAlanine transaminaseInsulin resistanceFree fatty acid metabolismInsulin sensitivityP<10<sup>-6</sup>Years of follow-upMeasurement of liver function testsLiver function testsFree fatty acidsAdipose tissue insulin resistanceAdipose tissue insulin sensitivityHepatic injury markersPlasma alanine transaminaseEstimated insulin sensitivity indexTissue insulin sensitivityMann-Whitney testTissue insulin resistanceType 2 diabetesDevelopment of insulin resistanceProgression of insulin resistanceOral minimal modelCardiometabolic complicationsInsulin-resistant statesModeling Glucose, Insulin, C-Peptide, and Lactate Interplay in Adolescents During an Oral Glucose Tolerance Test.
Bonet J, Barbieri E, Santoro N, Dalla Man C. Modeling Glucose, Insulin, C-Peptide, and Lactate Interplay in Adolescents During an Oral Glucose Tolerance Test. Journal Of Diabetes Science And Technology 2024, 19322968241266825. PMID: 39076151, DOI: 10.1177/19322968241266825.Peer-Reviewed Original ResearchConceptsOral glucose tolerance testArea under the curveGlucose tolerance testC-peptideTolerance testStandard oral glucose tolerance testPathological conditionsTime coursePopulation of adolescentsClinical dataLactate metabolism pathwaysLiver diseaseSteatotic liver diseaseModel glucoseMetabolic diseasesIntersubject variabilityObesityLactate metabolismAnaerobic glycolysisInsulinLactate kineticsDiseaseAdolescentsLactateMetabolic pathwaysModelling and assessment of glucose‐lactate kinetics in youth with overweight, obesity and metabolic dysfunction‐associated steatotic liver disease: A pilot study
Bonet J, Fox D, Nelson R, Nelson M, Nelson L, Fernandez C, Barbieri E, Man C, Santoro N. Modelling and assessment of glucose‐lactate kinetics in youth with overweight, obesity and metabolic dysfunction‐associated steatotic liver disease: A pilot study. Diabetes Obesity And Metabolism 2024, 26: 3207-3212. PMID: 38742538, DOI: 10.1111/dom.15648.Peer-Reviewed Original ResearchAltmetricConceptsOral glucose tolerance testLiver diseaseSteatotic liver diseaseAssess putative differencesArea under the curveProton density fat fractionBody mass indexGlucose tolerance testTime-to-peakMann-Whitney testObese adolescentsSpearman correlation coefficientMass indexTolerance testMann-WhitneyFat fractionWilcoxon testGlucose metabolismInvestigate glucoseLactate production rateEvaluate differencesLactate metabolismObesityPutative differencesLactate kineticsObesity, Growth, Development, Metabolic Disorder, and Insulin Resistance in Pediatrics
Santoro N, Galderisi A, Caprio S. Obesity, Growth, Development, Metabolic Disorder, and Insulin Resistance in Pediatrics. 2024, vol1:608-vol1:616. DOI: 10.1201/9781003437734-70.ChaptersConceptsNonalcoholic fatty liver diseaseType 2 diabetesInsulin resistanceAdolescent obesityAssociated with precocious pubertyDevelopment of prediabetesCardiometabolic risk factorsPathogenesis of insulin resistanceFatty liver diseasePrecocious pubertyClinical peculiaritiesPediatric obesityLiver diseaseRisk factorsGlobal health challengeMetabolic disordersObesityFatty liverPathological complicationsPotential mechanismsInsulinHealth challengesChildrenComplicationsDyslipidemia
2023
Incretin effect determines glucose trajectory and insulin sensitivity in youths with obesity
Galderisi A, Tricò D, Lat J, Samuels S, Weiss R, Van Name M, Pierpont B, Santoro N, Caprio S. Incretin effect determines glucose trajectory and insulin sensitivity in youths with obesity. JCI Insight 2023, 8: e165709. PMID: 37847560, PMCID: PMC10721315, DOI: 10.1172/jci.insight.165709.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsOral glucose tolerance testΒ-cell functionIncretin effectBeta-cell functionInsulin sensitivityInsulin secretionGlucose levelsCell functionIsoglycemic intravenous glucose infusionGreater insulin sensitivityIntravenous glucose infusionPubertal transitionGlucose tolerance testGLP-17Glucagon suppressionGlucose infusionObesityLongitudinal increaseBaselineOGTTEffect groupGreater increaseLongitudinal trajectoriesSecretionGroupHigh-frequency variants in PKA signaling-related genes within a large pediatric cohort with obesity or metabolic abnormalities
Bloyd M, Sinaii N, Faucz F, Iben J, Coon S, Caprio S, Santoro N, Stratakis C, London E. High-frequency variants in PKA signaling-related genes within a large pediatric cohort with obesity or metabolic abnormalities. Frontiers In Endocrinology 2023, 14: 1272939. PMID: 38027204, PMCID: PMC10679389, DOI: 10.3389/fendo.2023.1272939.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsGenome-wide association studiesSignaling-related genesProtein kinaseHigh-frequency variantsCAMP-dependent protein kinaseLarge-scale genome-wide association studiesNew genetic associationsPDE11A geneGenomic DNAAssociation studiesMonogenic obesityTargeted exome sequencingGenesGenetic variantsEnergy metabolismGenetic associationExome sequencingNovel variantsVariant searchMetabolic characteristicsVariantsKinaseType II diabetesLociSequencingThe lncOb rs10487505 polymorphism impairs insulin sensitivity and glucose tolerance in children and adolescents with obesity
Umano G, Cirillo G, Sanchez G, Rondinelli G, Foderini M, Ferrara S, Di Sessa A, Marzuillo P, Papparella A, Santoro N, del Giudice E. The lncOb rs10487505 polymorphism impairs insulin sensitivity and glucose tolerance in children and adolescents with obesity. Obesity 2023, 31: 2359-2364. PMID: 37550829, DOI: 10.1002/oby.23835.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsHomeostasis model assessmentInsulin resistanceDisposition indexLower whole-body insulin sensitivity indexModel assessmentWhole-body insulin sensitivity indexRisk of prediabetesHigher fasting insulinLower disposition indexPlasma leptin levelsInsulin sensitivity indexBMI z-scoreLeptin plasma levelsLeptin gene transcriptionFasting insulinGlucose toleranceLeptin levelsCC patientsRetrospective studyPlasma levelsAnthropometrical evaluationInsulin sensitivityHormone levelsHigh prevalenceHigh riskProatherogenic changes in lipoprotein particles associated with a high triglyceride to high‐density lipoprotein cholesterol ratio in youths
Chiriacò M, Nesti L, Natali A, Santoro N, Caprio S, Tricò D. Proatherogenic changes in lipoprotein particles associated with a high triglyceride to high‐density lipoprotein cholesterol ratio in youths. Obesity 2023, 31: 1894-1902. PMID: 37227148, PMCID: PMC10330115, DOI: 10.1002/oby.23767.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTG/HDL ratioHigh TG/HDL ratioHigh-density lipoprotein cholesterol ratioLipoprotein cholesterol ratioHDL ratioLow-density lipoproteinHigh triglyceridesCholesterol ratioLipoprotein subclassesElevated TG/HDL ratioOral glucose tolerance testAbdominal magnetic resonance imagingIncreased cardiovascular riskTG/HDLOverweight/obesityGlucose tolerance testLipoprotein particle concentrationsIntermediate density lipoproteinPlasma lipoprotein subclassesMagnetic resonance imagingRace/ethnicityProatherogenic changesCardiovascular eventsCardiovascular riskSmall LDLComparison of Metabolic Response to Colonic Fermentation in Lean Youth vs Youth With Obesity
Galuppo B, Umano G, Li Z, Van Name M, Samuels S, Kien C, Cline G, Wagner D, Barbieri E, Tricò D, Santoro N. Comparison of Metabolic Response to Colonic Fermentation in Lean Youth vs Youth With Obesity. JAMA Network Open 2023, 6: e2312530. PMID: 37159195, PMCID: PMC10170343, DOI: 10.1001/jamanetworkopen.2023.12530.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsInsulin sensitivity indexCross-sectional studyFree fatty acidsColonic fermentationActive glucagon-like peptide-1Plasma free fatty acidsGlucagon-like peptide-1Indigestible dietary carbohydratesReduction of ghrelinActive GLP-1Health care burdenBody mass indexMetabolic responseInsulin-resistant groupLean youthObese insulinOIS groupPYY responseAnorexigenic responsePediatric obesityMass indexTyrosine tyrosineInsulin resistanceIntravenous infusionHormone secretionStudy protocol for a randomized, controlled trial using a novel, family-centered diet treatment to prevent NAFLD in Hispanic children
Welsh J, Pyo E, Huneault H, Ramirez L, Alazraki A, Alli R, Dunbar S, Khanna G, Knight-Scott J, Pimentel A, Reed B, Rodney-Somersall C, Santoro N, Umpierrez G, Vos M. Study protocol for a randomized, controlled trial using a novel, family-centered diet treatment to prevent NAFLD in Hispanic children. Contemporary Clinical Trials 2023, 129: 107170. PMID: 37019180, PMCID: PMC10734403, DOI: 10.1016/j.cct.2023.107170.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsNon-alcoholic fatty liver diseaseHispanic childrenFuture dietary guidelinesFatty liver diseasePrimary study outcomeLiver fat accumulationHigh-risk childrenSignificant hepatic steatosisOne-year interventionPercentile BMIElevated liverSecondary outcomesNAFLD preventionLiver diseaseLiver steatosisNAFLD pathogenesisPrevious diagnosisHepatic fatHepatic steatosisStudy protocolDietary guidelinesFat accumulationLiver disordersMetabolic markersEligibility criteria
Clinical Trials
Current Trials
Pathogenesis of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD)
HIC ID2000028731RolePrincipal InvestigatorPrimary Completion Date08/31/2025Recruiting ParticipantsGenderBothAge12 years - 18 yearsStudy to investigate adipocyte cell and lipid turnover in obese adolescents
HIC ID1503015459RoleSub InvestigatorPrimary Completion Date05/01/2025Recruiting ParticipantsGenderBothAge12 years - 21 yearsPrevalence of Carbohydrate Intolerance in Lean and Obese Children
HIC ID9909011190RoleSub InvestigatorPrimary Completion Date09/30/2025Recruiting ParticipantsGenderBothAge8 years - 18 years
Academic Achievements & Community Involvement
honor Young Investigator Travel Grant Award
National AwardAmerican Diabetes AssociationDetails06/17/2014United Stateshonor Yale Center for Clinical Investigation Scholar
National AwardDetails07/01/2012United Stateshonor Travel Grant
National AwardThe Obesity SocietyDetails10/12/2010United Stateshonor President Poster Award
International AwardEuropean Society for Pediatric EndocrinologyDetails09/23/2008Turkeyhonor Young Researcher Award
International AwardSecond University of NapoliDetails09/01/2000Italy
News
News
- March 25, 2020Source: Yale News
Causes of childhood obesity worldwide vary, Yale paper finds
- January 13, 2020
Yale PA Students Recognized for Outstanding Thesis Projects
- September 21, 2016
Gut bacteria differs in obese youth
- September 25, 2015
National Childhood Obesity Awareness Month
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Academic Office Number
Mailing Address
Pediatric Endocrinology & Diabetes
330 Cedar Street
New Haven, CT 06511
United States