Maggie Taylor Davis, PhD
Associate Professor of PsychiatryCards
Appointments
Contact Info
About
Titles
Associate Professor of Psychiatry
Biography
Dr. Davis is a licensed clinical psychologist and Associate Professor in the Yale Department of Psychiatry, co-appointed in the Department of Psychology. As an emergent expert in trauma-and-stressor related conditions, her work seeks to identify neurobiological mechanisms underlying behavioral responses related to PTSD, borderline personality disorder and other forms of trauma related psychopathology (e.g. eating disorders, substance use), and their link to suicide behaviors and functional impairment. Specifically, using PET imaging and fMRI Dr. Davis aims to explore novel biomarkers and potential treatment targets with the potential to reduce risk in survivors of trauma. Her current K08, R21 and R01 grants (funded my NIMH) and Young Investigator grant from the American Foundation for Suicide Prevention (AFSP) investigate the role of endogenous glutamate and opioid systems on 1) trait markers for suicide behaviors, 2) molecular and behavioral differences across biological sex, and 3) whether these systems have further implications for the risk of opiate misuse and other forms of serious comorbidity in those living with BPD and PTSD.
Beyond her personal research projects, Maggie is a specialist with expertise and clinical experience in prolonged exposure, cognitive processing therapy, cognitive behavioral therapy (various protocols) and dialectical behavior therapy (DBT). She serves as the faculty lead for data integration and research management for the Yale New Haven Health Adult Behavioral Intensive Outpatient Program (IOP). Further, Dr. Davis participated in the piloting and validation of the two most widely used assessments for PTSD in the DSM-5 (PCL-5 and the CAPS-5). Dr. Davis commits her life’s work to serving and connecting those in distress to lifesaving interventions and resources. Her impact and experience in the field spans from the treatment of individuals coping with trauma and emotion dysregulation-related symptoms to the system-wide codification of such conditions.
Appointments
Psychiatry
Associate Professor on TermPrimaryDepartment of Psychology
Assistant ProfessorSecondary
Other Departments & Organizations
- Department of Psychology
- Janeway Society
- MR Core
- Psychiatry
- Translational Brain Imaging Program
- Yale Instruction/Investigation/Intervention in Emotional Lability and Dysregulation (YIELD)
Education & Training
- Postdoctoral Fellow
- Yale University School of Medicine (2018)
- Predoctoral Intern
- University of Michigan/ VA Ann Arbor Healthcare System (2016)
- PhD
- Auburn University, Clinical Psychology (2016)
- MS
- Auburn University, Clinical Psychology (2013)
- BA
- University of Virginia, Psychology (2006)
Research
Overview
Medical Research Interests
Public Health Interests
ORCID
0000-0001-7297-710X- View Lab Website
The UPLiFT Lab
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Irina Esterlis, PhD
David Matuskey, MD
Nabeel Nabulsi, PhD
Nicole DellaGioia
John Krystal, MD
Richard Carson, PhD
Stress Disorders, Post-Traumatic
Positron-Emission Tomography
Suicide
Mental Disorders
Borderline Personality Disorder
Trauma and Stressor Related Disorders
Publications
2025
Acceptability and feasibility of a Taekwondo mindful movement intervention in Dialectical Behavior Therapy
Weiss E, Hart-Derrick V, Ramsay-Patel T, Barnes S, Anderson H, Gatti C, Davis M. Acceptability and feasibility of a Taekwondo mindful movement intervention in Dialectical Behavior Therapy. Journal Of Behavioral And Cognitive Therapy 2025, 35: 100527. PMID: 40060357, DOI: 10.1016/j.jbct.2025.100527.Peer-Reviewed Original ResearchConceptsBorderline personality disorderDialectical behavior therapyIntensive outpatient programBehavioral therapyBorderline personality disorder symptomsComparison groupTaekwondo groupDisordered eating behaviorsMovement interventionAdjunct to treatmentBinge-eating frequencyPersonality disorderMindfulness interventionTraditional mindfulnessMind-body connectionDisordered eatingOutpatient programEating behaviorsAdjunctive treatment optionSadnessPreliminary findingsHappinessGroup participantsMindfulnessIntervention
2024
An In Vivo Examination of the Relationship Between Metabotropic Glutamate 5 Receptor and Suicide Attempts in People With Borderline Personality Disorder
Davis M, Asch R, Weiss E, Wagner A, Fineberg S, Nabulsi N, Matuskey D, Carson R, Esterlis I. An In Vivo Examination of the Relationship Between Metabotropic Glutamate 5 Receptor and Suicide Attempts in People With Borderline Personality Disorder. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024, 10: 324-332. PMID: 39613160, DOI: 10.1016/j.bpsc.2024.11.014.Peer-Reviewed Original ResearchConceptsBorderline personality disorderPathophysiology of borderline personality disorderSuicide attemptsPersonality disorderPositron emission tomographyAssociated with history of suicide attemptBorderline personality disorder symptomsBPD pathophysiologyPositron emission tomography outcomes measurementsHistory of suicide attemptsMetabotropic glutamate receptor type 5Metabotropic glutamate receptor 5Glutamate receptor 5Comprehensive clinical assessmentFrontolimbic circuitsMDD groupDepressive disorderEmotion regulationPsychiatric conditionsCognitive functionMGlu5Comparison controlsMDDSuicideAssociated with historyChanges in Emotion Regulation During the Course of Dialectical Behaviour Therapy: Effects on Non‐Suicidal Self‐Injury and Binge Eating Across Two Samples
Harris L, Weiss E, Davis M, Daniel T, Hart‐Derrick V, Barnes S, Cawood C. Changes in Emotion Regulation During the Course of Dialectical Behaviour Therapy: Effects on Non‐Suicidal Self‐Injury and Binge Eating Across Two Samples. Clinical Psychology & Psychotherapy 2024, 31: e70018. PMID: 39562786, DOI: 10.1002/cpp.70018.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsNon-suicidal self-injuryEffectiveness of dialectical behavior therapyDialectical behavior therapyBinge eatingEmotion regulationBehavioral therapySelf-injuryCourse of DBTFrequency of non-suicidal self-injuryOutpatient dialectical behavior therapyAssociated with emotion dysregulationBinge eating frequencySelf-damaging behaviorsIntensive outpatient programReduce harmful behaviorsEmotion dysregulationVeteran sampleER abilitiesCivilian samplesTreatment settingsOutpatient programBingeEating frequencyCourse of treatmentHarmful behaviorMetabotropic Glutamate Receptor 5 as a Potential Biomarker of the Intersection of Trauma and Cannabis Use
Weiss E, Davis M, Asch R, D'Souza D, Cool R, Esterlis I. Metabotropic Glutamate Receptor 5 as a Potential Biomarker of the Intersection of Trauma and Cannabis Use. The International Journal Of Neuropsychopharmacology 2024, 27: pyae044. PMID: 39320043, DOI: 10.1093/ijnp/pyae044.Peer-Reviewed Original ResearchConceptsTrauma-related psychopathologyCannabis useDepressive symptomsPositron emission tomographyCross-diagnostic sampleMetabotropic glutamate receptor 5Treatment development effortsAssociated with depressive symptomsGlutamate receptor 5CU groupSample of individualsAvailability in vivoFrontolimbic regionsGlutamatergic systemGlutamatergic neurotransmissionMGlu5PsychopathologyReceptor 5Intersection of traumaExploratory analysisCannabisEmission tomographySymptomsParticipantsVmPFCMicroglia-mediated neuroimmune suppression in PTSD is associated with anhedonia
Bonomi R, Hillmer A, Woodcock E, Bhatt S, Rusowicz A, Angarita G, Carson R, Davis M, Esterlis I, Nabulsi N, Huang Y, Krystal J, Pietrzak R, Cosgrove K. Microglia-mediated neuroimmune suppression in PTSD is associated with anhedonia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2406005121. PMID: 39172786, PMCID: PMC11363315, DOI: 10.1073/pnas.2406005121.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsPTSD groupPrefrontal-limbic circuitsNeuroimmune responseAssociated with anhedoniaPosttraumatic stress disorderPositron emission tomography brain imagingTranslocator protein availabilityBrain immune functionAnhedonic symptomsStress disorderPeripheral immune dysfunctionPTSDGroup differencesSeverity of symptomsPsychiatric diseasesTranslocator proteinBrain imagingAdministration of lipopolysaccharideSymptomsMicroglial markersLPS-induced increaseCompared to controlsImmune functionSickness symptomsAnhedoniaW35 Nicotine Use and Metabotropic Glutamate Receptor 5 (mGluR5) in Individuals With Major Depressive and Post Traumatic Stress Disorders
Baldassarri S, Asch R, Hillmer A, Pietrzak R, DellaGioia N, Esterlis I, Davis M. W35 Nicotine Use and Metabotropic Glutamate Receptor 5 (mGluR5) in Individuals With Major Depressive and Post Traumatic Stress Disorders. Drug And Alcohol Dependence 2024, 260: 110653. DOI: 10.1016/j.drugalcdep.2023.110653.Peer-Reviewed Original ResearchDeficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder
Asch R, Worhunsky P, Davis M, Holmes S, Cool R, Boster S, Carson R, Blumberg H, Esterlis I. Deficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder. Journal Of Affective Disorders 2024, 361: 415-424. PMID: 38876317, PMCID: PMC11250898, DOI: 10.1016/j.jad.2024.06.025.Peer-Reviewed Original ResearchConceptsMetabotropic glutamate receptor 5Bipolar disorderGlutamate receptor 5Positron emission tomographyFear processingEmotional processingAssociated with greater activationEmotion processing taskAssociated with impulsivityFunctional brain differencesAssociated with functional alterationsParietal brain regionsPathology of BDIncreased cortical activityAssociated with difficultiesDepressive disorderHealthy comparisonReceptor availabilityBrain differencesPre/postcentral gyriAttention difficultiesGreater activationBrain regionsPsychomotor functionTreatment developmentPost-traumatic change and resilience after childhood maltreatment: Impacts on maternal mental health over the postpartum period
Armer J, Oh W, Davis M, Issa M, Sexton M, Muzik M. Post-traumatic change and resilience after childhood maltreatment: Impacts on maternal mental health over the postpartum period. Journal Of Affective Disorders 2024, 361: 1-9. PMID: 38844162, DOI: 10.1016/j.jad.2024.06.010.Peer-Reviewed Original ResearchConceptsPostpartum mental healthLow symptom classMental health symptomsMental health trajectoriesChildhood maltreatmentMental healthHealth trajectoriesHealth symptomsPost-traumatic changesAssociated with reduced psychopathologyHistory of childhood maltreatmentMaternal mental healthMental health classesPost-traumatic cognitionsMental health changesAdverse postpartum outcomesPost-traumatic growthIdentification of mothersHigh-risk classMultinomial logistic regression modelLogistic regression modelsChronic high riskGeneralizability of findingsInterview measuresHealth changesPreliminary Study of White Matter Abnormalities and Associations With the Metabotropic Glutamate Receptor 5 to Distinguish Bipolar and Major Depressive Disorders
Fan S, Asch R, Davis M, DellaGioia N, Cool R, Blumberg H, Esterlis I. Preliminary Study of White Matter Abnormalities and Associations With the Metabotropic Glutamate Receptor 5 to Distinguish Bipolar and Major Depressive Disorders. Chronic Stress 2024, 8: 24705470231225320. PMID: 38250007, PMCID: PMC10798116, DOI: 10.1177/24705470231225320.Peer-Reviewed Original ResearchConceptsMetabotropic glutamate receptor 5Bipolar disorderGlutamate receptor 5UF FAUncinate fasciculusFractional anisotropyWhole-brain analysisMultimodal neuroimaging approachDifferentiation of BDDiffusion-weighted MRI scansFrontotemporal dysconnectivityFrontotemporal systemFunctional dysconnectivityDepressive disorderNeurobiological mechanismsMGluR5 levelsWhite matterWhite matter abnormalitiesNeuroimaging approachesWM integrityNeural mechanismsMDDWhole-brainWM abnormalitiesReceptor 5Differences in Diagnostic Rules Used to Determine Borderline Personality Disorder Impact Prevalence and Associations with Clinically Relevant Variables: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions-III
Loya J, Wagner A, Pittman B, Davis M. Differences in Diagnostic Rules Used to Determine Borderline Personality Disorder Impact Prevalence and Associations with Clinically Relevant Variables: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions-III. Personality Disorders Theory Research And Treatment 2024, 15: 60-73. PMID: 38206863, PMCID: PMC10786338, DOI: 10.1037/per0000643.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsBorderline personality disorderBorderline personality disorder diagnosisPrevalence of borderline personality disorderBorderline personality disorder statusClinically relevant variablesNational Epidemiologic SurveyRelated Conditions-IIIMental health conditionsGeneralizability of findingsPersonality disorderClinical interviewClinical variablesProblem behaviorsDisorder prevalenceConditions-IIIRelevant variablesMethodological differencesEpidemiological surveyDisordersBorderlineDiagnostic rulesPrevalence ratesU.S. adultsHealth consequencesHealth conditions
Clinical Trials
Current Trials
Eligibility for Participation in Neuroimaging Studies
HIC ID2000027842RoleSub InvestigatorPrimary Completion Date12/31/2023Recruiting ParticipantsDysregulation in mGluR5 as a marker of BPD and suicide related endophenotypes
HIC ID2000023168RolePrincipal InvestigatorPrimary Completion Date10/31/2023Recruiting ParticipantsGenderBothAge18 years - 65 yearsAMPA Receptor Components of the Anti-Depressant Ketamine Response
HIC ID2000021345RoleSub InvestigatorPrimary Completion Date06/30/2032Recruiting ParticipantsGenderBothAge18 years - 65 yearsImaging mGluR5 and synaptic density in psychiatric disorders
HIC ID2000020186RoleSub InvestigatorPrimary Completion Date01/31/2018Recruiting ParticipantsGenderBothAge18 years - 80 years
Academic Achievements & Community Involvement
honor Patterson Trust Mentored Research Award
Regional AwardRobert Leet and Clara Guthrie Patterson TrustDetails02/28/2021United Stateshonor Loan Repayment Award (Clinical Research)
National AwardNIMHDetails11/01/2019United Stateshonor Early Career Investigator Travel Fellowship Award
National AwardSociety for Biological PsychiatryDetails05/17/2019United Stateshonor Yale Clinical Neuroimaging Conference Poster/ Presentation Award
Yale School of Medicine AwardYale UniversityDetails02/14/2017United States
News
News
- August 23, 2024
Microglia-Mediated Neuroimmune Suppression in PTSD Is Associated With Anhedonia
- February 23, 2021
Davis Chosen to Give Rising Star Showcase Presentation
- November 20, 2019
Yale Researchers Measure Ketamine's Effects on a Glutamate Receptor
- May 14, 2019
Biomarker Reveals PTSD Sufferers at Risk of Suicide