Alfonso Galderisi, MD, PhD
he/him/his
Assistant ProfessorCards
About
Research
Publications
2024
Adipose Tissue Insulin Resistance in Children and Adolescents: Linking Glucose and Free Fatty Acid Metabolism to Hepatic Injury Markers
Bonet J, Weiss R, Galderisi A, Man C, Caprio S, Santoro N. Adipose Tissue Insulin Resistance in Children and Adolescents: Linking Glucose and Free Fatty Acid Metabolism to Hepatic Injury Markers. AJP Endocrinology And Metabolism 2024 PMID: 39503461, DOI: 10.1152/ajpendo.00270.2024.Peer-Reviewed Original ResearchImpaired glucose toleranceInsulin sensitivity indexAlanine transaminaseInsulin resistanceFree fatty acid metabolismInsulin sensitivityP<10<sup>-6</sup>Years of follow-upMeasurement of liver function testsLiver function testsFree fatty acidsAdipose tissue insulin resistanceAdipose tissue insulin sensitivityHepatic injury markersPlasma alanine transaminaseEstimated insulin sensitivity indexTissue insulin sensitivityMann-Whitney testTissue insulin resistanceType 2 diabetesDevelopment of insulin resistanceProgression of insulin resistanceOral minimal modelCardiometabolic complicationsInsulin-resistant statesRevisiting the Pattern of Loss of β-Cell Function in Preclinical Type 1 Diabetes.
Martino M, Galderisi A, Evans-Molina C, Dayan C. Revisiting the Pattern of Loss of β-Cell Function in Preclinical Type 1 Diabetes. Diabetes 2024, 73: 1769-1779. PMID: 39106185, DOI: 10.2337/db24-0163.Peer-Reviewed Original ResearchB cell functionBeta cell lossType 1 diabetesLoss of B-cell functionCell lossOral glucose tolerance testPreclinical type 1 diabetesEarly stage diseaseBeta cell destructionTime of diagnosisDestruction of B cellsGlucose tolerance testMonths prior to clinical diagnosisAntibody positivityStage diseaseDisease activityAutoimmune destructionB cellsDisease accelerationInsulin therapyTolerance testInsulin secretionSubmaximal stimuliCell destructionGlucose controlContinuous glucose monitoring in neonates: challenges and opportunities
Puzone S, Diplomatico M, Galderisi A, Montaldo P. Continuous glucose monitoring in neonates: challenges and opportunities. Journal Of Perinatology 2024, 44: 1382-1383. PMID: 38942928, DOI: 10.1038/s41372-024-02041-y.Peer-Reviewed Original ResearchThe Impact of Antenatal Corticosteroids on the Metabolome of Preterm Newborns: An Untargeted Approach
Valerio E, Meneghelli M, Stocchero M, Galderisi A, Visentin S, Bonadies L, Pirillo P, Poloniato G, Giordano G, Baraldi E. The Impact of Antenatal Corticosteroids on the Metabolome of Preterm Newborns: An Untargeted Approach. International Journal Of Molecular Sciences 2024, 25: 5860. PMID: 38892043, PMCID: PMC11172597, DOI: 10.3390/ijms25115860.Peer-Reviewed Original ResearchAntenatal corticosteroidsPreterm infantsPreterm newbornsInvasive ventilationClinical outcomesMass spectrometry-based untargeted metabolomics analysisImpact of antenatal corticosteroidsTiming of antenatal corticosteroidsMetabolomic analysisNeonatal intensive care unitPostnatal clinical outcomesPadova University HospitalRecommended time windowUntargeted metabolomics analysisElevated levelsImprove respiratory outcomesIntensive care unitUrinary metabolomeLabor onsetAnti-inflammatory propertiesMetabolomic profilesDepartment of womenUniversity HospitalCare unitRespiratory outcomesEndpoints for clinical trials in type 1 diabetes drug development
Galderisi A, Marks B, DiMeglio L, de Beaufort C. Endpoints for clinical trials in type 1 diabetes drug development. The Lancet Diabetes & Endocrinology 2024, 12: 297-299. PMID: 38663944, PMCID: PMC11230104, DOI: 10.1016/s2213-8587(24)00097-4.Peer-Reviewed Original ResearchGlucose pattern in children with classical congenital adrenal hyperplasia: evidence from continuous glucose monitoring
Galderisi A, Kariyawasam D, Stoupa A, Quoc A, Pinto G, Viaud M, Brabant S, Beltrand J, Polak M, Samara-Boustani D. Glucose pattern in children with classical congenital adrenal hyperplasia: evidence from continuous glucose monitoring. European Journal Of Endocrinology 2024, 190: l7-l7. PMID: 38668689, DOI: 10.1093/ejendo/lvae042.Peer-Reviewed Original ResearchImpact of macronutrients intake on glycemic homeostasis of preterm infants: evidence from continuous glucose monitoring
Guiducci S, Res G, Bonadies L, Savio F, Brigadoi S, Priante E, Trevisanuto D, Baraldi E, Galderisi A. Impact of macronutrients intake on glycemic homeostasis of preterm infants: evidence from continuous glucose monitoring. European Journal Of Pediatrics 2024, 183: 3013-3018. PMID: 38637447, PMCID: PMC11192807, DOI: 10.1007/s00431-024-05532-4.Peer-Reviewed Original ResearchPreterm infantsMacronutrient intakeGlucose profilesGestational ageContinuous glucose monitoringNutritional intakeParenteral nutrient intakesGlycemic homeostasisWeeks gestational ageSensor glucoseExposure to hyperglycemiaGlucose monitoringBlood glucose profilesParenteral nutritionHigher lipid intakeMild hypoglycemiaAmino acid intakeSevere hyperglycemiaSevere hypoglycemiaAcid intakeLipid intakeNutrient intakeInfantsPretermHyperglycemiaObesity, Growth, Development, Metabolic Disorder, and Insulin Resistance in Pediatrics
Santoro N, Galderisi A, Caprio S. Obesity, Growth, Development, Metabolic Disorder, and Insulin Resistance in Pediatrics. 2024, vol1:608-vol1:616. DOI: 10.1201/9781003437734-70.ChaptersNonalcoholic fatty liver diseaseType 2 diabetesInsulin resistanceAdolescent obesityAssociated with precocious pubertyDevelopment of prediabetesCardiometabolic risk factorsPathogenesis of insulin resistanceFatty liver diseasePrecocious pubertyClinical peculiaritiesPediatric obesityLiver diseaseRisk factorsGlobal health challengeMetabolic disordersObesityFatty liverPathological complicationsPotential mechanismsInsulinHealth challengesChildrenComplicationsDyslipidemiaWilliams Textbook of Endocrinology
Chapter 36 : Digitalized Approaches to Diabetes Diagnostics and Therapeutics. Battelino T, Sherr J, Galderisi A, Dovc K. in pressChapters
2023
Incretin effect determines glucose trajectory and insulin sensitivity in youths with obesity
Galderisi A, Tricò D, Lat J, Samuels S, Weiss R, Van Name M, Pierpont B, Santoro N, Caprio S. Incretin effect determines glucose trajectory and insulin sensitivity in youths with obesity. JCI Insight 2023, 8: e165709. PMID: 37847560, PMCID: PMC10721315, DOI: 10.1172/jci.insight.165709.Peer-Reviewed Original ResearchConceptsOral glucose tolerance testΒ-cell functionIncretin effectBeta-cell functionInsulin sensitivityInsulin secretionGlucose levelsCell functionIsoglycemic intravenous glucose infusionGreater insulin sensitivityIntravenous glucose infusionPubertal transitionGlucose tolerance testGLP-17Glucagon suppressionGlucose infusionObesityLongitudinal increaseBaselineOGTTEffect groupGreater increaseLongitudinal trajectoriesSecretionGroup