Ajay Malhotra, MBBS, MD, MMM, FACR
Professor of Radiology and Biomedical Imaging and of NeurosurgeryCards
About
Titles
Professor of Radiology and Biomedical Imaging and of Neurosurgery
Biography
Avid interest in comparative-effectiveness and the practice of medicine. Love to explore the evidence behind everyday clinical decision-making, and its impact on the society both in terms of outcomes and costs.
Appointments
Radiology & Biomedical Imaging
ProfessorPrimaryNeurosurgery
ProfessorSecondary
Other Departments & Organizations
- Center for Brain & Mind Health
- Clinical Radiology
- Neuroradiology
- Neurosurgery
- Radiology & Biomedical Imaging
- Slayman House Affiliates
- Yale Biomedical Imaging Institute
- Yale Medicine
- Yale Ventures
Education & Training
- MMM
- Simon Business School (2009)
- Fellow
- University of Rochester Medical Center (2009)
- Resident
- University of Rochester Medical Center (2008)
- Fellow
- University of rochester Medical Center (2007)
- Fellow
- University of Rochester Medical Center (2006)
- Resident
- Government College (2000)
- MD
- Medical College, Amritsar, India (1999)
- MBBS
- VSS Medical College and Hospital (1996)
Research
Overview
Medical Research Interests
Health Care Economics and Organizations; Health Care Quality, Access, and Evaluation; Intracranial Aneurysm; Nervous System Diseases; Stroke
Publications
2025
Voxel-Wise Map of Intracerebral Hemorrhage Locations Associated With Worse Outcomes
Karam G, Chen M, Zeevi D, Harms B, Berson E, Torres-Lopez V, Rivier C, Malhotra A, Qureshi A, Falcone G, Sheth K, Payabvash S. Voxel-Wise Map of Intracerebral Hemorrhage Locations Associated With Worse Outcomes. Stroke 2025, 56: 868-877. PMID: 40052269, DOI: 10.1161/strokeaha.124.048453.Peer-Reviewed Original ResearchConceptsImpact of intracerebral hemorrhageAssociated with worse outcomesClinical risk factorsVoxel-wise mapsMapping of brain regionsBaseline hematomaVoxel-wise analysisHematoma volumeICH locationBrain regionsValidation cohortWorse outcomesPresence of intraventricular hemorrhageRisk factorsBaseline hematoma volumeModified Rankin Scale scorePoor scan qualityMulticenter clinical trialRankin Scale scoreDeep white matterLow-risk categoryComprehensive stroke centerIntraventricular hemorrhageConsecutive patientsPatient ageGender Wage Gap Among Academic Neurologists
Chen H, Futela D, Xie V, Bahroo L, Gandhi D, Malhotra A. Gender Wage Gap Among Academic Neurologists. Neurology 2025, 104: e213414. PMID: 39983058, DOI: 10.1212/wnl.0000000000213414.Peer-Reviewed Original ResearchFigure: Trends in proportion of part-time academic radiology faculty by gender and rank.
Malhotra A, Futela D, Gandhi D, Wu X, Payabvash S, Wintermark M, Duszak R. Figure: Trends in proportion of part-time academic radiology faculty by gender and rank. Journal Of The American College Of Radiology 2025 PMID: 39924131, DOI: 10.1016/j.jacr.2025.02.001.Peer-Reviewed Original ResearchTrends of attrition and migration in academic radiology in U.S. medical schools
Malhotra A, Futela D, Ebrahimian S, Kandala K, Gandhi D, Payabvash S, Mohan S. Trends of attrition and migration in academic radiology in U.S. medical schools. Journal Of The American College Of Radiology 2025 PMID: 39892798, DOI: 10.1016/j.jacr.2025.01.013.Peer-Reviewed Original ResearchMedical schoolsPrimary cohortAttrition ratesUS medical schoolsU.S. medical schoolsWorkforce shortagesClinical facultyRetention rateAssess trendsFull-time facultyFaculty appointmentsLongitudinal trendsAcademic radiologySecondary cohortAcademic radiology departmentsEnd pointsCohortStudy periodAttritionWomenRadiology departmentRadiology facultyRadiologyProfessor rankIndependent variablesTransient Ischemic Attack in Women: Real-World Hospitalization Incidence, Outcomes, and Risk of Hemorrhage and Stroke
Chen H, Khunte M, Colasurdo M, Majmundar S, Payabvash S, Chaturvedi S, Malhotra A, Gandhi D. Transient Ischemic Attack in Women: Real-World Hospitalization Incidence, Outcomes, and Risk of Hemorrhage and Stroke. Stroke 2025, 56: 285-293. PMID: 39869710, DOI: 10.1161/strokeaha.124.049278.Peer-Reviewed Original ResearchConceptsRates of vascular risk factorsTransient ischemic attackUS Census Bureau dataAssociated with lower oddsHigher odds of deathIschemic strokeRisk factorsAnnual incidenceTransient neurological symptomsStroke risk factorsOdds of deathLogistic regression modelsVascular risk factorsCensus Bureau dataRate of headacheRetrospective cohort studyLower oddsHigher oddsNeurological symptomsHome dischargeCohort studyIschemic attackHospital incidenceExcess hospitalizationsRisk of hemorrhageAuthor Response: Thrombectomy vs Medical Management for Posterior Cerebral Artery Stroke: Systematic Review, Meta-Analysis, and Real-World Data
Chen H, Colasurdo M, Khunte M, Malhotra A, Gandhi D. Author Response: Thrombectomy vs Medical Management for Posterior Cerebral Artery Stroke: Systematic Review, Meta-Analysis, and Real-World Data. Neurology 2025, 104: e209774. PMID: 39841951, DOI: 10.1212/wnl.0000000000209774.Peer-Reviewed Original ResearchImproving the Robustness of Deep-Learning Models in Predicting Hematoma Expansion from Admission Head CT.
Tran A, Karam G, Zeevi D, Qureshi A, Malhotra A, Majidi S, Murthy S, Park S, Kontos D, Falcone G, Sheth K, Payabvash S. Improving the Robustness of Deep-Learning Models in Predicting Hematoma Expansion from Admission Head CT. American Journal Of Neuroradiology 2025, ajnr.a8650. PMID: 39794133, DOI: 10.3174/ajnr.a8650.Peer-Reviewed Original ResearchFast Gradient Sign MethodDeep learning modelsRobustness of deep learning modelsAdversarial attacksAdversarial imagesAdversarial trainingSign MethodModel robustnessDeploying deep learning modelsDeep learning model performanceConvolutional neural networkImprove model robustnessAcute intracerebral hemorrhageHematoma expansionMulti-threshold segmentationReceiver operating characteristicIntracerebral hemorrhageGradient descentType attacksData perturbationNeural networkProjected GradientTraining setAntihypertensive Treatment of Acute Cerebral HemorrhageThreshold-based segmentationEfficacy and Safety of IV Thrombolysis for Acute Ischemic Stroke Patients With Moyamoya Disease
Chen H, Colasurdo M, Khunte M, Malhotra A, Gandhi D. Efficacy and Safety of IV Thrombolysis for Acute Ischemic Stroke Patients With Moyamoya Disease. Neurology 2025, 104: e210243. PMID: 39772663, DOI: 10.1212/wnl.0000000000210243.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeTreated with IV thrombolysisIn-hospital mortalityMoyamoya disease patientsIV thrombolysisMoyamoya diseasePropensity score matchingIntracranial hemorrhageRisk factors of acute ischemic strokeSelf-careIschemic stroke patientsAcute ischemic stroke patientsStroke patientsTreating acute ischemic strokeNationwide Readmissions DatabaseRisk factorsRate of routine dischargeRoutine dischargeEfficacy outcomesAssociated with different ratesProspective studyBypass surgeryRetrospective analysisEstablished treatmentReadmissions Database
2024
Optimizing Automated Hematoma Expansion Classification from Baseline and Follow-Up Head Computed Tomography
Tran A, Desser D, Zeevi T, Karam G, Zietz J, Dell’Orco A, Chen M, Malhotra A, Qureshi A, Murthy S, Majidi S, Falcone G, Sheth K, Nawabi J, Payabvash S. Optimizing Automated Hematoma Expansion Classification from Baseline and Follow-Up Head Computed Tomography. Applied Sciences 2024, 15: 111. PMID: 40046237, PMCID: PMC11882137, DOI: 10.3390/app15010111.Peer-Reviewed Original ResearchIntracerebral hemorrhageHematoma expansionFollow-up CT scansFollow-up head computed tomographyPredictors of poor outcomeDeep learning classification modelFollow-up scansHead computed tomographyFalse-negative resultsHematoma segmentationAutomated segmentationMulticentre cohortCT scanValidation cohortPoor outcomeComputed tomographyFollow-upClassification modelOptimizational methodHematomaAnnotationEndovascular arterial embolization versus conservative management with nasal packing alone for severe epistaxis: a nationwide cohort study
Chen H, Khunte M, Colasurdo M, Gunawardane S, Malhotra A, Gandhi D. Endovascular arterial embolization versus conservative management with nasal packing alone for severe epistaxis: a nationwide cohort study. Journal Of NeuroInterventional Surgery 2024, jnis-2024-022790. PMID: 39715667, DOI: 10.1136/jnis-2024-022790.Peer-Reviewed Original ResearchEndovascular arterial embolizationNasal packingSevere epistaxisPropensity score matchingNationwide Readmissions DatabaseArtery embolizationIschemic strokeCohort studyRates of patient morbidityHemorrhage risk factorsConservative management groupConservative managementRetrospective cohort studyNationwide cohort studyRate of ischemic strokeBalance patient characteristicsContemporary real-world dataAssociated with lower ratesPatients admitted to hospitalNon-routine dischargeRisk of ischemic strokeRecurrent epistaxisRecurrence ratePatient morbidityPatient characteristics
Clinical Care
Overview
Ajay Malhotra, MD, is a radiologist who specializes in neuroradiology. He diagnoses and treats conditions related to the nervous system, including stroke, which occurs when blood flow to the brain is interrupted, and intracranial aneurysms, a balloon-like bulge in a blood vessel.
As a professor of radiology and biomedical imaging and of neurosurgery at Yale School of Medicine, Dr. Malhotra conducts research on comparative effectiveness in neurovascular care. His work aims to explore the evidence behind clinical decision-making, assessing both outcomes and costs to improve health care quality and access. He has a deep interest in neurosciences, which drives his commitment to working with trainees and exploring the societal impact of medical practices.
Dr. Malhotra completed his medical training at VSS Medical College and Hospital in India and pursued residencies in radiology at Government College and the University of Rochester Medical Center, followed by fellowships in interventional neuroradiology, diagnostic neuroradiology, and musculoskeletal radiology at the same institution.
Clinical Specialties
Radiology & Biomedical Imaging; Neuroradiology
News
News
- January 27, 2021Source: Radiology Business
Standardizing Evaluation after Liver Cancer Treatment could Save US Healthcare More than $575M per Year
- March 20, 2018
Do patients with neck injuries really need that MRI after a normal CT?
- June 06, 2017
Risk of rupture in small brain aneurysms is low, study finds
- April 30, 2017
Library provides new tool to speed and improve systematic reviews
Get In Touch
Contacts
Academic Office Number
Clinic Fax Number
Mailing Address
Radiology & Biomedical Imaging
PO Box 208042, Tompkin's East 2
New Haven, CT 06520-8042
United States
Locations
Patient Care Locations
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