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Michael Stankewich, PhD

Associate Research Scientist in Pathology
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About

Titles

Associate Research Scientist in Pathology

Appointments

  • Pathology

    Associate Research Scientist
    Primary

Other Departments & Organizations

Education & Training

PhD
University of Massachusetts (1997)

Research

Overview

A major player of the neuronal cortical cytoskeleton is spectrin, a large and abundant scaffolding protein. The spectrin gene family is comprised of seven genes encoding two alpha and five beta subunits. To add to the complexity, many pre-mRNA splice variants have been identified. The ascribed function for spectrin is stabilizing membranes and organizing protein and lipid micro domains on both the plasma membrane and intracellular organelles. Not only is spectrin important in maintaining membrane micro domains, but also is likely involved in their targeting and transport. Salient characteristics of the spectrin gene family include: 1) a diverse neuronal compartmentalization, 2) Ca2+ /calmodulin mediated regulation, 3) calpain/caspase mediated proteolysis, and 4) tyrosine phosphorylation and ubiquination. My interest is to better elucidate the roles for such sub cellular compartmentalization and posttranslational modifications of the spectrin cytoskeleton and how spectrin affects receptor targeting, trafficking (exocytosis and endocytosis) and stabilization at pre/postsynaptic membranes.

Research at a Glance

Yale Co-Authors

Frequent collaborators of Michael Stankewich's published research.

Publications

2024

2021

2017

2014

2012

2011

2010

2005

Get In Touch

Contacts

Academic Office Number

Locations

  • Department of Pathology

    Academic Office

    Brady Memorial Laboratory

    310 Cedar Street, Ste BML 150

    New Haven, CT 06510

    Appointments

    203.785.2771