Publications

Featured Publications

BTG1 mutation yields supercompetitive B cells primed for malignant transformation
Mlynarczyk C, Teater M, Pae J, Chin C, Wang L, Arulraj T, Barisic D, Papin A, Hoehn K, Kots E, Ersching J, Bandyopadhyay A, Barin E, Poh H, Evans C, Chadburn A, Chen Z, Shen H, Isles H, Pelzer B, Tsialta I, Doane A, Geng H, Rehman M, Melnick J, Morgan W, Nguyen D, Elemento O, Kharas M, Jaffrey S, Scott D, Khelashvili G, Meyer-Hermann M, Victora G, Melnick A. BTG1 mutation yields supercompetitive B cells primed for malignant transformation. Science 2023, 379: eabj7412-eabj7412. PMID: 36656933, PMCID: PMC10515739, DOI: 10.1126/science.abj7412.
Peer-Reviewed Original Research
MeSH Keywords

2026

Pathogenesis of diffuse large B cell lymphoma proteogenotypes
Enssle J, Häupl B, Qoku A, Wang B, Wright G, Barrans S, Zhou Y, Care M, Burton C, Gribbin C, Ziello J, Weirather J, Dai Y, Kizhakeyil A, Li X, Phelan J, Kanangat S, Eckert S, Scheich S, Wolf S, Huang D, Jakob J, Perner S, Di Fonzo A, Pape M, Bodach M, Jahn D, Plessmann U, Staiger A, Ott G, Berning P, Lenz G, Hodson D, Kuster B, Schmitz R, Urlaub H, Green M, Melnick A, Tooze R, Mlynarczyk C, Inghirami G, Buettner F, Staudt L, Oellerich T. Pathogenesis of diffuse large B cell lymphoma proteogenotypes. Cancer Cell 2026 PMID: 42242231, DOI: 10.1016/j.ccell.2026.05.008.
Peer-Reviewed Original Research
SPEN loss drives extra-follicular diffuse large B cell lymphoma with female-specific lethality and therapeutic vulnerabilities
Pelzer B, Meydan C, Spiegel I, Karagiannidis I, Xia M, Teater M, Welter E, Searcy Z, Hilton L, Barisic D, Fong A, Fa P, Sethi S, Isgor I, Fielding J, Karbalayghareh A, Burdette C, Tumuluru S, Debek S, Lee S, Massoni-Badosa R, Durmaz C, Salataj E, Pararajalingam P, Chen Z, Pelzl R, Shah S, Rivas M, Hoehn K, Mlynarczyk C, Isles H, Wang X, Dogan A, Elenitoba-Johnson K, Scott D, Dreval K, Morin R, Leslie C, Puri R, Geri J, Chin C, Chadburn A, Mason C, Reinhardt H, Anguera M, Béguelin W, Venturutti L, Melnick A. SPEN loss drives extra-follicular diffuse large B cell lymphoma with female-specific lethality and therapeutic vulnerabilities. Cancer Discovery 2026, 10.1158/2159-8290.cd-25-1458. PMID: 42013317, PMCID: PMC13197974, DOI: 10.1158/2159-8290.cd-25-1458.
Peer-Reviewed Original Research

2025

T follicular helper cells transiently unlock a plasticity state in germinal centre B cells during the humoral immune response
Scourzic L, Izzo F, Teater M, Polyzos A, Cucereavii L, Chin C, Papin A, Pinto H, Mlynarczyk C, Tsialta I, Xia M, Lidoski A, Myers R, Israel E, Venturutti L, Mackay S, Hoehn K, Skoultchi A, Béguelin W, Stadtfeld M, Chen Z, Landau D, Melnick A, Apostolou E. T follicular helper cells transiently unlock a plasticity state in germinal centre B cells during the humoral immune response. Nature Cell Biology 2025, 28: 35-48. PMID: 41466145, PMCID: PMC13070251, DOI: 10.1038/s41556-025-01833-4.
Peer-Reviewed Original Research
MeSH Keywords
Rethinking the microenvironment’s role in chemical-induced malignancy
Bisson W, Currie R, Lim E, Mlynarczyk C, Tokar E, Colacci A, Colacino J. Rethinking the microenvironment’s role in chemical-induced malignancy. Toxicological Sciences 2025, 209: kfaf174. PMID: 41405843, DOI: 10.1093/toxsci/kfaf174.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
Women in STEM becoming independent: People should feel free to be themselves and do great science
Liu S, Saraiva M, Bartman C, Saurat N, Rosato P, Licona-Limon P, Mendoza A, Guthmiller J, Mlynarczyk C, Goldberg E. Women in STEM becoming independent: People should feel free to be themselves and do great science. Journal Of Experimental Medicine 2025, 222: e20251386. PMID: 40778912, DOI: 10.1084/jem.20251386.
Peer-Reviewed Original Research

2024

Tuning Responses to Polatuzumab Vedotin in B-cell Lymphoma.
Leveille E, Kothari S, Cosgun K, Mlynarczyk C, Müschen M. Tuning Responses to Polatuzumab Vedotin in B-cell Lymphoma. Cancer Discovery 2024, 14: 1577-1580. PMID: 39228298, DOI: 10.1158/2159-8290.cd-24-0644.
Peer-Reviewed Original Research
MeSH Keywords
ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis
Barisic D, Chin C, Meydan C, Teater M, Tsialta I, Mlynarczyk C, Chadburn A, Wang X, Sarkozy M, Xia M, Carson S, Raggiri S, Debek S, Pelzer B, Durmaz C, Deng Q, Lakra P, Rivas M, Steidl C, Scott D, Weng A, Mason C, Green M, Melnick A. ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis. Cancer Cell 2024, 42: 583-604.e11. PMID: 38458187, PMCID: PMC11407687, DOI: 10.1016/j.ccell.2024.02.010.
Peer-Reviewed Original Research
MeSH Keywords

2022

Conformational transitions in BTG1 antiproliferative protein and their modulation by disease mutants
Kots E, Mlynarczyk C, Melnick A, Khelashvili G. Conformational transitions in BTG1 antiproliferative protein and their modulation by disease mutants. Biophysical Journal 2022, 121: 3753-3764. PMID: 35459639, PMCID: PMC9617077, DOI: 10.1016/j.bpj.2022.04.023.
Peer-Reviewed Original Research
MeSH Keywords

2019

Germinal center‐derived lymphomas: The darkest side of humoral immunity
Mlynarczyk C, Fontán L, Melnick A. Germinal center‐derived lymphomas: The darkest side of humoral immunity. Immunological Reviews 2019, 288: 214-239. PMID: 30874354, PMCID: PMC6518944, DOI: 10.1111/imr.12755.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
MeSH Keywords

2018

In Vivo Imaging With Confirmation by Histopathology for Increased Rigor and Reproducibility in Translational Research: A Review of Examples, Options, and Resources.
Gabrielson K, Maronpot R, Monette S, Mlynarczyk C, Ramot Y, Nyska A, Sysa-Shah P. In Vivo Imaging With Confirmation by Histopathology for Increased Rigor and Reproducibility in Translational Research: A Review of Examples, Options, and Resources. ILAR Journal 2018, 59: 80-98. PMID: 30541081, PMCID: PMC6645176, DOI: 10.1093/ilar/ily010.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
MeSH Keywords

2014

Endoplasmic reticulum stress sensitizes cells to DNA damage-induced apoptosis through p53-dependent suppression of p21CDKN1A
Mlynarczyk C, Fåhraeus R. Endoplasmic reticulum stress sensitizes cells to DNA damage-induced apoptosis through p53-dependent suppression of p21CDKN1A. Nature Communications 2014, 5: 5067. PMID: 25295585, DOI: 10.1038/ncomms6067.
Peer-Reviewed Original Research
MeSH Keywords

2010

Endoplasmic Reticulum Stress Induces G2 Cell-Cycle Arrest via mRNA Translation of the p53 Isoform p53/47
Bourougaa K, Naski N, Boularan C, Mlynarczyk C, Candeias M, Marullo S, Fåhraeus R. Endoplasmic Reticulum Stress Induces G2 Cell-Cycle Arrest via mRNA Translation of the p53 Isoform p53/47. Molecular Cell 2010, 38: 78-88. PMID: 20385091, DOI: 10.1016/j.molcel.2010.01.041.
Peer-Reviewed Original Research
MeSH Keywords

Publications

Featured Publications

BTG1 mutation yields supercompetitive B cells primed for malignant transformation

2026

Pathogenesis of diffuse large B cell lymphoma proteogenotypes

SPEN loss drives extra-follicular diffuse large B cell lymphoma with female-specific lethality and therapeutic vulnerabilities

2025

T follicular helper cells transiently unlock a plasticity state in germinal centre B cells during the humoral immune response

Rethinking the microenvironment’s role in chemical-induced malignancy

Women in STEM becoming independent: People should feel free to be themselves and do great science

2024

Tuning Responses to Polatuzumab Vedotin in B-cell Lymphoma.

ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis

2022

Conformational transitions in BTG1 antiproliferative protein and their modulation by disease mutants

2020

Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells

2019

Germinal center‐derived lymphomas: The darkest side of humoral immunity

2018

In Vivo Imaging With Confirmation by Histopathology for Increased Rigor and Reproducibility in Translational Research: A Review of Examples, Options, and Resources.

2014

Endoplasmic reticulum stress sensitizes cells to DNA damage-induced apoptosis through p53-dependent suppression of p21CDKN1A

2010

Endoplasmic Reticulum Stress Induces G2 Cell-Cycle Arrest via mRNA Translation of the p53 Isoform p53/47