Publications

Featured Publications

BTG1 mutation yields supercompetitive B cells primed for malignant transformation
Mlynarczyk C, Teater M, Pae J, Chin C, Wang L, Arulraj T, Barisic D, Papin A, Hoehn K, Kots E, Ersching J, Bandyopadhyay A, Barin E, Poh H, Evans C, Chadburn A, Chen Z, Shen H, Isles H, Pelzer B, Tsialta I, Doane A, Geng H, Rehman M, Melnick J, Morgan W, Nguyen D, Elemento O, Kharas M, Jaffrey S, Scott D, Khelashvili G, Meyer-Hermann M, Victora G, Melnick A. BTG1 mutation yields supercompetitive B cells primed for malignant transformation. Science 2023, 379: eabj7412-eabj7412. PMID: 36656933, PMCID: PMC10515739, DOI: 10.1126/science.abj7412.
Peer-Reviewed Original Research
MeSH Keywords and Concepts

2026

Pathogenesis of diffuse large B cell lymphoma proteogenotypes
Enssle J, Häupl B, Qoku A, Wang B, Wright G, Barrans S, Zhou Y, Care M, Burton C, Gribbin C, Ziello J, Weirather J, Dai Y, Kizhakeyil A, Li X, Phelan J, Kanangat S, Eckert S, Scheich S, Wolf S, Huang D, Jakob J, Perner S, Di Fonzo A, Pape M, Bodach M, Jahn D, Plessmann U, Staiger A, Ott G, Berning P, Lenz G, Hodson D, Kuster B, Schmitz R, Urlaub H, Green M, Melnick A, Tooze R, Mlynarczyk C, Inghirami G, Buettner F, Staudt L, Oellerich T. Pathogenesis of diffuse large B cell lymphoma proteogenotypes. Cancer Cell 2026 PMID: 42242231, DOI: 10.1016/j.ccell.2026.05.008.
Peer-Reviewed Original Research
Concepts
SPEN loss drives extra-follicular diffuse large B cell lymphoma with female-specific lethality and therapeutic vulnerabilities
Pelzer B, Meydan C, Spiegel I, Karagiannidis I, Xia M, Teater M, Welter E, Searcy Z, Hilton L, Barisic D, Fong A, Fa P, Sethi S, Isgor I, Fielding J, Karbalayghareh A, Burdette C, Tumuluru S, Debek S, Lee S, Massoni-Badosa R, Durmaz C, Salataj E, Pararajalingam P, Chen Z, Pelzl R, Shah S, Rivas M, Hoehn K, Mlynarczyk C, Isles H, Wang X, Dogan A, Elenitoba-Johnson K, Scott D, Dreval K, Morin R, Leslie C, Puri R, Geri J, Chin C, Chadburn A, Mason C, Reinhardt H, Anguera M, Béguelin W, Venturutti L, Melnick A. SPEN loss drives extra-follicular diffuse large B cell lymphoma with female-specific lethality and therapeutic vulnerabilities. Cancer Discovery 2026, 10.1158/2159-8290.cd-25-1458. PMID: 42013317, PMCID: PMC13197974, DOI: 10.1158/2159-8290.cd-25-1458.
Peer-Reviewed Original Research
Concepts

2025

2024

2022

Conformational transitions in BTG1 antiproliferative protein and their modulation by disease mutants
Kots E, Mlynarczyk C, Melnick A, Khelashvili G. Conformational transitions in BTG1 antiproliferative protein and their modulation by disease mutants. Biophysical Journal 2022, 121: 3753-3764. PMID: 35459639, PMCID: PMC9617077, DOI: 10.1016/j.bpj.2022.04.023.
Peer-Reviewed Original Research
MeSH Keywords and Concepts

2020

Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells
Pae J, Ersching J, Castro T, Schips M, Mesin L, Allon S, Ordovas-Montanes J, Mlynarczyk C, Melnick A, Efeyan A, Shalek A, Meyer-Hermann M, Victora G. Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells. Journal Of Experimental Medicine 2020, 218: e20201699. PMID: 33332554, PMCID: PMC7754672, DOI: 10.1084/jem.20201699.
Peer-Reviewed Original Research
MeSH Keywords and Concepts

2019

Germinal center‐derived lymphomas: The darkest side of humoral immunity
Mlynarczyk C, Fontán L, Melnick A. Germinal center‐derived lymphomas: The darkest side of humoral immunity. Immunological Reviews 2019, 288: 214-239. PMID: 30874354, PMCID: PMC6518944, DOI: 10.1111/imr.12755.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
MeSH Keywords and Concepts

2018

In Vivo Imaging With Confirmation by Histopathology for Increased Rigor and Reproducibility in Translational Research: A Review of Examples, Options, and Resources.
Gabrielson K, Maronpot R, Monette S, Mlynarczyk C, Ramot Y, Nyska A, Sysa-Shah P. In Vivo Imaging With Confirmation by Histopathology for Increased Rigor and Reproducibility in Translational Research: A Review of Examples, Options, and Resources. ILAR Journal 2018, 59: 80-98. PMID: 30541081, PMCID: PMC6645176, DOI: 10.1093/ilar/ily010.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
MeSH Keywords and Concepts

2014

Endoplasmic reticulum stress sensitizes cells to DNA damage-induced apoptosis through p53-dependent suppression of p21CDKN1A
Mlynarczyk C, Fåhraeus R. Endoplasmic reticulum stress sensitizes cells to DNA damage-induced apoptosis through p53-dependent suppression of p21CDKN1A. Nature Communications 2014, 5: 5067. PMID: 25295585, DOI: 10.1038/ncomms6067.
Peer-Reviewed Original Research
MeSH Keywords and Concepts

2010

Endoplasmic Reticulum Stress Induces G2 Cell-Cycle Arrest via mRNA Translation of the p53 Isoform p53/47
Bourougaa K, Naski N, Boularan C, Mlynarczyk C, Candeias M, Marullo S, Fåhraeus R. Endoplasmic Reticulum Stress Induces G2 Cell-Cycle Arrest via mRNA Translation of the p53 Isoform p53/47. Molecular Cell 2010, 38: 78-88. PMID: 20385091, DOI: 10.1016/j.molcel.2010.01.041.
Peer-Reviewed Original Research
MeSH Keywords and Concepts