Yulai Zhou, MD, PhD
Postdoctoral AssociateAbout
Research
Publications
Featured Publications
Pathogenesis of diffuse large B cell lymphoma proteogenotypes
Enssle J, Häupl B, Qoku A, Wang B, Wright G, Barrans S, Zhou Y, Care M, Burton C, Gribbin C, Ziello J, Weirather J, Dai Y, Kizhakeyil A, Li X, Phelan J, Kanangat S, Eckert S, Scheich S, Wolf S, Huang D, Jakob J, Perner S, Di Fonzo A, Pape M, Bodach M, Jahn D, Plessmann U, Staiger A, Ott G, Berning P, Lenz G, Hodson D, Kuster B, Schmitz R, Urlaub H, Green M, Melnick A, Tooze R, Mlynarczyk C, Inghirami G, Buettner F, Staudt L, Oellerich T. Pathogenesis of diffuse large B cell lymphoma proteogenotypes. Cancer Cell 2026 PMID: 42242231, DOI: 10.1016/j.ccell.2026.05.008.Peer-Reviewed Original Research
2025
Mitochondrial gene SLC25A24 regulated anti-tumor immunity and inhibited the proliferation and metastasis of colorectal cancer by PKG1-dependent cGMP/PKG1 pathway
Gao Y, Peng Y, Zhou Y, Zhu J, Fu S, Chen Y, Cai C, Han Y, Shen H, Zeng S, Mao L, Xiao Z. Mitochondrial gene SLC25A24 regulated anti-tumor immunity and inhibited the proliferation and metastasis of colorectal cancer by PKG1-dependent cGMP/PKG1 pathway. International Immunopharmacology 2025, 157: 114664. PMID: 40334626, DOI: 10.1016/j.intimp.2025.114664.Peer-Reviewed Original ResearchQKI-induced circ_0001766 inhibits colorectal cancer progression and rapamycin resistance by miR-1203/PPP1R3C/mTOR/Myc axis
Zhou Y, Gao Y, Peng Y, Cai C, Han Y, Chen Y, Deng G, Ouyang Y, Shen H, Zeng S, Du Y, Xiao Z. QKI-induced circ_0001766 inhibits colorectal cancer progression and rapamycin resistance by miR-1203/PPP1R3C/mTOR/Myc axis. Cell Death Discovery 2025, 11: 192. PMID: 40263288, PMCID: PMC12015279, DOI: 10.1038/s41420-025-02478-w.Peer-Reviewed Original ResearchHMBOX1 reverses autophagy mediated 5-fluorouracil resistance through promoting HACE1-induced ubiquitination and degradation of ATG5 in colorectal cancer
Gao Y, Fu S, Peng Y, Zhou Y, Zhu J, Zhang X, Cai C, Han Y, Shen H, Zeng S. HMBOX1 reverses autophagy mediated 5-fluorouracil resistance through promoting HACE1-induced ubiquitination and degradation of ATG5 in colorectal cancer. Autophagy 2025, 21: 1556-1577. PMID: 40126194, PMCID: PMC12282998, DOI: 10.1080/15548627.2025.2477443.Peer-Reviewed Original Research
2024
FOS+ B cells: Key mediators of immunotherapy resistance in diverse cancer types
Zhang X, Ma J, Chen Y, Deng X, Zhang Y, Han Y, Tan J, Deng G, Ouyang Y, Zhou Y, Cai C, Zeng S, Shen H. FOS+ B cells: Key mediators of immunotherapy resistance in diverse cancer types. Molecular Therapy Oncology 2024, 32: 200895. PMID: 39583007, PMCID: PMC11584611, DOI: 10.1016/j.omton.2024.200895.Peer-Reviewed Original ResearchA humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses
Chupp D, Rivera C, Zhou Y, Xu Y, Ramsey P, Xu Z, Zan H, Casali P. A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses. Nature Immunology 2024, 25: 1489-1506. PMID: 38918608, PMCID: PMC11291283, DOI: 10.1038/s41590-024-01880-3.Peer-Reviewed Original ResearchNeuromedin U receptor 1 deletion leads to impaired immunotherapy response and high malignancy in colorectal cancer
Zhou Y, Zhang X, Gao Y, Peng Y, Liu P, Chen Y, Guo C, Deng G, Ouyang Y, Zhang Y, Han Y, Cai C, Shen H, Gao L, Zeng S. Neuromedin U receptor 1 deletion leads to impaired immunotherapy response and high malignancy in colorectal cancer. IScience 2024, 27: 110318. PMID: 39055918, PMCID: PMC11269305, DOI: 10.1016/j.isci.2024.110318.Peer-Reviewed Original Research
2023
Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells
Rivera C, Zhou Y, Chupp D, Yan H, Fisher A, Simon R, Zan H, Xu Z, Casali P. Intrinsic B cell TLR-BCR linked coengagement induces class-switched, hypermutated, neutralizing antibody responses in absence of T cells. Science Advances 2023, 9: eade8928. PMID: 37115935, PMCID: PMC10146914, DOI: 10.1126/sciadv.ade8928.Peer-Reviewed Original Research
2022
Hsa_Circ_0066351 Acts as a Prognostic and Immunotherapeutic Biomarker in Colorectal Cancer
Gao Y, Zhou Y, Wei L, Feng Z, Chen Y, Liu P, Peng Y, Huang Q, Gao L, Liu Y, Han Y, Shen H, Cai C, Zeng S. Hsa_Circ_0066351 Acts as a Prognostic and Immunotherapeutic Biomarker in Colorectal Cancer. Frontiers In Immunology 2022, 13: 927811. PMID: 36405685, PMCID: PMC9667793, DOI: 10.3389/fimmu.2022.927811.Peer-Reviewed Original ResearchIdentification of tumour immune infiltration-associated snoRNAs (TIIsno) for predicting prognosis and immune landscape in patients with colon cancer via a TIIsno score model
Cai C, Peng Y, Shen E, Wan R, Gao L, Gao Y, Zhou Y, Huang Q, Chen Y, Liu P, Guo C, Feng Z, Zhang X, Liu Y, Shen H, Zeng S, Han Y. Identification of tumour immune infiltration-associated snoRNAs (TIIsno) for predicting prognosis and immune landscape in patients with colon cancer via a TIIsno score model. EBioMedicine 2022, 76: 103866. PMID: 35144219, PMCID: PMC8844792, DOI: 10.1016/j.ebiom.2022.103866.Peer-Reviewed Original Research
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