2023
LC3 conjugation to lipid droplets
Omrane M, Melia T, Thiam A. LC3 conjugation to lipid droplets. Autophagy 2023, 19: 3251-3253. PMID: 37599471, PMCID: PMC10621252, DOI: 10.1080/15548627.2023.2249390.Peer-Reviewed Original ResearchConceptsLipid dropletsResponse to different signalsDegradation of lipid dropletsUbiquitin-conjugating enzymeLong-term-starved cellsLC3-interacting regionArtificial lipid dropletsPatatin-like phospholipase domainMicrotubule-associated protein 1 light chain 3 betaFYVE domainTethering factorsE2 enzymesLIR motifLD surfaceZinc fingerEndoplasmic reticulumLipidated LC3BPerilipin 1Phospholipase domainAutophagosome formationAssembly platformPromote degradationProlonged starvationSequestosome 1ZFYVE1/DFCP1
2021
A model for a partnership of lipid transfer proteins and scramblases in membrane expansion and organelle biogenesis
Ghanbarpour A, Valverde DP, Melia TJ, Reinisch KM. A model for a partnership of lipid transfer proteins and scramblases in membrane expansion and organelle biogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2101562118. PMID: 33850023, PMCID: PMC8072408, DOI: 10.1073/pnas.2101562118.Peer-Reviewed Original ResearchConceptsLipid transfer proteinEndoplasmic reticulumAutophagy protein ATG2Membrane dynamics processesTransfer proteinOrganelle biogenesisAutophagosome biogenesisCytosolic leafletOrganelle membranesMembrane expansionScramblasesVMP1Lipid homeostasisTMEM41BAtg9BiogenesisBulk lipidsProteinLipidsAtg2GolgiOrganellesReticulumLeafletsHomeostasis