Sox17 mediates venous adaptive remodeling after arteriovenous fistula creation
Aoyagi Y, Schwartz A, Li Z, Bai H, Ho B, Lazcano-Etchebarne C, Gonzalez L, Ohashi Y, Kano M, Yatsula B, Chaar C, Martin K, Vazquez-Padron R, Dai G, Dardik A. Sox17 mediates venous adaptive remodeling after arteriovenous fistula creation. JVS Vascular Science 2025, 6: 100392. PMID: 41127450, PMCID: PMC12538405, DOI: 10.1016/j.jvssci.2025.100392.Peer-Reviewed Original Research
Arteriovenous fistula creationHuman arteriovenous fistulaeArteriovenous fistula patencyArteriovenous fistulaMature arteriovenous fistulaVenous remodelingSOX17 expressionDay 7Endothelial cellsKnockdown miceVenous outflowBasilic vein transpositionGold standard vascular accessSmooth muscle cell proliferationSham-operated miceArteriovenous fistula maturationRates of AVF failureEnd-stage kidney diseaseControl AVFsMuscle cell proliferationSox17 knockdownStandard vascular accessAortic flow velocityPre-access veinsNuclei of endothelial cells