James W Murphy, PhD
Research Scientist in PharmacologyDownloadHi-Res Photo
Cards
Appointments
Pharmacology
Primary
Contact Info
About
Titles
Research Scientist in Pharmacology
Appointments
Pharmacology
Research ScientistPrimary
Other Departments & Organizations
- Macromolecular X-Ray Crystallography
- Pharmacology
Education & Training
- PhD
- University of Connecticut (2002)
- MS
- University of Connecticut (1996)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of James W Murphy's published research.
Elias Lolis, PhD
Manjula Ramu, PhD
Victor Batista
Publications
2021
A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase
Chen E, Reiss K, Shah D, Manjula R, Allen B, Murphy EL, Murphy JW, Batista VS, Bhandari V, Lolis EJ, Lisi GP. A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase. Journal Of Biological Chemistry 2021, 297: 101061. PMID: 34384784, PMCID: PMC8405996, DOI: 10.1016/j.jbc.2021.101061.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAllosteric SiteAmino Acid SequenceAntigens, Differentiation, B-LymphocyteBinding SitesCatalytic DomainCrystallography, X-RayCytokinesHistocompatibility Antigens Class IIHumansIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsProtein BindingStructure-Activity RelationshipConceptsAllosteric siteDopachrome tautomeraseDynamic regulatory networksEnzymatic activityLow sequence identityLigand-binding siteMultiple ligand-binding sitesNonoverlapping functionsRegulatory networksAllosteric couplingMacrophage migration inhibitory factor (MIF) familyFactor familySequence identityHomolog DStructural basisPrimary sequenceCD74 activationFunctional similarityConformational changesSolution NMRMIF-2X-ray crystallographyCatalytic siteStructural consequencesSolvent channels
2007
The Structural Biology of Chemokines
Lolis E, Murphy J. The Structural Biology of Chemokines. The Receptors 2007, 9-30. DOI: 10.1007/978-1-59745-020-1_2.Peer-Reviewed Original ResearchCitations