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Dr. Kent Langston is an assistant professor of Pathology at Yale School of Medicine and a member of the Yale Center for Research on Aging (Y-Age). He received his Ph.D. from Harvard University for his work in Dr. Tiffany Horng's laboratory on metabolic regulation of macrophage activation and tolerance. He completed his postdoctoral training with Drs. Diane Mathis and Christophe Benoist in the Department of Immunology at Harvard Medical School. In the Mathis-Benoist laboratory, Dr. Langston integrated his personal interest in exercise with his scientific interests in cellular immunology and metabolic biology to investigate how the immune system responds to exercise and regulates its beneficial effects, particularly in skeletal muscle. His work 1) elucidated the dynamics of physiological inflammatory responses to endurance exercise in skeletal muscles, 2) demonstrated that appropriate regulation of such inflammation is required for the muscle-specific and organism-level metabolic adaptations and improved performance typical of training, 3) revealed that inflammatory responses to exercise are initiated by mechanical stress-induced activation of muscle mesenchymal stromal cells. The Langston laboratory is further defining the cellular and molecular features of exercise-induced inflammatory responses in youth and during aging – an endeavor that is partly supported by an NIA/NIH K22 award – with an emphasis on elucidating how non-parenchymal cells sense exercise and regulate its benefits. An ultimate goal of this work is to design exercise-inspired interventions to combat modern afflictions associated with chronic inflammation, improve regeneration and performance after injury, reduce the pathology of musculoskeletal diseases, and combat age-related frailty (i.e., increase healthspan).