Publications

2026

Development of the authentication and authorization processes for the iAgree portal, a platform for patient-controlled data sharing across health systems
Soohoo S, Keller M, Chen Y, Hu D, Huang S, Kuo T, Leder C, Lu X, Meeker D, Morse B, Moyse H, Nagaraj G, Nguyen A, Schilling L, Soares A, Whooley M, Zheng K, Ohno-Machado L. Development of the authentication and authorization processes for the iAgree portal, a platform for patient-controlled data sharing across health systems. JAMIA Open 2026, 9: ooag111. PMID: 42344107, PMCID: PMC13289608, DOI: 10.1093/jamiaopen/ooag111.
Peer-Reviewed Original Research
Application of a machine learning model to predict the estimated primary care patient time consumption
Yu Y, Diaz J, Kuo T, Mo A, Pope Z, Hwang H, Sitapati A. Application of a machine learning model to predict the estimated primary care patient time consumption. Npj Health Systems 2026, 3: 12. PMID: 41640509, PMCID: PMC12864026, DOI: 10.1038/s44401-025-00061-0.
Peer-Reviewed Original Research

2025

False-positive tolerant model misconduct mitigation in distributed federated learning on electronic health record data across clinical institutions
Edelson M, Pham A, Kuo T. False-positive tolerant model misconduct mitigation in distributed federated learning on electronic health record data across clinical institutions. Scientific Reports 2025, 15: 23310. PMID: 40603924, PMCID: PMC12223104, DOI: 10.1038/s41598-025-04069-2.
Peer-Reviewed Original Research
MeSH Keywords
Supporting Patients in Managing Electronic Health Records and Biospecimens Consent for Research: Insights from a Mixed-Methods Usability Evaluation of the iAGREE Portal.
Hu D, Lu X, Chen Y, Keller M, Nguyen A, Le V, Kuo T, Ohno-Machado L, Zheng K. Supporting Patients in Managing Electronic Health Records and Biospecimens Consent for Research: Insights from a Mixed-Methods Usability Evaluation of the iAGREE Portal. AMIA Annual Symposium Proceedings 2025, 2024: 471-480. PMID: 41726511, PMCID: PMC12919580.
Peer-Reviewed Original Research
MeSH Keywords
Distributed cross-learning for equitable federated models - privacy-preserving prediction on data from five California hospitals
Kuo T-T, Gabriel RA, Koola J, Schooley RT, Ohno-Machado L. Distributed cross-learning for equitable federated models - privacy-preserving prediction on data from five california hospitals. Nature Communications. 2025;16(1):1371. DOI: 10.1038/s41467-025-56510-9.
Peer-Reviewed Original Research
Distributed cross-learning for equitable federated models - privacy-preserving prediction on data from five California hospitals
Kuo T, Gabriel R, Koola J, Schooley R, Ohno-Machado L. Distributed cross-learning for equitable federated models - privacy-preserving prediction on data from five California hospitals. Nature Communications 2025, 16: 1371. PMID: 39910076, PMCID: PMC11799213, DOI: 10.1038/s41467-025-56510-9.
Peer-Reviewed Original Research
MeSH Keywords
Predicting positive Clostridioides difficile test results using large-scale longitudinal data of demographics and medication history
ham A, El-Kareh R, Myers F, Ohno-Machado L, Kuo T-T. Predicting positive clostridioides difficile test results using large-scale longitudinal data of demographics and medication history. Heliyon. 2025;11(1). DOI: 10.1016/j.heliyon.2024.e41350.
Peer-Reviewed Original Research
False-positive tolerant model misconduct mitigation in distributed federated learning on electronic health record data across clinical institutions
Maxim Edelson, Anh Pham, and Tsung-Ting Kuo. “False-positive tolerant model misconduct mitigation in distributed federated learning on electronic health record data across clinical institutions.” Scientific Reports, 2025
Peer-Reviewed Original Research
Supporting Patients in Managing Electronic Health Records and Biospecimens Consent for Research: Insights from a Mixed-Methods Usability Evaluation of the iAGREE Portal
Di Hu, Xi Lu, Yunan Chen, Michelle Keller, An T. Nguyen, Vu Le, Tsung-Ting Kuo, Lucila Ohno-Machado, and Kai Zheng, “Supporting Patients in Managing Electronic Health Records and Biospecimens Consent for Research: Insights from a Mixed-Methods Usability Evaluation of the iAGREE Portal.” AMIA Annual Symposium, 2025
Peer-Reviewed Original Research

2024

Predicting positive Clostridioides difficile test results using large-scale longitudinal data of demographics and medication history
Pham A, El-Kareh R, Myers F, Ohno-Machado L, Kuo T. Predicting positive Clostridioides difficile test results using large-scale longitudinal data of demographics and medication history. Heliyon 2024, 11: e41350. PMID: 39958729, PMCID: PMC11825254, DOI: 10.1016/j.heliyon.2024.e41350.
Peer-Reviewed Original Research
Distributed, immutable, and transparent biomedical limited data set request management on multi-capacity network
Yu Y, Edelson M, Pham A, Pekar J, Johnson B, Post K, Kuo T. Distributed, immutable, and transparent biomedical limited data set request management on multi-capacity network. Journal Of The American Medical Informatics Association 2024, 32: 296-307. PMID: 39569448, PMCID: PMC11756586, DOI: 10.1093/jamia/ocae288.
Peer-Reviewed Original Research
WebQuorumChain: A web framework for quorum-based health care model learning
Shao X, Pham A, Kuo T. WebQuorumChain: A web framework for quorum-based health care model learning. Informatics In Medicine Unlocked 2024, 50: 101590. PMID: 39483487, PMCID: PMC11526443, DOI: 10.1016/j.imu.2024.101590.
Peer-Reviewed Original Research
Secure Federated Learning Integrated Statistical Modeling for Healthcare Data
Jiang X, Kim J, Kuo T, Ohno-Machado L. Secure Federated Learning Integrated Statistical Modeling for Healthcare Data. 2024, 313-324. DOI: 10.1201/9781003185284-24.
Books
Distributed management of patient data-sharing informed consents for clinical research
Pham A, Edelson M, Nouri A, Kuo T. Distributed management of patient data-sharing informed consents for clinical research. Computers In Biology And Medicine 2024, 180: 108956. PMID: 39121682, PMCID: PMC11380755, DOI: 10.1016/j.compbiomed.2024.108956.
Peer-Reviewed Original Research
Biomedical blockchain with practical implementations and quantitative evaluations: a systematic review
Lacson R, Yu Y, Kuo T, Ohno-Machado L. Biomedical blockchain with practical implementations and quantitative evaluations: a systematic review. Journal Of The American Medical Informatics Association 2024, 31: 1423-1435. PMID: 38726710, PMCID: PMC11105130, DOI: 10.1093/jamia/ocae084.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
MeSH Keywords
Early prediction of long hospital stay for Intensive Care units readmission patients using medication information
Zhang M, Kuo T. Early prediction of long hospital stay for Intensive Care units readmission patients using medication information. Computers In Biology And Medicine 2024, 174: 108451. PMID: 38603899, PMCID: PMC11385457, DOI: 10.1016/j.compbiomed.2024.108451.
Peer-Reviewed Original Research
MeSH Keywords
Secure Federated Learning Integrated Statistical Modeling for Healthcare Data
Xiaoqian Jiang, Jihoon Kim, Tsung-Ting Kuo, Lucila Ohno-Machado, “Secure Federated Learning Integrated Statistical Modeling for Healthcare Data.” Handbook of Sharing Confidential Data: Differential Privacy, Secure Multiparty Computation, and Synthetic Data, 2024.
Chapters

2023

Editorial: Blockchain and distributed ledger technology—enabled architectures for improving healthcare
Kuo T, Zhang P. Editorial: Blockchain and distributed ledger technology—enabled architectures for improving healthcare. Frontiers In Blockchain 2023, 6: 1275474. DOI: 10.3389/fbloc.2023.1275474.
Commentaries, Editorials and Letters
Blockchain-enabled immutable, distributed, and highly available clinical research activity logging system for federated COVID-19 data analysis from multiple institutions
Kuo T, Pham A, Edelson M, Kim J, Chan J, Gupta Y, Ohno-Machado L, Anderson D, Balacha C, Bath T, Baxter S, Becker-Pennrich A, Bell D, Bernstam E, Ngan C, Day M, Doctor J, DuVall S, El-Kareh R, Florian R, Follett R, Geisler B, Ghigi A, Gottlieb A, Hinske L, Hu Z, Ir D, Jiang X, Kim K, Kim J, Knight T, Koola J, Kuo T, Lee N, Mansmann U, Matheny M, Meeker D, Mou Z, Neumann L, Nguyen N, Nick A, Ohno-Machado L, Park E, Paul P, Pletcher M, Post K, Rieder C, Scherer C, Schilling L, Soares A, SooHoo S, Soysal E, Steven C, Tep B, Toy B, Wang B, Wu Z, Xu H, Yong C, Zheng K, Zhou Y, Zucker R. Blockchain-enabled immutable, distributed, and highly available clinical research activity logging system for federated COVID-19 data analysis from multiple institutions. Journal Of The American Medical Informatics Association 2023, 30: 1167-1178. PMID: 36916740, PMCID: PMC10198529, DOI: 10.1093/jamia/ocad049.
Peer-Reviewed Original Research
MeSH Keywords
A hierarchical strategy to minimize privacy risk when linking “De-identified” data in biomedical research consortia
Ohno-Machado L, Jiang X, Kuo T, Tao S, Chen L, Ram P, Zhang G, Xu H. A hierarchical strategy to minimize privacy risk when linking “De-identified” data in biomedical research consortia. Journal Of Biomedical Informatics 2023, 139: 104322. PMID: 36806328, PMCID: PMC10975485, DOI: 10.1016/j.jbi.2023.104322.
Peer-Reviewed Original Research
MeSH Keywords

2022

Quorum-based model learning on a blockchain hierarchical clinical research network using smart contracts
Kuo T, Pham A. Quorum-based model learning on a blockchain hierarchical clinical research network using smart contracts. International Journal Of Medical Informatics 2022, 169: 104924. PMID: 36402113, PMCID: PMC9984225, DOI: 10.1016/j.ijmedinf.2022.104924.
Peer-Reviewed Original Research
MeSH Keywords
The evolving privacy and security concerns for genomic data analysis and sharing as observed from the iDASH competition
Kuo T, Jiang X, Tang H, Wang X, Harmanci A, Kim M, Post K, Bu D, Bath T, Kim J, Liu W, Chen H, Ohno-Machado L. The evolving privacy and security concerns for genomic data analysis and sharing as observed from the iDASH competition. Journal Of The American Medical Informatics Association 2022, 29: 2182-2190. PMID: 36164820, PMCID: PMC9667175, DOI: 10.1093/jamia/ocac165.
Peer-Reviewed Original Research
MeSH Keywords
Predicting COVID-19 county-level case number trend by combining demographic characteristics and social distancing policies
Li M, Pham A, Kuo T. Predicting COVID-19 county-level case number trend by combining demographic characteristics and social distancing policies. JAMIA Open 2022, 5: ooac056. PMID: 35855422, PMCID: PMC9278037, DOI: 10.1093/jamiaopen/ooac056.
Peer-Reviewed Original Research
NLM’s sponsorship of research in biomedical informatics (1985–2016)
Kuo T, Ohno-Machado L. NLM’s sponsorship of research in biomedical informatics (1985–2016). Information Services & Use 2022, 42: 61-70. PMID: 35600120, PMCID: PMC9108565, DOI: 10.3233/isu-210137.
Peer-Reviewed Original Research
Generalizable prediction of COVID-19 mortality on worldwide patient data
Edelson M, Kuo T. Generalizable prediction of COVID-19 mortality on worldwide patient data. JAMIA Open 2022, 5: ooac036. PMID: 35663116, PMCID: PMC9129227, DOI: 10.1093/jamiaopen/ooac036.
Peer-Reviewed Original Research

See All Publications

Publications

2026

2025

Predicting positive Clostridioides difficile test results using large-scale longitudinal data of demographics and medication history

Supporting Patients in Managing Electronic Health Records and Biospecimens Consent for Research: Insights from a Mixed-Methods Usability Evaluation of the iAGREE Portal

2024

Secure Federated Learning Integrated Statistical Modeling for Healthcare Data

2023

2022