2014
Synthesis of Stabilized Alpha-Helical Peptides
Bernal F, Katz SG. Synthesis of Stabilized Alpha-Helical Peptides. Methods In Molecular Biology 2014, 1176: 107-114. PMID: 25030922, PMCID: PMC6333094, DOI: 10.1007/978-1-4939-0992-6_9.Peer-Reviewed Original ResearchConceptsAlpha-helical peptidesImportant protein-protein interactionsSpecific amino acid residuesProtein-protein interactionsAlpha-helical motifOlefin metathesis reactionsAlpha-helical structureRing-closing olefin metathesis reactionAmino acid residuesPosttranslational modificationsProtein interactionsMetathesis reactionHost proteinsProtein targetsAcid residuesCrystal structureSecondary structureFunctional consequencesRemarkable stabilitySmall moleculesMost peptidesInteraction sitesStructural studiesCell permeabilitySynthesis
2012
A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers
LaBelle JL, Katz SG, Bird GH, Gavathiotis E, Stewart ML, Lawrence C, Fisher JK, Godes M, Pitter K, Kung AL, Walensky LD. A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers. Journal Of Clinical Investigation 2012, 122: 2018-2031. PMID: 22622039, PMCID: PMC3366394, DOI: 10.1172/jci46231.Peer-Reviewed Original ResearchConceptsBcl-2 family proteinsCell deathFamily proteinsPro-apoptotic Bcl-2 family proteinsBcl-2 protein familyBcl-2-interacting mediatorBcl-2 family pathwayHydrocarbon-stapled peptidesCell death mechanismsCancer cellsCellular lifeHematologic cancer cellsProtein familyDeath domainBH3 helixBim BH3Bim peptidesDeath mechanismsApoptotic blockadesApoptotic resistanceFamily pathwaySurvival pathwaysAntiapoptotic proteinsProapoptotic activityHuman AML xenograft model