Characterization of cancer genomic heterogeneity by next-generation sequencing advances precision medicine in cancer treatment
Zhang J, Späth SS, Marjani SL, Zhang W, Pan X. Characterization of cancer genomic heterogeneity by next-generation sequencing advances precision medicine in cancer treatment. Precision Clinical Medicine 2018, 1: 29-48. PMID: 30687561, PMCID: PMC6333046, DOI: 10.1093/pcmedi/pby007.Peer-Reviewed Original ResearchNew next-generation sequencing technologiesGenomic heterogeneityNext-generation sequencing technologiesLarge-scale genomic studiesDiverse cell populationsGenomic studiesKey genesNext-generation sequencingSequencing technologiesSpecific molecular biomarkersGenomic alterationsNew therapeutic discoveriesGenomicsTherapeutic discoveryUnique genomicsCell populationsTumor developmentTCGA databaseMolecular heterogeneityPhenotypic featuresMolecular biomarkersMost common cancersPrecision medicineTumor heterogeneityTumor genomics