Publications

• Eosinophilia Is a Favorable Marker for Pneumonia in Chronic Obstructive Pulmonary Disease.Gu KM, Jung JW, Kang MJ, Kim DK, Choi H, Cho YJ, Jang SH, Lee CH, Oh YM, Park JS, Kim JY. Tuberc Respir Dis (Seoul). 2024 Oct; 2024 May 3. PMID: 38710525.
• The serotype-specific prevalence of pneumococci in hospitalized pneumonia patients with COPD: a prospective, multi-center, cohort study.Kim JY, Jung JW, Kang MJ, Kim DK, Choi H, Cho YJ, Jang SH, Lee CH, Oh YM, Park JS. Korean J Intern Med. 2023 Sep; 2023 Aug 17. PMID: 37586811.
• VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis.Kim SH, Adams TS, Hu Q, Shin HJ, Chae G, Lee SE, Sharma L, Kwon HK, Lee FY, Park HJ, Huh WJ, Manning E, Kaminski N, Sauler M, Chen L, Song JW, Kim TK, Kang MJ. Am J Respir Cell Mol Biol. 2023 Jul. PMID: 36450109.
• Genomic analysis of plasma circulating tumor DNA in patients with heavily pretreated HER2 + metastatic breast cancer.Lee K, Lee J, Choi J, Sim SH, Kim JE, Kim MH, Park YH, Kim JH, Koh SJ, Park KH, Kang MJ, Ahn MS, Lee KE, Kim HJ, Ahn HK, Kim HJ, Park KU, Park IH. Sci Rep. 2023 Jun 19; 2023 Jun 19. PMID: 37336919.
• NLRX1 knockdown attenuates pro-apoptotic signaling and cell death in pulmonary hyperoxic acute injury.Kim HR, Kim MN, Kim EG, Leem JS, Baek SM, Lee YJ, Kim KW, Kang MJ, Song TW, Sohn MH. Sci Rep. 2023 Mar 1; 2023 Mar 1. PMID: 36859435.
• Coronavirus Lung Infection Impairs Host Immunity against Secondary Bacterial Infection by Promoting Lysosomal Dysfunction.Peng X, Kim J, Gupta G, Agaronyan K, Mankowski MC, Korde A, Takyar SS, Shin HJ, Habet V, Voth S, Audia JP, Chang D, Liu X, Wang L, Cai Y, Tian X, Ishibe S, Kang MJ, Compton S, Wilen CB, Dela Cruz CS, Sharma L. J Immunol. 2022 Oct 1; 2022 Sep 2. PMID: 36165196.
• Epidermal Growth Factor Receptor Inhibition Is Protective in Hyperoxia-Induced Lung Injury.Harris ZM, Sun Y, Joerns J, Clark B, Hu B, Korde A, Sharma L, Shin HJ, Manning EP, Placek L, Unutmaz D, Stanley G, Chun H, Sauler M, Rajagopalan G, Zhang X, Kang MJ, Koff JL. Oxid Med Cell Longev. 2022; 2022 Sep 20. PMID: 36193076.
• Distinct Roles of Type I and Type III Interferons during a Native Murine β Coronavirus Lung Infection.Sharma L, Peng X, Qing H, Hilliard BK, Kim J, Swaminathan A, Tian J, Israni-Winger K, Zhang C, Habet V, Wang L, Gupta G, Tian X, Ma Y, Shin HJ, Kim SH, Kang MJ, Ishibe S, Young LH, Kotenko S, Compton S, Wilen CB, Wang A, Dela Cruz CS. J Virol. 2022 Jan 26; 2021 Oct 27. PMID: 34705554.
• Chitinase 3-like-1 is a therapeutic target that mediates the effects of aging in COVID-19.Kamle S, Ma B, He CH, Akosman B, Zhou Y, Lee CM, El-Deiry WS, Huntington K, Liang O, Machan JT, Kang MJ, Shin HJ, Mizoguchi E, Lee CG, Elias JA. JCI Insight. 2021 Nov 8; 2021 Nov 8. PMID: 34747367.
• Nucleotide-binding domain and leucine-rich-repeat-containing protein X1 deficiency induces nicotinamide adenine dinucleotide decline, mechanistic target of rapamycin activation, and cellular senescence and accelerates aging lung-like changes.Shin HJ, Kim SH, Park HJ, Shin MS, Kang I, Kang MJ. Aging Cell. 2021 Jul; 2021 Jun 4. PMID: 34087956.
• Macrophage-preferable delivery of the leucine-rich repeat domain of NLRX1 ameliorates lethal sepsis by regulating NF-κB and inflammasome signaling activation.Koo JH, Kim SH, Jeon SH, Kang MJ, Choi JM. Biomaterials. 2021 Jul; 2021 May 4. PMID: 33971559.
• PINK1 Inhibits Multimeric Aggregation and Signaling of MAVS and MAVS-Dependent Lung Pathology.Kim SH, Shin HJ, Yoon CM, Lee SW, Sharma L, Dela Cruz CS, Kang MJ. Am J Respir Cell Mol Biol. 2021 May. PMID: 33577398.
• Mitochondrial antiviral signaling protein is crucial for the development of pulmonary fibrosis.Kim SH, Lee JY, Yoon CM, Shin HJ, Lee SW, Rosas I, Herzog E, Dela Cruz CS, Kaminski N, Kang MJ. Eur Respir J. 2021 Apr; 2021 Apr 15. PMID: 33093124.
• Hospitalization increases while economic status deteriorates in late stages of chronic obstructive pulmonary disease: the Korean National Health and Nutrition Examination Survey for 2007-2015.Kang HK, Jung JW, Kang MJ, Kim DK, Choi H, Cho YJ, Jang SH, Lee CH, Oh YM, Park J, Kim JY. J Thorac Dis. 2021 Apr. PMID: 34012566.
• Smoking Alters Inflammation and Skeletal Stem and Progenitor Cell Activity During Fracture Healing in Different Murine Strains.Hao Z, Li J, Li B, Alder KD, Cahill SV, Munger AM, Lee I, Kwon HK, Back J, Xu S, Kang MJ, Lee FY. J Bone Miner Res. 2021 Jan; 2020 Sep 24. PMID: 32866293.
• Retrograde signaling by a mtDNA-encoded non-coding RNA preserves mitochondrial bioenergetics.Blumental-Perry A, Jobava R, Bederman I, Degar AJ, Kenche H, Guan BJ, Pandit K, Perry NA, Molyneaux ND, Wu J, Prendergas E, Ye ZW, Zhang J, Nelson CE, Ahangari F, Krokowski D, Guttentag SH, Linden PA, Townsend DM, Miron A, Kang MJ, Kaminski N, Perry Y, Hatzoglou M. Commun Biol. 2020 Oct 30; 2020 Oct 30. PMID: 33127975.
• Fecal microbial transplantation and a high fiber diet attenuates emphysema development by suppressing inflammation and apoptosis.Jang YO, Lee SH, Choi JJ, Kim DH, Choi JM, Kang MJ, Oh YM, Park YJ, Shin Y, Lee SW. Exp Mol Med. 2020 Jul; 2020 Jul 17. PMID: 32681029.
• Recent Advances in Molecular Basis of Lung Aging and Its Associated Diseases.Kang MJ. Tuberc Respir Dis (Seoul). 2020 Apr; 2020 Mar 10. PMID: 32185913.
• LRR domain of NLRX1 protein delivery by dNP2 inhibits T cell functions and alleviates autoimmune encephalomyelitis.Koo JH, Kim DH, Cha D, Kang MJ, Choi JM. Theranostics. 2020; 2020 Feb 10. PMID: 32194859.
• Impact of Cigarette Smoke Exposure on the Lung Fibroblastic Response after Influenza Pneumonia.Lee SW, Sharma L, Kang YA, Kim SH, Chandrasekharan S, Losier A, Brady V, Bermejo S, Andrews N, Yoon CM, Liu W, Lee JY, Kang MJ, Dela Cruz CS. Am J Respir Cell Mol Biol. 2018 Dec. PMID: 30110182.
• Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases.Dela Cruz CS, Kang MJ. Mitochondrion. 2018 Jul; 2017 Dec 6. PMID: 29221810.
• Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis.Kim DH, Park HJ, Lim S, Koo JH, Lee HG, Choi JO, Oh JH, Ha SJ, Kang MJ, Lee CM, Lee CG, Elias JA, Choi JM. Nat Commun. 2018 Feb 5; 2018 Feb 5. PMID: 29403003.
• A Mitochondrial Perspective of Chronic Obstructive Pulmonary Disease Pathogenesis.Kang MJ, Shadel GS. Tuberc Respir Dis (Seoul). 2016 Oct; 2016 Oct 5. PMID: 27790272.
• Mitochondrial Regulation of Inflammasome Activation in Chronic Obstructive Pulmonary Disease.Yoon CM, Nam M, Oh YM, Dela Cruz CS, Kang MJ. J Innate Immun. 2016; 2015 Nov 5. PMID: 26536345.
• Role of Chitinase 3-Like-1 in Interleukin-18-Induced Pulmonary Type 1, Type 2, and Type 17 Inflammation; Alveolar Destruction; and Airway Fibrosis in the Murine Lung.Kang MJ, Yoon CM, Nam M, Kim DH, Choi JM, Lee CG, Elias JA. Am J Respir Cell Mol Biol. 2015 Dec. PMID: 25955511.
• MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury.Mannam P, Shinn AS, Srivastava A, Neamu RF, Walker WE, Bohanon M, Merkel J, Kang MJ, Dela Cruz CS, Ahasic AM, Pisani MA, Trentalange M, West AP, Shadel GS, Elias JA, Lee PJ. Am J Physiol Lung Cell Mol Physiol. 2014 Apr 1; 2014 Jan 31. PMID: 24487387.
• Role of ribonuclease L in viral pathogen-associated molecular pattern/influenza virus and cigarette smoke-induced inflammation and remodeling.Zhou Y, Kang MJ, Jha BK, Silverman RH, Lee CG, Elias JA. J Immunol. 2013 Sep 1; 2013 Aug 2. PMID: 23913960.
• IL-13 receptor α2-arginase 2 pathway mediates IL-13-induced pulmonary hypertension.Cho WK, Lee CM, Kang MJ, Huang Y, Giordano FJ, Lee PJ, Trow TK, Homer RJ, Sessa WC, Elias JA, Lee CG. Am J Physiol Lung Cell Mol Physiol. 2013 Jan 15; 2012 Nov 2. PMID: 23125252.
• Amphiregulin, an epidermal growth factor receptor ligand, plays an essential role in the pathogenesis of transforming growth factor-β-induced pulmonary fibrosis.Zhou Y, Lee JY, Lee CM, Cho WK, Kang MJ, Koff JL, Yoon PO, Chae J, Park HO, Elias JA, Lee CG. J Biol Chem. 2012 Dec 7; 2012 Oct 19. PMID: 23086930.
• IL-18 induces emphysema and airway and vascular remodeling via IFN-γ, IL-17A, and IL-13.Kang MJ, Choi JM, Kim BH, Lee CM, Cho WK, Choe G, Kim DH, Lee CG, Elias JA. Am J Respir Crit Care Med. 2012 Jun 1; 2012 Mar 1. PMID: 22383501.
• Role of breast regression protein-39 in the pathogenesis of cigarette smoke-induced inflammation and emphysema.Matsuura H, Hartl D, Kang MJ, Dela Cruz CS, Koller B, Chupp GL, Homer RJ, Zhou Y, Cho WK, Elias JA, Lee CG. Am J Respir Cell Mol Biol. 2011 Jun; 2010 Jul 23. PMID: 20656949.
• RIG-like helicase innate immunity inhibits vascular endothelial growth factor tissue responses via a type I IFN-dependent mechanism.Ma B, Dela Cruz CS, Hartl D, Kang MJ, Takyar S, Homer RJ, Lee CG, Elias JA. Am J Respir Crit Care Med. 2011 May 15; 2011 Jan 28. PMID: 21278304.
• Transgenic modelling of cytokine polarization in the lung.Dela Cruz CS, Kang MJ, Cho WK, Lee CG. Immunology. 2011 Jan; 2010 Nov 23. PMID: 21091906.
• Role of chitin and chitinase/chitinase-like proteins in inflammation, tissue remodeling, and injury.Lee CG, Da Silva CA, Dela Cruz CS, Ahangari F, Ma B, Kang MJ, He CH, Takyar S, Elias JA. Annu Rev Physiol. 2011. PMID: 21054166.
• Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice.Kang MJ, Lee CG, Lee JY, Dela Cruz CS, Chen ZJ, Enelow R, Elias JA. J Clin Invest. 2008 Aug. PMID: 18654661.
• IL-18 is induced and IL-18 receptor alpha plays a critical role in the pathogenesis of cigarette smoke-induced pulmonary emphysema and inflammation.Kang MJ, Homer RJ, Gallo A, Lee CG, Crothers KA, Cho SJ, Rochester C, Cain H, Chupp G, Yoon HJ, Elias JA. J Immunol. 2007 Feb 1. PMID: 17237446.
• IFN-gamma-dependent DNA injury and/or apoptosis are critical in cigarette smoke-induced murine emphysema.Kang MJ, Lee CG, Cho SJ, Homer RJ, Elias JA. Proc Am Thorac Soc. 2006 Aug. PMID: 16921135.
• State of the art. Mechanistic heterogeneity in chronic obstructive pulmonary disease: insights from transgenic mice.Elias JA, Kang MJ, Crothers K, Homer R, Lee CG. Proc Am Thorac Soc. 2006 Aug. PMID: 16921126.
• Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling.Cho SJ, Kang MJ, Homer RJ, Kang HR, Zhang X, Lee PJ, Elias JA, Lee CG. J Biol Chem. 2006 Mar 24; 2006 Jan 26. PMID: 16439363.
• Role of CCR5 in IFN-gamma-induced and cigarette smoke-induced emphysema.Ma B, Kang MJ, Lee CG, Chapoval S, Liu W, Chen Q, Coyle AJ, Lora JM, Picarella D, Homer RJ, Elias JA. J Clin Invest. 2005 Dec; 2005 Nov 10. PMID: 16284650.
• Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema.Zheng T, Kang MJ, Crothers K, Zhu Z, Liu W, Lee CG, Rabach LA, Chapman HA, Homer RJ, Aldous D, De Sanctis GT, Underwood S, Graupe M, Flavell RA, Schmidt JA, Elias JA. J Immunol. 2005 Jun 15. PMID: 15944319.
• Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung.Lee CG, Link H, Baluk P, Homer RJ, Chapoval S, Bhandari V, Kang MJ, Cohn L, Kim YK, McDonald DM, Elias JA. Nat Med. 2004 Oct; 2004 Sep 19. PMID: 15378055.
• Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis.Lee CG, Cho SJ, Kang MJ, Chapoval SP, Lee PJ, Noble PW, Yehualaeshet T, Lu B, Flavell RA, Milbrandt J, Homer RJ, Elias JA. J Exp Med. 2004 Aug 2. PMID: 15289506.