2021
MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease
Nouws J, Wan F, Finnemore E, Roque W, Kim SJ, Bazan IS, Li CX, Sköld C, Dai Q, Yan X, Chioccioli M, Neumeister V, Britto CJ, Sweasy J, Bindra RS, Wheelock ÅM, Gomez JL, Kaminski N, Lee PJ, Sauler M. MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease. JCI Insight 2021, 6: e134218. PMID: 33290275, PMCID: PMC7934877, DOI: 10.1172/jci.insight.134218.Peer-Reviewed Original ResearchConceptsCellular stress responseStress responseHomology-directed DNA repairDNA damage responseProtein BRCA1Damage responseCellular stressDNA repairProtein BimCOPD lung tissueLung epithelial cellsCellular responsesExpression arraysEpithelial cell apoptosisDNA damageChronic obstructive pulmonary diseaseBRCA1 expressionCell apoptosisApoptosisEpithelial cellsCritical mechanismMicroRNAsRegulatorObstructive pulmonary diseaseIncreases Susceptibility
2008
Progressive recruitment of Runx2 to genomic targets despite decreasing expression during osteoblast differentiation
Pregizer S, Baniwal SK, Yan X, Borok Z, Frenkel B. Progressive recruitment of Runx2 to genomic targets despite decreasing expression during osteoblast differentiation. Journal Of Cellular Biochemistry 2008, 105: 965-970. PMID: 18821584, PMCID: PMC2591066, DOI: 10.1002/jcb.21900.Peer-Reviewed Original ResearchConceptsOC promoterGenomic targetsOsteoblast differentiationNovel genomic targetsChIP-chip analysisChromatin immunoprecipitation assaysDNA-binding abilityDNA-binding activityOsteoblast transcription factorSuch stringent controlTranscriptional controlMRNA levelsTranslational controlTranscription factorsImmunoprecipitation assaysMC3T3-E1 culturesRunx2 mRNA levelsOC mRNA levelsOsteoblast phenotypeRunx2 mRNAPromoterRunx2Protein amountOC expressionStringent control