Use of Bayesian networks to dissect the complexity of genetic disease: application to the Genetic Analysis Workshop 17 simulated data
Kang J, Zheng W, Li L, Lee JS, Yan X, Zhao H. Use of Bayesian networks to dissect the complexity of genetic disease: application to the Genetic Analysis Workshop 17 simulated data. BMC Proceedings 2011, 5: s37. PMID: 22373110, PMCID: PMC3287873, DOI: 10.1186/1753-6561-5-s9-s37.Peer-Reviewed Original ResearchCollapsing-based and kernel-based single-gene analyses applied to Genetic Analysis Workshop 17 mini-exome data
Li L, Zheng W, Lee JS, Zhang X, Ferguson J, Yan X, Zhao H. Collapsing-based and kernel-based single-gene analyses applied to Genetic Analysis Workshop 17 mini-exome data. BMC Proceedings 2011, 5: s117. PMID: 22373309, PMCID: PMC3287841, DOI: 10.1186/1753-6561-5-s9-s117.Peer-Reviewed Original ResearchMinor allele frequencyCausal variantsGenetic Analysis Workshop 17 mini-exome dataSingle gene analysisLow minor allele frequencyGAW17 data setRare variantsFalse positive genesFunctional annotationPhenotypic varianceTop genesGenotypic dataNoncausal variantsAssociation dataGenetic effectsAssociation TestUnrelated individualsAllele frequenciesGenesSame genotype distributionBayesian mixed-effects modelsVariantsSimilar genotype distributionGAW17Traits