2022
FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis
Preisendörfer S, Ishikawa Y, Hennen E, Winklmeier S, Schupp JC, Knüppel L, Fernandez IE, Binzenhöfer L, Flatley A, Juan-Guardela BM, Ruppert C, Guenther A, Frankenberger M, Hatz RA, Kneidinger N, Behr J, Feederle R, Schepers A, Hilgendorff A, Kaminski N, Meinl E, Bächinger HP, Eickelberg O, Staab-Weijnitz CA. FK506-Binding Protein 11 Is a Novel Plasma Cell-Specific Antibody Folding Catalyst with Increased Expression in Idiopathic Pulmonary Fibrosis. Cells 2022, 11: 1341. PMID: 35456020, PMCID: PMC9027113, DOI: 10.3390/cells11081341.Peer-Reviewed Original ResearchMeSH KeywordsHumansIdiopathic Pulmonary FibrosisImmunoglobulin GPeptidylprolyl IsomerasePlasma CellsTacrolimus Binding ProteinsConceptsIdiopathic pulmonary fibrosisPlasma cellsPulmonary fibrosisIgG antibodiesFatal chronic lung diseaseCell linesAntibody-producing plasma cellsChronic lung diseaseAdaptive immune responsesHybridoma cell linesAlveolar epithelial cell lineCell-specific antibodiesCell deathAntibody-producing hybridoma cellsAutoimmune featuresX-box-binding protein 1IPF lungsLung diseaseEpithelial cell lineImmune responseLymphatic tissueB cellsStress-mediated cell deathAntibody secretionER stress-mediated cell death
2013
Patients with Idiopathic Pulmonary Fibrosis with Antibodies to Heat Shock Protein 70 Have Poor Prognoses
Kahloon RA, Xue J, Bhargava A, Csizmadia E, Otterbein L, Kass DJ, Bon J, Soejima M, Levesque MC, Lindell KO, Gibson KF, Kaminski N, Banga G, Oddis CV, Pilewski JM, Sciurba FC, Donahoe M, Zhang Y, Duncan SR. Patients with Idiopathic Pulmonary Fibrosis with Antibodies to Heat Shock Protein 70 Have Poor Prognoses. American Journal Of Respiratory And Critical Care Medicine 2013, 187: 768-775. PMID: 23262513, PMCID: PMC3678112, DOI: 10.1164/rccm.201203-0506oc.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisAnti-HSP70 autoantibodiesPulmonary fibrosisAntigen-specific immune responsesAntigen-specific immunoassaysLung function deteriorationCD4 T cellsInterstitial lung diseaseIL-4 productionIL-8 productionUseful clinical informationHeat shock protein 70Acute exacerbationDiverse autoantibodiesIPF cohortIPF outcomesShock protein 70Function deteriorationMost patientsSpecific autoantibodiesIPF lungsIgG autoantibodiesClinical progressionPoor prognosisIPF progression
2007
Cellular and Humoral Autoreactivity in Idiopathic Pulmonary Fibrosis
Feghali-Bostwick CA, Tsai CG, Valentine VG, Kantrow S, Stoner MW, Pilewski JM, Gadgil A, George MP, Gibson KF, Choi AM, Kaminski N, Zhang Y, Duncan SR. Cellular and Humoral Autoreactivity in Idiopathic Pulmonary Fibrosis. The Journal Of Immunology 2007, 179: 2592-2599. PMID: 17675522, DOI: 10.4049/jimmunol.179.4.2592.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisCD4 T cellsT cellsIPF patientsAutoantibody productionPulmonary fibrosisEffector functionsProliferative responseAutologous CD4 T cellsLung extractsPeripheral CD4 T lymphocytesPeripheral CD4 T cellsT cell clonal expansionAutoreactive immune processesAdaptive immune mechanismsCD4 T lymphocytesMHC class IIMore effective therapiesCell clonal expansionCycles of stimulationHumoral autoreactivityOligoclonal expansionPathologic responseIL-10Hilar lymph