Engraftment and differentiation of human metanephroi into functional mature nephrons after transplantation into mice is accompanied by a profile of gene expression similar to normal human kidney development.
Dekel B, Amariglio N, Kaminski N, Schwartz A, Goshen E, Arditti FD, Tsarfaty I, Passwell JH, Reisner Y, Rechavi G. Engraftment and differentiation of human metanephroi into functional mature nephrons after transplantation into mice is accompanied by a profile of gene expression similar to normal human kidney development. Journal Of The American Society Of Nephrology 2002, 13: 977-990. PMID: 11912257, DOI: 10.1681/asn.v134977.Peer-Reviewed Original ResearchConceptsHuman kidney developmentKidney developmentNormal human kidney developmentSpecific genesGene expressionGlobal gene expression patternsGlobal gene expressionMature nephronsGene expression patternsCell cycle regulatorsExtracellular matrix moleculesResult of hybridizationMolecular regulationCDNA arraysEmbryonic precursorsExpression patternsCycle regulatorsExpression profilesGenesMatrix moleculesExpression levelsAdult kidneyGrowth factorMetanephroiDevelopment of strategies