2006
Multiple Imprinted and Stemness Genes Provide a Link between Normal and Tumor Progenitor Cells of the Developing Human Kidney
Dekel B, Metsuyanim S, Schmidt-Ott KM, Fridman E, Jacob-Hirsch J, Simon A, Pinthus J, Mor Y, Barasch J, Amariglio N, Reisner Y, Kaminski N, Rechavi G. Multiple Imprinted and Stemness Genes Provide a Link between Normal and Tumor Progenitor Cells of the Developing Human Kidney. Cancer Research 2006, 66: 6040-6049. PMID: 16778176, DOI: 10.1158/0008-5472.can-05-4528.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGene Expression ProfilingGenomic ImprintingHomeodomain ProteinsHumansKidneyKidney NeoplasmsMiceMice, Inbred BALB CMice, NudeMice, SCIDMultigene FamilyMyeloid Ecotropic Viral Integration Site 1 ProteinNeoplasm ProteinsNeoplasm TransplantationNeoplastic Stem CellsOligonucleotide Array Sequence AnalysisRatsTransplantation, HeterologousWilms TumorConceptsProgenitor cell populationsRenal progenitor cell populationStemness genesCell populationsNormal kidney developmentAdult mouse kidneyHomeobox genesMetanephric blastemaExpression of Peg3Transcriptional profilingOligonucleotide microarraysKidney developmentDifferentiated cellsCell differentiationHuman fetal kidneyTumor progenitor cellsGenesReal-time PCRMouse nephrogenesisBlastemaWT samplesProgenitor cellsStromal phenotypeWT sourcesPeg3
2002
Engraftment and differentiation of human metanephroi into functional mature nephrons after transplantation into mice is accompanied by a profile of gene expression similar to normal human kidney development.
Dekel B, Amariglio N, Kaminski N, Schwartz A, Goshen E, Arditti FD, Tsarfaty I, Passwell JH, Reisner Y, Rechavi G. Engraftment and differentiation of human metanephroi into functional mature nephrons after transplantation into mice is accompanied by a profile of gene expression similar to normal human kidney development. Journal Of The American Society Of Nephrology 2002, 13: 977-990. PMID: 11912257, DOI: 10.1681/asn.v134977.Peer-Reviewed Original ResearchConceptsHuman kidney developmentKidney developmentNormal human kidney developmentSpecific genesGene expressionGlobal gene expression patternsGlobal gene expressionMature nephronsGene expression patternsCell cycle regulatorsExtracellular matrix moleculesResult of hybridizationMolecular regulationCDNA arraysEmbryonic precursorsExpression patternsCycle regulatorsExpression profilesGenesMatrix moleculesExpression levelsAdult kidneyGrowth factorMetanephroiDevelopment of strategies