Featured Publications
Endothelial CD74 mediates macrophage migration inhibitory factor protection in hyperoxic lung injury
Sauler M, Zhang Y, Min J, Leng L, Shan P, Roberts S, Jorgensen WL, Bucala R, Lee PJ. Endothelial CD74 mediates macrophage migration inhibitory factor protection in hyperoxic lung injury. The FASEB Journal 2015, 29: 1940-1949. PMID: 25609432, PMCID: PMC4415022, DOI: 10.1096/fj.14-260299.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorLung endothelial cellsMurine lung endothelial cellsLung injuryEndothelial cellsProtective effectExogenous MIFCD74 deficient miceCD74-dependent mannerHours of hyperoxiaMIF receptor CD74Acute lung injuryHyperoxic lung injuryBronchoalveolar lavage proteinMigration inhibitory factorBronchoalveolar proteinMIF deficiencyMedian survivalEndothelial injuryWT miceAcute oxidative stressReceptor CD74Lavage proteinReceptor antagonistReceptor inhibitors
2016
D‐dopachrome tautomerase in adipose tissue inflammation and wound repair
Kim B, Tilstam PV, Hwang SS, Simons D, Schulte W, Leng L, Sauler M, Ganse B, Averdunk L, Kopp R, Stoppe C, Bernhagen J, Pallua N, Bucala R. D‐dopachrome tautomerase in adipose tissue inflammation and wound repair. Journal Of Cellular And Molecular Medicine 2016, 21: 35-45. PMID: 27605340, PMCID: PMC5192814, DOI: 10.1111/jcmm.12936.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAnimalsAntigens, Differentiation, B-LymphocyteCell MovementCell ProliferationDown-RegulationFibroblastsHistocompatibility Antigens Class IIHumansInflammationIntramolecular OxidoreductasesMacrophagesMaleMiceMice, Inbred C57BLObesityReceptors, CXCR4Receptors, Interleukin-8BUp-RegulationWound HealingConceptsAdipose tissue inflammationSubcutaneous adipose tissueD-DTAdipose tissueTissue inflammationWound repairEpididymal fat padsDopachrome tautomeraseReceptor CXCR2MIF antibodyInflammatory cellsReceptor CD74Healthy donorsReceptor expressionFat padMRNA expressionProtein levelsWound healingFibroblast survivalMIFInflammationHealingTissueCell migrationFibroblast wound healing