2020
Form, Function, and Dysfunction: Airway Diseases Are Associated With Increased Risk for Rheumatoid Arthritis
Sauler M. Form, Function, and Dysfunction: Airway Diseases Are Associated With Increased Risk for Rheumatoid Arthritis. Arthritis & Rheumatology 2020, 72: 699-701. PMID: 31876099, PMCID: PMC7188593, DOI: 10.1002/art.41193.Commentaries, Editorials and LettersMeSH KeywordsArthritis, RheumatoidAsthmaFemaleHumansProspective StudiesPulmonary Disease, Chronic Obstructive
2016
MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis
Yoo SA, Leng L, Kim BJ, Du X, Tilstam PV, Kim KH, Kong JS, Yoon HJ, Liu A, Wang T, Song Y, Sauler M, Bernhagen J, Ritchlin CT, Lee P, Cho CS, Kim WU, Bucala R. MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: e7917-e7926. PMID: 27872288, PMCID: PMC5150393, DOI: 10.1073/pnas.1612717113.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorHigh-expression MIF allelesJoint destructionRheumatoid arthritisMIF allelesProgressive joint destructionInvasive phenotypeFibroblast-like synoviocytesMigration inhibitory factorJoint erosionsMIF receptorAutoimmune responseMIF pathwaySynovial fibroblastsCell surface CD74Autocrine pathwayCD44 expressionInhibitory factorPharmacologic inhibitionTumor invasionArthritisInvasive propertiesCD44 receptorCD44Receptor complexTranscription factor ICBP90 regulates the MIF promoter and immune susceptibility locus
Yao J, Leng L, Sauler M, Fu W, Zheng J, Zhang Y, Du X, Yu X, Lee P, Bucala R. Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus. Journal Of Clinical Investigation 2016, 126: 732-744. PMID: 26752645, PMCID: PMC4731159, DOI: 10.1172/jci81937.Peer-Reviewed Original ResearchMeSH KeywordsArthritis, RheumatoidCCAAT-Enhancer-Binding ProteinsGenetic LociGenetic Predisposition to DiseaseHumansIntramolecular OxidoreductasesJurkat CellsMacrophage Migration-Inhibitory FactorsMicrosatellite RepeatsPolymorphism, GeneticPromoter Regions, GeneticTranscription, GeneticUbiquitin-Protein LigasesConceptsTranscription factorsMacrophage migration inhibitory factorWhole-genome transcription analysisOligonucleotide affinity chromatographyLength-dependent mannerTranscriptional regulationFunctional insightsTranscription analysisNuclear proteinsImmune response genesPolymorphic lociMIF promoterResponse genesNuclear lysatesKey regulatorHigher mRNA levelsMajor proteinsSusceptibility lociTranscriptionCytokine macrophage migration inhibitory factorLociExpression levelsCommon allelesMigration inhibitory factorMicrosatellite polymorphism