2024
Studying the Pulmonary Endothelium in Health and Disease: An Official American Thoracic Society Workshop Report
Hough R, Alvira C, Bastarache J, Erzurum S, Kuebler W, Schmidt E, Shimoda L, Abman S, Alvarez D, Belvitch P, Bhattacharya J, Birukov K, Chan S, Cornfield D, Dudek S, Garcia J, Harrington E, Hsia C, Islam M, Jonigk D, Kalinichenko V, Kolb T, Lee J, Mammoto A, Mehta D, Rounds S, Schupp J, Shaver C, Suresh K, Tambe D, Ventetuolo C, Yoder M, Stevens T, Damarla M. Studying the Pulmonary Endothelium in Health and Disease: An Official American Thoracic Society Workshop Report. American Journal Of Respiratory Cell And Molecular Biology 2024, 71: 388-406. PMID: 39189891, PMCID: PMC11450313, DOI: 10.1165/rcmb.2024-0330st.Peer-Reviewed Original ResearchVascular diseaseEndothelial cell injuryAmerican Thoracic SocietyEndothelial cell functionPulmonary endotheliumMechanical propertiesLung endotheliumChronic vascular diseaseEndothelial functionPathophysiological mechanismsHealth and DiseaseVascular locationThoracic SocietyCell injuryEndotheliumCell functionTissue compartmentsDiseaseVascular circuitBidirectional signalingTranslation of discoveriesBlood
2023
Effects of sotatercept on lung diffusion capacity and blood gases in patients with pulmonary arterial hypertension
Olsson K, Fuge J, Park D, Kamp J, Brod T, Harrigfeld B, Schupp J, Hoeper M. Effects of sotatercept on lung diffusion capacity and blood gases in patients with pulmonary arterial hypertension. European Respiratory Journal 2023, 62: 2301070. PMID: 37474157, DOI: 10.1183/13993003.01070-2023.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionLung diffusion capacityArterial hypertensionDiffusion capacityRight heart functionRight ventricular afterloadSmall pulmonary vesselsVentricular afterloadBlood gasesPulmonary vesselsHeart functionRare diseaseHypertensionPatientsSotaterceptProgressive increaseSymptomsVariable alterationsDisease symptomsGas exchangeAfterloadDiseaseSeverity
2021
A Pulmonary Vascular Model From Endothelialized Whole Organ Scaffolds
Yuan Y, Leiby KL, Greaney AM, Raredon MSB, Qian H, Schupp JC, Engler AJ, Baevova P, Adams TS, Kural MH, Wang J, Obata T, Yoder MC, Kaminski N, Niklason LE. A Pulmonary Vascular Model From Endothelialized Whole Organ Scaffolds. Frontiers In Bioengineering And Biotechnology 2021, 9: 760309. PMID: 34869270, PMCID: PMC8640093, DOI: 10.3389/fbioe.2021.760309.Peer-Reviewed Original ResearchVascular diseaseEndothelial phenotypeLung vascular diseaseAcute lung injuryPulmonary microvascular functionWhole lung scaffoldsVascular barrier functionLung injuryMicrovascular functionEndothelial cell coverageSingle-cell RNA-sequencing analysisLPS treatmentProinflammatory signalsWhole lungLung endotheliumLung systemVascular barrierOrgan engineering approachesBarrier functionLungWhole-organ scaffoldsVascular structuresDrug mechanismsEndotheliumDiseaseAbnormal FeV1 and body mass index are associated with impaired cough-related quality of life in sarcoidosis patients
Frye B, Potasso L, Farin E, Fichtner U, Birring S, Müller-Quernheim J, Schupp J. Abnormal FeV1 and body mass index are associated with impaired cough-related quality of life in sarcoidosis patients. Respiratory Medicine 2021, 188: 106600. PMID: 34530353, DOI: 10.1016/j.rmed.2021.106600.Peer-Reviewed Original ResearchConceptsLeicester Cough QuestionnaireCough-related qualityQuality of lifeSarcoidosis patientsLCQ scoreBody mass indexAbnormal FEV1Routine followLung functionOrgan impairmentTreatable traitsMass indexDisease burdenGranulomatous diseaseFEV1PatientsSarcoidosisBMIScoresQuestionnaireLungCohortFollowDiseaseLife
2017
Transcriptome profiles in sarcoidosis and their potential role in disease prediction
Schupp JC, Vukmirovic M, Kaminski N, Prasse A. Transcriptome profiles in sarcoidosis and their potential role in disease prediction. Current Opinion In Pulmonary Medicine 2017, 23: 487-492. PMID: 28590292, PMCID: PMC5637542, DOI: 10.1097/mcp.0000000000000403.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGenome-wide expression studiesWide expression studiesTranscriptome profilesTranscriptomic dataRNA sequencingExpression studiesGene expressionMolecular mechanismsLarge prospective followTh1 immune responseTranscriptomeNonnecrotizing granulomasProspective followSystemic diseaseDisease progressionTreatment outcomesImmune responseSarcoidosisPotential roleControl tissuesProgressive sarcoidosisKey roleDiseaseTranscriptomicsGranulomas
2015
Diagnostik und Therapie der Sarkoidose
Frye B, Schupp J, Köhler T, Müller-Quernheim J. Diagnostik und Therapie der Sarkoidose. Der Internist 2015, 56: 1346-1352. PMID: 26563335, DOI: 10.1007/s00108-015-3757-1.ChaptersConceptsIntrathoracic lymph nodesLymph nodesGranulomatous diseaseSteroid-refractory diseaseFurther therapeutic optionsNon-necrotizing granulomasDiagnostik und TherapieLung transplantationSarcoidosis treatmentSteroid therapyCNS involvementStarting doseSymptomatic therapyOrgan impairmentTherapeutic optionsUnd TherapieEndobronchial ultrasoundSpontaneous resolutionBody weightSarcoidosisOrphan diseaseMonoclonal antibodiesDiseaseSymptomatic patternGranulomas