Inhaled Vasoactive Intestinal Peptide Exerts Immunoregulatory Effects in Sarcoidosis
Prasse A, Zissel G, Lützen N, Schupp J, Schmiedlin R, Gonzalez-Rey E, Rensing-Ehl A, Bacher G, Cavalli V, Bevec D, Delgado M, Müller-Quernheim J. Inhaled Vasoactive Intestinal Peptide Exerts Immunoregulatory Effects in Sarcoidosis. American Journal Of Respiratory And Critical Care Medicine 2010, 182: 540-548. PMID: 20442436, DOI: 10.1164/rccm.200909-1451oc.Peer-Reviewed Original ResearchConceptsVasoactive intestinal peptideRegulatory T cellsT cellsImmunoregulatory effectsImmunoregulatory roleLung disordersVIP treatmentCapacity of VIPChronic inflammatory lung disordersPeripheral regulatory T cellsTumor necrosis factor-alpha productionClinical phase II studyNecrosis factor-alpha productionConventional effector T cellsEpitheloid cell granulomasFatal organ dysfunctionPhase II studyEffector T cellsExaggerated immune responseChronic lung inflammationInflammatory lung disordersBronchoalveolar lavage fluidNew therapeutic principleImportant immunoregulatory roleActive disease