2024
Long-term exposure to wildland fire smoke PM2.5 and mortality in the contiguous United States
Ma Y, Zang E, Liu Y, Wei J, Lu Y, Krumholz H, Bell M, Chen K. Long-term exposure to wildland fire smoke PM2.5 and mortality in the contiguous United States. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2403960121. PMID: 39316057, PMCID: PMC11459178, DOI: 10.1073/pnas.2403960121.Peer-Reviewed Original ResearchConceptsWildland firesContiguous United StatesNonaccidental mortalityExposure to ambient fine particlesSmoke PM<sWildland fire smokeMoving average concentrationsAmbient fine particlesLong-term exposureAverage concentrationSmoke PMHealth risksFine particlesFire smokeTemporal confoundingHealth effectsKidney disease mortalityChronic kidney disease mortalityPublic health actionFireMortality rateUnited StatesDisease mortalityHealth actionsMortality outcomesAir pollution changes due to COVID-19 lockdowns and attributable mortality changes in four countries
Ma Y, Nobile F, Marb A, Dubrow R, Kinney P, Peters A, Stafoggia M, Breitner S, Chen K. Air pollution changes due to COVID-19 lockdowns and attributable mortality changes in four countries. Environment International 2024, 187: 108668. PMID: 38640613, DOI: 10.1016/j.envint.2024.108668.Peer-Reviewed Original ResearchConceptsMeteorological normalization techniqueAir pollution changesFine particulate matterImprove air qualityEmission control strategiesCentral-southern ItalyPollution changesParticulate matterRegion-specific estimatesAir qualityMeteorological impactsAir pollutionPollutionCOVID-19 lockdownModeling approachAirCaliforniaMortality changesConcentrationJiangsuEmissionTime trendsLocal characteristicsChinaMatterShort-Term Exposure to Fine Particulate Matter and Nitrogen Dioxide and Mortality in 4 Countries
Ma Y, Nobile F, Marb A, Dubrow R, Stafoggia M, Breitner S, Kinney P, Chen K. Short-Term Exposure to Fine Particulate Matter and Nitrogen Dioxide and Mortality in 4 Countries. JAMA Network Open 2024, 7: e2354607. PMID: 38427355, PMCID: PMC10907920, DOI: 10.1001/jamanetworkopen.2023.54607.Peer-Reviewed Original ResearchConceptsShort-term exposure to air pollutionExposure to air pollutionFine particulate matterCross-sectional studyAir pollutionFixed-effects modelParticulate matterShort-term exposure to PM2.5Short-term exposure to fine particulate matterNO2 concentrationsExposure to fine particulate matterMortality rateNitrogen dioxideSignificant effect modificationDaily PM2.5 concentrationsTime-varying confoundersExposure to PM2.5Health outcomesEstimate associationsMortality dataEffect modificationPM2.5 concentrationsMain OutcomesDay-to-dayCentral-southern Italy
2023
Floods and Diarrhea Risk in Young Children in Low- and Middle-Income Countries
Wang P, Asare E, Pitzer V, Dubrow R, Chen K. Floods and Diarrhea Risk in Young Children in Low- and Middle-Income Countries. JAMA Pediatrics 2023, 177: 1206-1214. PMID: 37782513, PMCID: PMC10546297, DOI: 10.1001/jamapediatrics.2023.3964.Peer-Reviewed Original ResearchConceptsMiddle-income countriesDiarrhea riskOdds ratioMAIN OUTCOMEMixed-effects logistic regression modelRisk of diarrheaCross-sectional studyHigher odds ratioPrevalence of diarrheaLogistic regression modelsHealth survey programUnexposed childrenEffect modificationChild healthDiarrhea prevalenceSurvey clustersSignificant associationHygiene practicesFourth weekWeeksStrong associationRandom interceptYoung childrenChildrenDiarrheaLong-Term Exposure to Fine Particulate Matter and Academic Performance Among Children in North Carolina
Lam P, Zang E, Chen D, Liu R, Chen K. Long-Term Exposure to Fine Particulate Matter and Academic Performance Among Children in North Carolina. JAMA Network Open 2023, 6: e2340928. PMID: 37906198, PMCID: PMC10618843, DOI: 10.1001/jamanetworkopen.2023.40928.Peer-Reviewed Original ResearchRacial/ethnic disparities in PM2.5-attributable cardiovascular mortality burden in the United States
Ma Y, Zang E, Opara I, Lu Y, Krumholz H, Chen K. Racial/ethnic disparities in PM2.5-attributable cardiovascular mortality burden in the United States. Nature Human Behaviour 2023, 7: 2074-2083. PMID: 37653149, PMCID: PMC10901568, DOI: 10.1038/s41562-023-01694-7.Peer-Reviewed Original ResearchConceptsNon-Hispanic White peopleCVD deathMortality burdenNon-Hispanic black peopleCardiovascular disease mortality ratesDisease mortality ratesNon-Hispanic blacksRace/ethnicityMortality rateLong-term exposureWhite peopleEthnic disparitiesHealth benefitsHispanic peopleSignificant differencesBurdenDeathUS countiesEthnic groupsAbsolute disparityAssociationExposureEthnic minoritiesDisparitiesAmbient fine particulate matter (PM2.5) concentrationsFuture temperature-related excess mortality under climate change and population aging scenarios in Canada
Hebbern C, Gosselin P, Chen K, Chen H, Cakmak S, MacDonald M, Chagnon J, Dion P, Martel L, Lavigne E. Future temperature-related excess mortality under climate change and population aging scenarios in Canada. Canadian Journal Of Public Health 2023, 114: 726-736. PMID: 37308698, PMCID: PMC10484859, DOI: 10.17269/s41997-023-00782-5.Peer-Reviewed Original ResearchConceptsPopulation aging scenariosExcess mortalityCoupled Model Inter-comparison Project 6Non-accidental mortalityDemographic changesShared Socioeconomic PathwaysNon-accidental deathsClimate change scenariosTemperature-related mortalityHealth regionsRural areasEstimate associationsCold-related mortalityAging scenariosPopulation growthMortality riskScenarios of population growthSustainable developmentChange scenariosMitigate future climate change impactsGreenhouse gas emission scenariosNet differenceClimate model ensembleEmission climate change scenarioClimate change impactsAssessment of Regional Nursing Home Preparedness for and Regulatory Responsiveness to Wildfire Risk in the Western US
Festa N, Throgmorton K, Davis-Plourde K, Dosa D, Chen K, Zang E, Kelly J, Gill T. Assessment of Regional Nursing Home Preparedness for and Regulatory Responsiveness to Wildfire Risk in the Western US. JAMA Network Open 2023, 6: e2320207. PMID: 37358851, PMCID: PMC10293909, DOI: 10.1001/jamanetworkopen.2023.20207.Peer-Reviewed Original ResearchConceptsCross-sectional studyNursing homesNursing home characteristicsMean survival timeUS nursing homesGreater mean numberPrimary outcomeUS CentersExposure statusMAIN OUTCOMEElevated riskSurvival timeSurvival analysisPresence of deficienciesMore deficienciesRisk statusEmergency preparednessHome characteristicsMean numberRiskPreparedness standardsDeficiencyResponsivenessHigh percentageOutcomesAssociations between short-term exposure to PM2.5, NO2 and O3 pollution and kidney-related conditions and the role of temperature-adjustment specification: A case-crossover study in New York state
Chu L, Chen K, Di Q, Crowley S, Dubrow R. Associations between short-term exposure to PM2.5, NO2 and O3 pollution and kidney-related conditions and the role of temperature-adjustment specification: A case-crossover study in New York state. Environmental Pollution 2023, 328: 121629. PMID: 37054868, DOI: 10.1016/j.envpol.2023.121629.Peer-Reviewed Original ResearchAssociations between short-term temperature exposure and kidney-related conditions in New York State: The influence of temperature metrics across four dimensions
Chu L, Chen K, Crowley S, Dubrow R. Associations between short-term temperature exposure and kidney-related conditions in New York State: The influence of temperature metrics across four dimensions. Environment International 2023, 173: 107783. PMID: 36841184, DOI: 10.1016/j.envint.2023.107783.Peer-Reviewed Original Research
2022
High-resolution spatiotemporal modeling of daily near-surface air temperature in Germany over the period 2000–2020
Nikolaou N, Dallavalle M, Stafoggia M, Bouwer L, Peters A, Chen K, Wolf K, Schneider A. High-resolution spatiotemporal modeling of daily near-surface air temperature in Germany over the period 2000–2020. Environmental Research 2022, 219: 115062. PMID: 36535393, DOI: 10.1016/j.envres.2022.115062.Peer-Reviewed Original ResearchConceptsLand surface temperatureSatellite-based land surface temperatureNear-surface air temperatureAir temperatureStation TSurface temperatureMulti-stage modelingTemperatureLow errorHigh resolutionSpatiotemporal coverageHigh accuracyBetter performanceSpatial variabilityWeather stationsModelingSecond stageSpatiotemporal modelingFirst stageMaximum TSpatiotemporal variabilitySubFuture temperature-related mortality considering physiological and socioeconomic adaptation: a modelling framework
Rai M, Breitner S, Wolf K, Peters A, Schneider A, Chen K. Future temperature-related mortality considering physiological and socioeconomic adaptation: a modelling framework. The Lancet Planetary Health 2022, 6: e784-e792. PMID: 36208641, DOI: 10.1016/s2542-5196(22)00195-4.Peer-Reviewed Original ResearchAssociations between long-term drought and diarrhea among children under five in low- and middle-income countries
Wang P, Asare E, Pitzer VE, Dubrow R, Chen K. Associations between long-term drought and diarrhea among children under five in low- and middle-income countries. Nature Communications 2022, 13: 3661. PMID: 35773263, PMCID: PMC9247069, DOI: 10.1038/s41467-022-31291-7.Peer-Reviewed Original Research
2021
Role of meteorological factors in the transmission of SARS-CoV-2 in the United States
Ma Y, Pei S, Shaman J, Dubrow R, Chen K. Role of meteorological factors in the transmission of SARS-CoV-2 in the United States. Nature Communications 2021, 12: 3602. PMID: 34127665, PMCID: PMC8203661, DOI: 10.1038/s41467-021-23866-7.Peer-Reviewed Original ResearchAssociation between extreme temperatures and emergency room visits related to mental disorders: A multi-region time-series study in New York, USA
Yoo EH, Eum Y, Roberts JE, Gao Q, Chen K. Association between extreme temperatures and emergency room visits related to mental disorders: A multi-region time-series study in New York, USA. The Science Of The Total Environment 2021, 792: 148246. PMID: 34144243, DOI: 10.1016/j.scitotenv.2021.148246.Peer-Reviewed Original ResearchConceptsEmergency room visitsER visitsMental disordersRoom visitsShort-term exposurePotential effect modificationMental health disordersSpecific mental disordersPositive associationRace/ethnicityEffect modificationExposure-response curvesStratified analysisLag non-linear modelHealth disordersTime-series studySubstance abuseRisk estimatesAnxiety disordersVisitsDisordersMental diseasesCertain populationsSignificant differencesTime trendsAmbient carbon monoxide and daily mortality: a global time-series study in 337 cities
Chen K, Breitner S, Wolf K, Stafoggia M, Sera F, Vicedo-Cabrera AM, Guo Y, Tong S, Lavigne E, Matus P, Valdés N, Kan H, Jaakkola JJK, Ryti NRI, Huber V, Scortichini M, Hashizume M, Honda Y, Nunes B, Madureira J, Holobâcă IH, Fratianni S, Kim H, Lee W, Tobias A, Íñiguez C, Forsberg B, Åström C, Ragettli MS, Guo YL, Chen BY, Li S, Milojevic A, Zanobetti A, Schwartz J, Bell ML, Gasparrini A, Schneider A. Ambient carbon monoxide and daily mortality: a global time-series study in 337 cities. The Lancet Planetary Health 2021, 5: e191-e199. PMID: 33838734, DOI: 10.1016/s2542-5196(21)00026-7.Peer-Reviewed Original ResearchConceptsExposure-response curvesAmbient carbon monoxideTotal mortalityDaily mortalityUK Medical Research CouncilElevated mortality riskLarge epidemiological investigationsPotential publication biasMedical Research CouncilCity-specific associationsMeta-analytical modelsShort-term associationsQuasi-Poisson distributionCurrent air quality guidelinesEpidemiological evidenceMortality riskDaily total mortalityShort-term exposurePublication biasSignificant associationEpidemiological investigationsTime-series studyGreater riskMortalityMortality data
2020
Air pollution reduction and mortality benefit during the COVID-19 outbreak in China
Chen K, Wang M, Huang C, Kinney PL, Anastas PT. Air pollution reduction and mortality benefit during the COVID-19 outbreak in China. The Lancet Planetary Health 2020, 4: e210-e212. PMID: 32411944, PMCID: PMC7220178, DOI: 10.1016/s2542-5196(20)30107-8.Peer-Reviewed Original ResearchHourly Exposure to Ultrafine Particle Metrics and the Onset of Myocardial Infarction in Augsburg, Germany
Chen K, Schneider A, Cyrys J, Wolf K, Meisinger C, Heier M, von Scheidt W, Kuch B, Pitz M, Peters A, Breitner S, Group F. Hourly Exposure to Ultrafine Particle Metrics and the Onset of Myocardial Infarction in Augsburg, Germany. Environmental Health Perspectives 2020, 128: 017003. PMID: 31939685, PMCID: PMC7015564, DOI: 10.1289/ehp5478.Peer-Reviewed Original ResearchConceptsMyocardial infarctionMI casesTime-stratified case-crossover analysisConditional logistic regressionInterquartile range increaseCase-crossover analysisTwo-pollutant modelsMI registryEpidemiological evidenceDifferent particle metricsCardiovascular diseaseMyocardial infractionSimilar associationLogistic regressionHourly air pollutionParticle metricsEffect estimatesHealth effectsExposure metricsIndependent effectsTransient exposureInfarctionAssociationExposureAerodynamic diameter
2019
Temporal variations in the triggering of myocardial infarction by air temperature in Augsburg, Germany, 1987–2014
Chen K, Breitner S, Wolf K, Hampel R, Meisinger C, Heier M, von Scheidt W, Kuch B, Peters A, Schneider A, Peters A, Schulz H, Schwettmann L, Leidl R, Heier M, Strauch K. Temporal variations in the triggering of myocardial infarction by air temperature in Augsburg, Germany, 1987–2014. European Heart Journal 2019, 40: 1600-1608. PMID: 30859207, DOI: 10.1093/eurheartj/ehz116.Peer-Reviewed Original ResearchConceptsMyocardial infarctionMI riskCases of MIRisk of MITime-stratified case-crossover analysisPopulation susceptibilityCase-crossover analysisArea of AugsburgCoronary deathDiabetes mellitusNon-significant declineSubgroup analysisRelative riskLag non-linear modelShort-term exposureMI eventsEnvironmental triggersInfarctionRiskFuture studiesSocioeconomic settingsAssociationExposureSusceptibility
2018
Future ozone-related acute excess mortality under climate and population change scenarios in China: A modeling study
Chen K, Fiore AM, Chen R, Jiang L, Jones B, Schneider A, Peters A, Bi J, Kan H, Kinney PL. Future ozone-related acute excess mortality under climate and population change scenarios in China: A modeling study. PLOS Medicine 2018, 15: e1002598. PMID: 29969446, PMCID: PMC6029756, DOI: 10.1371/journal.pmed.1002598.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge DistributionAge FactorsAgedAir PollutantsCardiovascular DiseasesCause of DeathChildChild, PreschoolChinaClimate ChangeEnvironmental MonitoringFemaleHealth StatusHumansInfantInfant, NewbornInhalation ExposureMaleMiddle AgedModels, TheoreticalOzonePopulation DynamicsPrognosisRespiratory Tract DiseasesRisk AssessmentRisk FactorsSeasonsTime FactorsUrban HealthVehicle EmissionsYoung AdultConceptsGlobal chemistry-climate modelChemistry-climate modelOzone-related mortalityRepresentative Concentration PathwaysEmission scenariosHigh global warmingGlobal warmingClimate changeChange scenariosOzone pollutionClimate Change (IPCC) Representative Concentration PathwaysEmission scenario RCP8.5Emission scenarios RCP4.5Future ozone projectionsStatistical downscaling approachModerate global warmingOzone precursor emissionsFine spatial resolutionSpatial resolutionHigh ambient ozoneOzone projectionsOzone changesOzone observationsScenario RCP8.5Change projections