2018
Skeletal disease in a father and daughter with a novel monoallelic WNT1 mutation
Ang K, Rangel E, Yuan Q, Wu D, Carpenter TO, Insogna K. Skeletal disease in a father and daughter with a novel monoallelic WNT1 mutation. Bone Reports 2018, 9: 154-158. PMID: 30364642, PMCID: PMC6197702, DOI: 10.1016/j.bonr.2018.09.001.Peer-Reviewed Original ResearchLow bone mineral densityLow bone massBone mineral densityWNT1 mutationsMineral densityMonoallelic mutationsBone massSame heterozygous missense mutationLow-impact fracturesExtra-skeletal manifestationsSevere osteogenesis imperfectaCanonical Wnt-β-catenin pathwayWnt-β-catenin pathwayType 1 collagen genesType 1 collagenHeterozygous missense mutationAdult skeletal homeostasisTraumatic fracturesSevere diseaseBiallelic diseaseIndex caseTherapeutic benefitRelated patientsSkeletal homeostasisSkeletal disease
2015
The effects of dietary protein and amino acids on skeletal metabolism
Bihuniak JD, Insogna KL. The effects of dietary protein and amino acids on skeletal metabolism. Molecular And Cellular Endocrinology 2015, 410: 78-86. PMID: 25843057, PMCID: PMC5852680, DOI: 10.1016/j.mce.2015.03.024.BooksConceptsDietary proteinDietary protein intakeOptimal skeletal growthRecent data bearingSkeletal healthCalcium economyMineral metabolismSkeletal metabolismProtein intakeDietary allowanceSkeletal homeostasisNutrient intakeSkeletal massIntakeSkeletal growthSite-specific effectsMolecular mechanismsMetabolismVariable levelsLife continuumProtein
2009
The Effect of Proton Pump-Inhibiting Drugs on Mineral Metabolism
Insogna KL. The Effect of Proton Pump-Inhibiting Drugs on Mineral Metabolism. The American Journal Of Gastroenterology 2009, 104: ajg200944. PMID: 19262542, DOI: 10.1038/ajg.2009.44.BooksConceptsProton pump inhibitorsMineral metabolismLong-term proton pump inhibitorsIntestinal calcium absorptionHip fracture ratesClass of drugsFragility fracturesBone lossCalcium economyPump inhibitorsCalcium absorptionFracture ratesCalcium balanceSkeletal homeostasisGreater riskAdverse effectsHigh rateDrugsRecent studiesMetabolismLong term