2017
Selective deletion of the soluble Colony-Stimulating Factor 1 isoform in vivo prevents estrogen-deficiency bone loss in mice
Yao GQ, Troiano N, Simpson CA, Insogna KL. Selective deletion of the soluble Colony-Stimulating Factor 1 isoform in vivo prevents estrogen-deficiency bone loss in mice. Bone Research 2017, 5: 17022. PMID: 29152381, PMCID: PMC5684603, DOI: 10.1038/boneres.2017.22.Peer-Reviewed Original ResearchBone mineral densityEstrogen-deficiency bone lossBone lossO miceTotal bone mineral densityWild-type female miceDual-energy X-ray absorptiometryX-ray absorptiometrySham-OVXReverse transcription-PCRFemale miceMineral densityWT controlsOVXSelective deletionMiceTranscription-PCRSignificant differencesCSF1Bone tissueMicro-CTSkeletal tissuesTissueNon-redundant functionsAnimals
2010
Osteoclasts Lacking Rac2 Have Defective Chemotaxis and Resorptive Activity
Itokowa T, Zhu ML, Troiano N, Bian J, Kawano T, Insogna K. Osteoclasts Lacking Rac2 Have Defective Chemotaxis and Resorptive Activity. Calcified Tissue International 2010, 88: 75-86. PMID: 21110188, PMCID: PMC3155765, DOI: 10.1007/s00223-010-9435-3.Peer-Reviewed Original ResearchConceptsTrabecular bone massBone massMature osteoclastsFemoral cortical thicknessTotal bone areaNumber of osteoclastsWild-type miceNormal tooth eruptionNumber of osteoblastsWild-type animalsBone resorptionCortical porosityActin ring formationCortical thicknessTooth eruptionOsteoclast functionResorptive activityDefective chemotaxisBone areaFemale animalsMiceOsteoclastsMigratory rateNormal sizeSignificant differences