2014
Cannabinoid receptor expression in femora and tibiae of C57/blk6 mice fed DHA and relationship to bone ash and BMC (1032.2)
Kim J, Insogna K, Watkins B. Cannabinoid receptor expression in femora and tibiae of C57/blk6 mice fed DHA and relationship to bone ash and BMC (1032.2). The FASEB Journal 2014, 28 DOI: 10.1096/fasebj.28.1_supplement.1032.2.Peer-Reviewed Original ResearchEndocannabinoid systemBody weightFed miceHigher BMCMice fed DHACannabinoid receptor expressionDiet fed miceMost peripheral tissuesDHA feedingReceptor expressionCB2 expressionPeripheral tissuesSkeletal metabolismCannabinoid receptorsTibia ash weightCurrent epidemicBone remodelingDay 118MiceControl lipidHigh expressionFemurTibia ashMouse femurAsh weight
2010
Targeted overexpression of Dkk1 in osteoblasts reduces bone mass but does not impair the anabolic response to intermittent PTH treatment in mice
Yao GQ, Wu JJ, Troiano N, Insogna K. Targeted overexpression of Dkk1 in osteoblasts reduces bone mass but does not impair the anabolic response to intermittent PTH treatment in mice. Journal Of Bone And Mineral Metabolism 2010, 29: 141-148. PMID: 20602130, PMCID: PMC3457021, DOI: 10.1007/s00774-010-0202-3.Peer-Reviewed Original ResearchConceptsParathyroid hormonePTH treatmentBone massTg miceAnabolic responseDKK1 expressionSingle daily subcutaneous doseDaily subcutaneous doseBone formationIntermittent PTH treatmentPotent anabolic agentOverexpression of DKK1Number of osteoblastsSubcutaneous doseWT miceReal-time PCRSkeletal sitesDickkopf-1Anabolic agentsBody weightTransgenic miceHistomorphometric parametersHistomorphometric analysisTargeted overexpressionPrimary murine osteoblasts
2004
The Effect of Aging on the Skeletal Response to Intermittent Treatment with Parathyroid Hormone
Knopp E, Troiano N, Bouxsein M, Sun BH, Lostritto K, Gundberg C, Dziura J, Insogna K. The Effect of Aging on the Skeletal Response to Intermittent Treatment with Parathyroid Hormone. Endocrinology 2004, 146: 1983-1990. PMID: 15618351, DOI: 10.1210/en.2004-0770.Peer-Reviewed Original ResearchConceptsBody bone mineral densitySkeletal responseAged animalsIntermittent treatmentTotal body bone mineral densityYoung adult C57BL/6 miceDaily sc injectionsVehicle-treated animalsTrabecular bone volume fractionYoung adult miceBone mineral densityYoung adult animalsVertebral histomorphometryEffect of ageBone volume fractionParathyroid hormoneC57BL/6 miceSC injectionPTH treatmentMineral densityBody weightOsteoblast numberPTHCultured marrowYounger counterparts
1996
Designing an Outpatient Research Diet to Enhance Dietary Compliance
Caseria D, Gay L, Liskov T, Marshall L, Insogna K, Kerstetter J. Designing an Outpatient Research Diet to Enhance Dietary Compliance. Journal Of The Academy Of Nutrition And Dietetics 1996, 96: a77. DOI: 10.1016/s0002-8223(96)00582-2.Peer-Reviewed Original ResearchDietary complianceCalcium metabolismDietary proteinResearch dietsExperimental dietsUnusual physical activityMedication useHealthy womenMetabolic kitchenOutpatient basisExperimental periodMenstrual periodStudy protocolUrinary nitrogen excretionCaloric intakeResearch dietitianPhysical activityBody weightLevels of proteinRandom orderFood requestsDietDaily log sheetsUrinary nitrogenDietitians